Tuesday, September 20, 2016
Given that Alzheimer’s is such a complex disease with many causes and pathways, it is not surprising that the search for effective treatments has proven difficult. So I spoke with Drs. Yujun Hou and Hyundong Song, postdoctoral fellows in the IRP’s Laboratory of Molecular Gerontology at the National Institute on Aging (NIA) to learn more about their approaches to meeting the challenge.
Thursday, September 8, 2016
By testing 6,000 FDA-approved drugs and experimental chemical compounds on Zika-infected human cells in the lab, a team that includes IRP scientists has shown that some existing drugs might be repurposed to fight Zika infection and prevent the virus from harming the developing brain.
Tuesday, August 9, 2016
Scientists use a variety of laboratory techniques to investigate the genetic cause of human diseases. While mice and rats have been common choices for modeling human diseases in the past, the use of zebrafish is rapidly gaining popularity. Does this surprise you? Let me explain.
Thursday, July 14, 2016
As a theoretician in the lab of Dr. Ralph Nossal (NICHD), I use mathematical modeling to study how cells get to places in the body. Most of my time is focused on completing clearly written goals born from project plans. A system of timers, project plans, and goals keeps me on track to do what I need to do so that I can get back to the fun part of my job that I would happily do for free.
Thursday, June 30, 2016
We all know that exercise is important for a strong and healthy body. Less appreciated is that exercise seems also to be important for a strong and healthy mind, boosting memory and learning, while possibly delaying age-related cognitive decline. How is this so? Researchers have assembled a growing body of evidence that suggests skeletal muscle cells secrete proteins and other factors into the blood during exercise that have a regenerative effect on the brain.
Tuesday, June 7, 2016
Last month we lost a remarkable investigator, Robert Nussenblatt, M.D., M.P.H., chief of the Laboratory of Immunology at the National Eye Institute (NEI). Bob was a world-renowned expert in uveitis, an inflammatory eye disease and a leading cause of blindness in younger people. He was instrumental in establishing the pathology of and treatment for uveitis. Bob was diagnosed with a metastatic cancer just a few months ago. He remained characteristically optimistic even as his prognosis rapidly grew worse. He died on April 17, 2016, at age 67 with his family by his side. The NIH staff just devastated to hear the news of his death, because so few knew Bob was ill.
Tuesday, May 17, 2016
You may already know that diet, obesity, exposure to the sun, radiation, and hormones are just a few of the many risk factors associated with cancer diagnoses. But, do you know about other risk factors, especially those playing out through epigenetics, the molecular relationship between the environment and our DNA? Read more...
Tuesday, May 3, 2016
Second in the Orloff Award recipient series are Drs. Jay Chung and Stewart Levine for their characterization of the role of DNA-dependent protein kinase (DNA-PK) in dendritic cell function in asthma and for the identification of the role of pharmacological inhibition of DNA-PK as a novel treatment approach for asthma.
Monday, May 2, 2016
It’s hard to imagine that just 26 years ago, getting email capability was a big achievement, because connectivity and computers go hand in hand. In 1990, the National Institutes of Health Utility Network (NUnet) connected all 36 NIH buildings on and off campus.
Thursday, April 28, 2016
Research suggests that two-thirds of U.S. adults drink two or more cups of coffee a day. There are multiple reasons for this, likely because coffee has multiple effects on the body. Consider the standard morning scenario for many people.