IRP Research Demonstrates the Perks of Overlooked Immune System Molecules
Countless Hollywood romances rely on the trope that, every so often, it turns out the thing you’ve been searching for has been right in front of you all along. Thanks to new IRP research, a molecule long-studied for its role in directing immune cells’ movement around the body is being seen in a new light as a potentially important player in medicine’s life-or-death struggle against antibiotic-resistant infections.
Annual Competition Tests Researchers’ Communication Skills
Everyone recognizes that science can’t just stay in the lab — it can only do good if it finds applications out in the wider world, whether that’s in the form of new technologies, new medical treatments, or a change in public policy. However, the importance of getting scientists out of the lab to engage with the public has been emphasized much less until recently. One of NIH’s approaches to solving that problem is its annual Three-Minute Talks (TmT) competition, which encourages NIH postbaccalaureate fellows, graduate students, and postdoctoral fellows to figure out a way to succinctly explain their research to people who may know nothing at all about what they do.
Every physician spends years in school getting trained to provide healthcare to patients with a wide array of health conditions, but not all of them know much about how the tools they use and the treatments they offer make it from the lab to the clinic. For the past year, 42 medical students took time off from their studies to fill in that gap first-hand by working in IRP labs as part of NIH’s Medical Research Scholars Program. As their stints at NIH wind down, each of them will return to medical school with valuable scientific training that will surely enhance their ability to help patients in the future. Keep reading to see how the MRSP has given a leg up to three of these bright future doctors.
Study Points to Potential Way to Improve Physical Therapy Interventions for Movement Disorder
It’s easy to take everyday activities like walking and typing for granted, but for people with cerebral palsy, any movement can be a struggle. Intensive physical therapy, starting at a young age, has long helped those individuals move more easily. Now, recent IRP research could provide a way to track how those and other treatments affect communication within the brain during movement, providing a tool that could help researchers more quickly evaluate which treatments work and which don’t.
IRP Research Suggests Older Adults May Benefit From Severely Limiting Alcohol Consumption
It seems like every news report touting the health benefits of a daily glass of wine is soon followed by another that claims consuming any amount of alcohol harms health. While the jury is still out on this issue for younger individuals, a recent IRP study suggests that alcohol consumption may accelerate the typical age-related erosion of the cardiovascular system.
Many scientific studies have established the myriad ways that aging and alcohol independently diminish the capacity of the heart and blood vessels to effectively move blood — and the vital oxygen and nutrients it carries — around the body. However, the effects of those two forces in combination remains an outstanding question with potentially significant implications for health and public policy.
NIH AI Symposium Highlights IRP Efforts to Harness Artificial Intelligence
Artificial intelligence is permeating seemingly every aspect of society — it’s even the villain in the latest Mission Impossible movie. Biomedical research is no exception to this trend, as showcased at this year’s NIH AI Symposium. The day-long event on May 16 showcased the many ways IRP researchers are harnessing the ever-growing learning capabilities of computers to explore how our bodies work and improve our health.
In between fascinating lectures by IRP senior investigators and visiting scholars from Harvard Medical School and the Massachusetts Institute of Technology, a handful of IRP postbaccalaureate fellows, graduate students, and postdocs also gave short talks about how their labs are utilizing AI and machine learning in their research. Read on to learn about how four of these efforts could one day help speed up therapeutic development for cancer and rare diseases, reveal the relationship between brain activity and behavior, and identify patients with sickle cell disease who would benefit the most from high-risk, intensive treatments.
IRP’s Dr. Adam Sowalsky Looks to Tumors’ Origins to Predict Outcomes
"Skate to where the puck is going, not where it has been." — hockey great Wayne Gretzky
Imagine two men, both diagnosed with prostate cancer. For one, the disease will remain a quiet shadow, never seriously threatening his life. For the other, it will become an aggressive adversary, resisting treatments and altering his future. This June, as Men's Health Month brings such realities into focus, a critical question echoes in clinics and labs: how can we identify early on which cancer will turn dangerous, and how can we use that knowledge to change a patient's outcome for the better?
IRP senior investigator Adam G. Sowalsky, Ph.D., believes the answer lies not just in how cancer adapts during treatment, but in the evolutionary traits it already possesses when it first emerges.
Annual Event Provides Showcase for IRP Postbaccalaureate Fellows
As informative as undergraduate science courses can be, there’s no better way to learn the ins and outs of biology than to scrutinize and manipulate it in the lab every day. That’s why so many science enthusiasts flock to NIH after college to participate in the IRP Postbaccalaureate IRTA Program, which allows newly minted grads to spend a year or two working full-time in a lab at NIH. And rather than demonstrating the knowledge they’ve gained on a test, IRP postbacs get to present their research at NIH’s Postbac Poster Day each year, an environment akin to the poster sessions at scientific conferences many postbacs will be attending as they continue their scientific careers.
This year, more than 900 IRP postbacs showed off their research at the event, and unlike prior years, all their presentations were done during one absolutely jam-packed day rather than being spread over two days. Read on to learn about how five of them have taken advantage of the opportunity to work in IRP labs over the past year.
Brain Research Helps Understand and Treat Childhood Anxiety
It’s perfectly normal for young children to throw tantrums or be nervous on their first day of school, and for adolescents to be anxious about what their peers think of them. However, for some children and teens, negative emotions can escalate to unhealthy levels, resulting in significant distress and impairing their quality of life.
IRP senior investigator Daniel Pine, M.D., is on a mission to understand how that happens and figure out ways to help those kids. In honor of Mental Health Month, we talked with Dr. Pine about how his research is revolutionizing the field of pediatric psychiatry and paving the way for new, non-pharmaceutical treatments.
IRP Study Reveals Influence of Calorie Intake and Reproductive Cycle on Sleep
Doctors have long emphasized the importance of maintaining a healthy body weight and getting enough sleep, but in our time-limited lives, we often have to choose between spending time exercising, preparing healthy meals, and getting sufficient shuteye. And the number of hours in the day may not be the only thing that pits weight loss against sleep. A recent IRP study suggests that young women who are not obese get poorer sleep when they change their diets in order to lose weight.
This page was last updated on Friday, January 14, 2022
