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I am Intramural Blog

I am Intramural Blog

NHGRI Director Eric Green Elected to National Academy of Medicine

Sequencing the Human Genome Sparks Transformation in Medicine

Wednesday, February 7, 2024

Dr. Eric Green next to a drawing of a DNA molecule

Few people can say they got in on the ground floor of a foundational achievement in science, but that’s where Eric Green, M.D., Ph.D., Director of NIH’s National Human Genome Research Institute (NHGRI), found himself when he began his career. It’s no wonder, then, that he was elected to the prestigious National Academy of Medicine (NAM) in October 2023.

Thirty four years ago, as a newly minted physician-scientist, Dr. Green joined the Human Genome Project, an initiative that had among its leaders former NIH Director Francis Collins, M.D., Ph.D. The initiative aimed to determine the order of the roughly 3 billion DNA building blocks, called nucleotides, that constitute the genetic blueprint for building and operating our bodies. Today, Dr. Green leads the NIH Institute that was established to lead NIH’s contribution to that ambitious endeavor, overseeing the investigation and application of information and technologies that drive the application of genomics to modern-day medicine.

Brain Pathway Amplifies Pain After Injury

Mouse Study Could Aid Development of Treatments for Chronic Pain

Tuesday, January 30, 2024

patient with shoulder injury talks with doctor

Getting hurt or sick is bad enough, but millions of patients around the world continue to experience pain or hypersensitivity even after their ailment resolves itself. Despite the prevalence of chronic pain, few effective treatments are available, especially ones without the potential for addiction that opioid medications carry. However, new IRP research has shown that suppressing the electrical firing of neurons in a certain brain area can alleviate injury-induced hypersensitivity in mice, providing a promising new target for treatments aimed at relieving chronic pain.

Delivering on Maternal Health

IRP’s Katherine Grantz Develops Tools to Predict Pregnancy Complications

Tuesday, January 23, 2024

pregnant woman in hospital

Advancements in medicine have reduced the risk of childbearing dramatically, but rates of maternal death have been creeping up in recent years. The reasons are varied. Older first-time parents, greater health concerns like obesity and hypertension, and lack of access to maternity care are important factors.

In observance of Maternal Health Awareness Day on January 23, we spoke with Katherine Grantz, M.D., a maternal-fetal medicine specialist and senior investigator at the Eunice Kennedy Shriver National Institute on Child Health and Human Development (NICHD). She is trying to improve health for pregnant people and their babies experiencing complications like gestational diabetes and hypertension, as well as reduce preterm deliveries and unnecessary C-sections.

IRP’s Michael Chiang Elected to National Academy of Medicine

NEI Director is Envisioning the Future of Eye Research

Wednesday, January 17, 2024

Dr. Michael Chiang

Vision is one of the most important ways we experience the world around us, so naturally, when disease and injury threaten sight, the impact of that loss can cause significant harm to our quality of life. That’s why, when Michael F. Chiang, M.D., became director of NIH’s National Eye Institute (NEI), he felt it was so important to incorporate this sentiment into his Institute’s new mission statement: “To eliminate vision loss and improve quality of life through vision research.”

This past fall, Dr. Chiang was elected to the National Academy of Medicine (NAM) for his own contributions to that mission, through his research on eye disease and the use of data and technology to improve treatment and access to vision care. His work has particularly focused on the diagnosis and treatment of retinopathy of prematurity (ROP), a complication that can lead to blindness among premature and low-birthweight babies.

Synthetic Materials Influence Body’s Healing Response

Research Could Lead to New Strategies for Treating Injuries

Tuesday, January 9, 2024

doctor examining knee after surgery

Modern medical advances mean that many people are not “only flesh and blood.” Mechanical devices and substances created in medical labs are commonly replacing or being added to parts of people’s bodies. A new IRP study has shed light on how some of those materials might influence the body’s healing process, providing insights that could eventually spur the creation of new ones that influence the behavior of the body’s immune system and allow doctors to better direct how the body repairs itself.

A History of NIH in 12 Objects

Lecture Explains Trinkets’ Links to Important Milestones

Monday, January 8, 2024

watch fob

The history of NIH and its precursor institution, the Hygienic Laboratory, stretches back nearly 140 years — way longer than any human being has ever lived. Even when those who have witnessed history are still around, the fading of memories threatens to erase our knowledge of the past. Fortunately, with proper storage and care, objects like those in the collections of the Office of NIH History and Stetten Museum can last hundreds of years, providing enduring reminders of important historical milestones.

On December 11, Stetten Museum curator Michele Lyons used a dozen such objects to describe the evolution of NIH from its origins to the modern day. Her presentation touched on topics ranging from NIH’s founding in New York to its key role in creating national standards for heart valve replacement surgery to the American AIDS crisis of the 1980s and 1990s.

HHS Awards Recognize IRP Cancer Researchers

Long Careers at NIH Yield Groundbreaking Achievements

Wednesday, January 3, 2024

from left to right: Dr. Robert Yarchoan, Dr. Elaine Jaffe, and Dr. Louis Staudt

When you work at the National Institutes of Health, major advances in health and science can seem like a regular occurrence. Yet not all advances are created equal; some change entire paradigms for understanding and treating disease, even disarming a disease’s lethal effects.

This fall, three IRP senior investigators received Departmental Awards from the United States Department of Health and Human Services (HHS) for their exceptional contributions to science: Louis M. Staudt, M.D., Ph.D., Elaine S. Jaffe, M.D., and Robert Yarchoan, M.D. Dr. Staudt received the HHS Secretary’s Award for Distinguished Service for his revolutionary work on the diagnosis and treatment of diffuse large B-cell lymphoma (DLBCL); Dr. Jaffe received the Secretary’s Award for Meritorious Service for her pioneering discoveries about lymphomas and blood cancers; and Dr. Yarchoan received the HHS Career Achievement Award for his role in developing the first effective drugs for AIDS and developing treatments for HIV-associated cancers.

Gene Therapy Protects Neurons From Alzheimer’s Disease

New Approach Preserves Cognitive Abilities in Pre-Symptomatic Mice

Tuesday, December 12, 2023

diagram showing a virus entering a cell and delivering a gene into its nucleus

Cooks preparing traditional holiday feasts will surely find that a fire extinguisher can effectively quench an oven inferno, but it would probably be better if the oven never caught fire in the first place. Similarly, Alzheimer’s researchers have focused much more on putting out the biological fires scorching patients’ brains than on making brain cells ‘fireproof.’ A new IRP study in mice, however, suggests better results might be achieved with an approach specifically designed to make patients’ neurons more resilient.

Taming Inflammation in the Intestines

IRP’s Warren Strober Breaks Down the Causes of Inflammatory Bowel Disease

Monday, December 4, 2023

man with stomach pains

For many, the holiday season brings expectations of delicious meals and treats with family and friends, but the nearly 1.6 million Americans who have inflammatory bowel disease (IBD) may need to skip these delights or endure serious digestive distress. It’s fitting, then, that the first week of December is Crohn’s and Colitis Awareness Week, an occasion that calls attention to the two conditions lumped together under the umbrella of IBD.

Of course, no awareness week is needed to remind IRP senior investigator Warren Strober, M.D., of the importance of learning more about those two conditions. An expert in how the immune system operates within the digestive system, Dr. Strober has spent decades looking for ways to provide relief for IBD sufferers.

NIH Mourns the Passing of S. Perwez Hussain

Friday, December 1, 2023

Dr. S. Perwez Hussain

The IRP community is profoundly saddened by the passing of S. Perwez Hussain, Ph.D., Senior Investigator in the Laboratory of Human Carcinogenesis at the National Cancer Institute (NCI). He died on November 24, 2023, after living with stage 4 colon cancer for many years.

For over 25 years, Perwez led translational research that could be brought into clinical trials for patients with pancreatic cancer and he established the pancreatic cancer research program in the Laboratory of Human Carcinogenesis. He was known as an exceptional scientist, caring mentor, kind colleague and friend to many.

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This page was last updated on Friday, January 14, 2022

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