Tuesday, July 17, 2018
The constant combat between cancer and the body’s defenses can wear a tumor out. Unfortunately, cancer cells can pause their life cycle to repair themselves before re-entering the fray with renewed vigor. According to new IRP research, preventing cancer from taking a time-out can make it more susceptible to attack by the immune system.
Tuesday, July 10, 2018
The NIH community and cancer scientists around the world were saddened to learn that Alan Rabson, M.D., a prominent former IRP researcher and Deputy Director of the NIH’s National Cancer Institute (NCI), passed away on July 4 at the age of 92.
Dr. Rabson first joined the NIH in 1955 as a pathologic anatomy resident in the NIH Clinical Center, which had opened just two years before, and he began studying cancer-causing viruses in an NCI intramural laboratory a year later. Over the course of his ensuing six decades with NIH, Dr. Rabson accumulated a great many stories, a few of which we have shared in his own words, pulled from a 1997 “NCI Oral History Project” interview.
Tuesday, July 3, 2018
Everyone has a different pain threshold; a plate that’s too hot for one person to touch might be easily handled by someone else, for example. Now, IRP researchers have found the first evidence that a person’s sensation of a painful temperature more strongly influences the body’s automatic response to it than does the actual temperature.
Tuesday, June 19, 2018
Hundreds of scientific studies have established that obesity often leads to severe health problems and cuts short many lives. Nevertheless, a significant number of obese people remain healthy despite their excess weight. A new IRP study has now identified a possible molecular marker that distinguishes obese but healthy individuals from those whose weight has negatively affected their health.
Thursday, June 14, 2018
Research into the collection of microorganisms that live in and on our bodies — known as the microbiome — has dramatically expanded in recent years. In fact, the field is one of 12 domains designated as top long-term IRP research priorities. Since the establishment of the NIH’s Human Microbiome Project in 2007, investment in microbiome research across the IRP has increased over forty-fold and now occurs in dozens of labs across more than 20 institutes and centers.
Wednesday, June 13, 2018
Access to robust computing resources provides a critical foundation for advancing the wide variety of biomedical research taking place within the NIH’s Intramural Research Program (IRP). Whether performing molecular modeling simulations, generating whole-genome sequencing data, deducing the structures of biomolecules, or advancing drug discovery efforts, our ability to analyze large-scale biological and biomedical data strongly depends on our ability to employ computationally intensive approaches that produce interpretable results and advance translational efforts aimed at improving human health.
Thursday, June 7, 2018
Like many research institutions across the nation, the NIH has faced difficulties with establishing a strong and lasting community of diverse investigators. We have made remarkable gains in recent years, however, in attracting and retaining a diverse workforce that's more reflective of the U.S. population.
One of many movers and shakers in this realm is Hannah Valantine, a cardiologist recruited from Stanford University who, in addition to maintaining a lab in NHLBI, is the NIH's first Chief Officer for Scientific Workforce Diversity. And one of her many ideas that the NIH Scientific Directors hope to adopt is the creation of a cohort program with both mentors and mentees committed to issues of scientific diversity and inclusion. Our goal is to guide this cohort of tenure-track investigators through the tenure process to be sure they have access to the mentoring, professional development, and networking opportunities to establish their careers, strengthen their science, and, in turn, recruit and mentor future generations of scientists.
Tuesday, June 5, 2018
The most important step to solving any problem is to choose the right tool for the job. Just like a heavy fur coat will keep you comfortable in the Arctic but slowly roast you in the Sahara, your immune system’s response can be helpful or harmful depending on the specific invader it’s fighting off. A new IRP study has identified a molecular “switch” that shifts an important type of immune cell between two different approaches to protecting the body.
Monday, June 4, 2018
The NIH Lasker Clinical Research Scholar Program, an initiative to support early-stage clinical researchers, has reached a milestone. First announced in December 2010, the program provides scholars with up to ten years of support: five to seven years as NIH tenure-track investigators, followed by three years additional funding at an extramural research institution, pending review, if they choose to leave the NIH. Our goal was to recruit a few scholars each year and have a “steady state” of 15 to 20 scholars on campus. We indeed are now up to 15 scholars, which meets this goal.
Thursday, May 31, 2018
A fascinating statistic crossed my desk this month: Among U.S.-based institutions, the NIH has the highest representation of women scientists and engineers on filed international patent applications. I can believe it, and there’s a report documenting it from the World Intellectual Property Office (WIPO), a UN-affiliated organization.