Tuesday, June 19, 2018
Hundreds of scientific studies have established that obesity often leads to severe health problems and cuts short many lives. Nevertheless, a significant number of obese people remain healthy despite their excess weight. A new IRP study has now identified a possible molecular marker that distinguishes obese but healthy individuals from those whose weight has negatively affected their health.
Thursday, June 14, 2018
Research into the collection of microorganisms that live in and on our bodies — known as the microbiome — has dramatically expanded in recent years. In fact, the field is one of 12 domains designated as top long-term IRP research priorities. Since the establishment of the NIH’s Human Microbiome Project in 2007, investment in microbiome research across the IRP has increased over forty-fold and now occurs in dozens of labs across more than 20 institutes and centers.
Wednesday, June 13, 2018
Access to robust computing resources provides a critical foundation for advancing the wide variety of biomedical research taking place within the NIH’s Intramural Research Program (IRP). Whether performing molecular modeling simulations, generating whole-genome sequencing data, deducing the structures of biomolecules, or advancing drug discovery efforts, our ability to analyze large-scale biological and biomedical data strongly depends on our ability to employ computationally intensive approaches that produce interpretable results and advance translational efforts aimed at improving human health.
Tuesday, June 5, 2018
The most important step to solving any problem is to choose the right tool for the job. Just like a heavy fur coat will keep you comfortable in the Arctic but slowly roast you in the Sahara, your immune system’s response can be helpful or harmful depending on the specific invader it’s fighting off. A new IRP study has identified a molecular “switch” that shifts an important type of immune cell between two different approaches to protecting the body.
Thursday, May 31, 2018
A fascinating statistic crossed my desk this month: Among U.S.-based institutions, the NIH has the highest representation of women scientists and engineers on filed international patent applications. I can believe it, and there’s a report documenting it from the World Intellectual Property Office (WIPO), a UN-affiliated organization.
Wednesday, May 23, 2018
Is the Yanny vs. Laurel debate tearing your office or lab apart? Well, according to NIH IRP investigators, there's no true answer to what this word is. As brain expert Mark Hallett, M.D., of the NIH National Institute of Neurological Disorders and Stroke puts it, "Perception is not reality, however real it seems."
Tuesday, May 22, 2018
It might seem easy to blame your parents for the way you turned out; after all, they raised you and gave you all of your DNA. But, before throwing blame around, consider saving some for the place where you grew up. According to new IRP research, being raised in an urban environment can dramatically alter how your genes influence your brain.1
Tuesday, May 8, 2018
Most people experience anxiety at some point in their lives, whether it’s pre-speech jitters or sweaty palms when their plane takes off. While mild feelings of nervousness are completely normal and can even be beneficial, anxiety can also have negative repercussions if it causes somebody to completely avoid situations like social encounters or taking a flight to visit distant family.
Monday, May 7, 2018
On Wednesday, May 2, hundreds of researchers gathered at NIH’s Natcher Conference Center to show off their recent discoveries. But unlike a typical scientific conference, the letters “M.D.” and “Ph.D.” were noticeably absent from these scientists’ credentials. Instead, the event — NIH’s annual Postbac Poster Day — celebrated the accomplishments of individuals participating in the NIH Postbaccalaureate Intramural Research Training Award (IRTA) Program.
Wednesday, April 25, 2018
Ever since the Human Genome Project (HGP) launched in 1990, patients and members of the public have been inundated with predictions about how unraveling the mysteries of genetics will revolutionize healthcare. Today, many of these promises remain unrealized, prompting some to become skeptical of the true utility of this research for improving human health. But, while more work is needed to fully realize the potential of genome-focused medicine, it remains true that patients are benefiting from our knowledge of the human genome in numerous, sometimes under-appreciated ways.