IRP Investigator Bevil Conway Discusses the Science Behind the Headlines
Monday, July 15, 2019
What started as a friendly bet between investigators soon produced a major scientific discovery that calls into question the long-standing notion that non-human primates serve as accurate models for the way human brains function. The study, conducted by IRP investigator Bevil Conway, Ph.D., made headlines recently with reports in outlets such as NPR and U.S. News and World Report. We’re going Behind the Headlines with Dr. Conway to dive deeper into the story, understand the significance of his findings, and see where his work could lead.
IRP Study Suggests a Way to Prevent Unhealthy Fat Buildup
Tuesday, July 9, 2019
Many important scientific discoveries happen when a scientist stumbles across something curious and decides to investigate further. Alexander Fleming, for example, famously discovered penicillin by examining mold that grew in one of his petri dishes while he was away on vacation. A recent IRP study spurred by a similarly unexpected observation could eventually lead to a method of preventing or reversing unhealthy amounts of fat storage in the liver.
Monday, July 1, 2019
Summer has finally arrived, and it's once again time to shine some light on NIH's rich history. Over the past couple months, NIH has celebrated several important anniversaries, including the 20th birthday of NIH's Vaccine Research Center and the 70th anniversary of the NIH Record newsletter. Read on to learn more about these milestones and other fun facts and intriguing objects from NIH's past!
A Conversation with Dr. Paolo Lusso
Thursday, June 27, 2019
First discovered in 1981, human immunodeficiency virus, or HIV, caused one of the most deadly and persistent epidemics in history. HIV destroys CD4+ T cells, a type of white blood cell essential for fighting infection. In doing so, HIV destroys the body’s ability to fight off disease, which often leads to life-threatening consequences.
Today, medications have allowed people living with HIV to lead healthier lives. However, HIV still remains a major public health concern and continues to be studied by researchers within the IRP and beyond.
IRP research has produced findings essential to the development of current HIV treatments and tools for diagnosis. However, there is still a lot left to learn. One recent IRP contribution to HIV research was a 2017 study led by IRP senior investigator Paolo Lusso, M.D., Ph.D., which suggests that treatments targeting a protein called integrin α4β7 could potentially become an addition to current treatment options for those with HIV, or provide new measures to prevent infection.
Treatment Regimen Allows Genetically Mismatched Skin Grafts in Mice
Tuesday, June 25, 2019
Thousands of patients who need an organ transplant die each year before a donor can be found. A new IRP study has identified a safer way to prevent a transplant recipient’s body from attacking a genetically dissimilar donor organ, which could dramatically expand the pool of potential organ donors.
Thursday, June 20, 2019
Along with scientists around the country and the world, the IRP community is mourning the loss of former NIH Director James B. Wyngaarden, M.D, who passed away on June 14. Dr. Wyngaarden served as the 12th NIH Director from 1982 to 1989. During that time, he guided the NIH's instrumental role in responding to the HIV/AIDS epidemic and initiating the Human Genome Project. He also played a key role in the creation of the NIH Children's Inn.
A Conversation with Dr. Lori Beason-Held
Tuesday, June 18, 2019
Expert estimates suggest that more than 5.5 million Americans may have dementia caused by Alzheimer’s, a disease currently ranked as the sixth-leading cause of death in the United States. Because of the condition’s growing prevalence and profound consequences for patients, understanding Alzheimer’s disease and other forms of cognitive decline is an important goal within the Intramural Research Program.
One example of the IRP’s many contributions to the field of Alzheimer’s research is a 2013 study that detected brain changes in older adults who would go on to develop cognitive impairment years before their memory began to fail. This research, led by IRP staff scientist Lori Beason-Held, Ph.D., aimed to understand who might be susceptible to developing Alzheimer’s disease and what factors contribute to the development of the disease before symptoms appear.
Disrupting Itch-Related Process Could Relieve Relentless Itching
Tuesday, June 11, 2019
For most people, the arrival of spring time means more time spent outdoors — and greater exposure to nuisances like biting insects and poison ivy that make us itch. New IRP research has revealed a detailed picture of how a particular type of cell causes itching, findings that may ultimately help researchers develop treatments for disorders that cause severe and long-lasting itch.
New Insights Could Help Reduce Premature Births
Tuesday, May 28, 2019
Any baby born less than 37 weeks after conception is considered premature, but not all premature births have the same root cause. In a new study, IRP researchers have detailed how a particular component of the immune system can trigger premature labor, which could help doctors prevent more preterm births.
Wednesday, May 15, 2019
The IRP has been home to a number of truly remarkable scientists who spent decades making discoveries and developing technologies that would go on to improve the lives of many. One of these giants was Theodor Kolobow, M.D., who passed away in March of last year at age 87. During his many years at the NIH's National Heart, Lung, and Blood Institute (NHLBI), Dr. Kolobow made momentous contributions to the study of our lungs and cardiovascular systems, including advancements in the development of artificial organs and key insights into the biological processes behind acute lung injury.
Dr. Kolobow's legacy lives on not only through his colleagues' fond memories and his lasting influence on medical practice, but also through the NIH's historical archives. Read on for a tour through Dr. Kolobow's life and career, as can only be told by the Office of NIH History.