Accomplishments by Date2024Open SESAME: Heart surgery without the surgery2023A new drug to treat Duchenne muscular dystrophy with fewer side effectsA single-shot Marburg vaccine shows promiseCreating a cell death suppressor to treat a wide range of diseasesExploring the structure and function of an epilepsy-related ion channelGenetic mutation associated with a form of muscular dystrophy can also block nose developmentHunting for disease-causing genetic variants in non-coding DNALow-cost test provides rapid diagnosis for diarrhea-causing infectionsLow-dose monoclonal antibody injections prevent malaria infectionNew technology provides hope for HIV cure strategiesNovel immunotherapy approach treats rare cancer-causing conditionProtecting damaged tissues with immunomodulatory biomaterialsUnderstanding how endocannabinoids in the brain help extinguish fear20223D organ model shows cadmium exposure in pregnancy may affect heart developmentA personalized clinical decision tool for women at high-risk of breast cancerA robotic exoskeleton helps kids learn to walk better outside the clinical settingArthritis medications may lower risk for Alzheimer’s disease in certain patientsArtificial intelligence improves diagnosis and risk prediction for vision-destroying diseaseBlocking stomach-derived hormone could yield new treatment for opioid use disorderCreating a less expensive and more accessible whole-body MRI scannerFDA-approved heart medication shows promise as treatment for alcohol use disorderFrequent use of chemical hair straighteners and relaxers is associated with uterine cancerOptimized production process leads to new FDA-approved treatment for fungal infectionsTargeted therapy improves survival for younger lymphoma patientsThwarting the flu with nanoparticle-based universal influenza vaccinesTwo distinct mechanisms drive severe alcoholic liver disease2021A new treatment for kidney cancers related to von Hippel-Lindau diseaseA new view of immune responses to fungal diseasesActivating brain cells that alleviate painAssessing topical treatments for eczema in 3D-biofabricated skin tissueBile acids in the brain provide a potential treatment target for Alzheimer’s diseaseBiological activity-based modeling identifies potential COVID-19 treatmentsBoosting immune cells to fight pneumonia without antibioticsBrain connection patterns may predict relapse in opioid use disorderCombining CT scans with artificial intelligence to assess cardiovascular health Defining a spine-to-brain pathway that drives painDiabetes drug may lower risk of certain types of breast cancerDiscovery of a rapid immune response to a dangerous skin infectionExploring how fasting blunts inflammationGenetically engineering immune cells to stop cancer from spreadingHow the cell’s DNA replication machinery overcomes obstacles Identification of a new genetic disorder affecting the brain and skullIdentifying RNA changes in skeletal muscle related to healthy agingInfections train the microbiome to defend against future threatsIntegrated robotic platform for scalable manufacturing and development of stem cellsModeling the interplay between processes that induce cancer-causing mutationsNew insights into the molecules and neurons responsible for the sense of touchRevealing new genetic variants associated with Lewy body dementiaSearching for signs of COVID-19 infection in the brainUncovering new aspects of a cellular danger system involved in inflammatory diseasesUncovering the cellular causes of anxiety due to social stressUsing monoclonal antibodies to prevent malaria2020A different delivery route may improve tuberculosis vaccine effectivenessA less toxic frontline therapy for adults with Burkitt lymphomaA new view of how muscles generate movementA Nobel win for the discovery of the hepatitis C virusA novel method for producing astatine-based cancer therapeuticsA targeted approach for treating Sjögren’s syndromeAge and ancestry affect production of induced pluripotent stems cellsAutoimmune antibodies cause life-threatening blood clots in COVID-19Bacteria help mammals build a key energy moleculeBlood test predicts liver cancer riskBrain’s sensory regions play a role in fentanyl relapseChanging fate by personalizing treatment for a high-risk blood cancerCommonly used antibiotic shows promise for combating Zika virusCoronavirus’ cellular exit strategy may aid its spread through the bodyDesigner drug for lowering triglyceridesDeveloping a crucial animal model for studying COVID-19Discovery of a new form of immunotherapy for the treatment of cancerFirst therapy approved for children with genetic tumor syndromeGenetic and immunologic underpinnings of some cases of severe COVID-19Highly selective compound could treat neuropsychiatric disorders with fewer side effectsHow a rare epilepsy-associated mutation disrupts neuronal communicationHow our internal clock tells us when it’s time for lunchHow the brain powers communication between neuronsHow the malaria parasite feeds inside a red blood cellHow you know when to go: identifying the mechanisms of bladder sensationIdentifying patterns of depression in new momsIdentifying reproducible sex-based differences in the human brainIdentifying the cellular basis of altered brain function in long-term cannabis usersKids’ exposure to secondhand smoke may lower school performanceNew insights into the cell’s cleaning systemRapid development of safe and effective COVID-19 vaccinesTaking the random out of biopsy samplingTreating a rare HIV-associated cancer without chemotherapyUsing artificial intelligence to better predict heart attacks, strokes, and deathZebrafish studies reveal molecular and cellular determinants of motor asymmetry2019A new treatment for a rare blood disorderA simple way to screen for cervical cancer with a smartphoneAssessing vital therapies for Ebola in the midst of an outbreakCellular diversity helps liver cancer shrug off immunotherapyCoordinated ‘ripples’ of brain activity signal successful memory retrievalDevelopmental consequences of prenatal and early life exposure to air pollutionDiscovering a link between genetics and high blood pressure in African AmericansDiscovering the surprising effects of the brain’s stress chemicalDrugs for DIPG: a guide for new therapies in a rare, lethal pediatric brain cancerFor older adults, every step countsHigh sugar intake worsens autoimmune disease in miceHighly potent binding molecules improve imaging and activation of lab-designed neuronal receptorsHow periodic calorie restriction bolsters the immune systemNeuron-specific genome modification in the adult rat brain using CRISPR-Cas9New insights into the role of mitochondria in autoimmune diseasesOrganisms that live on your skin help heal your woundsPotential new treatment paradigm for WHIM patients with refractory diseaseRevealing the structure of a sugar-transferring enzyme associated with colorectal cancerSticky protein boosts neuronal receptor’s response to anti-anxiety drugsStress hormones regulate stomach inflammationTurning off bedroom light sources could help stave off weight gainUnderstanding the ups and downs of pain modulationUnraveling the construction of cellular protein factoriesVisualizing the structure and coordination of the DNA replication machineryWearable technology revolutionizes symptom monitoring and treatment for bipolar disorderWild microbes make lab mice more accurate models for human immune studies2018A brainstem-spinal circuit controlling movement in response to painA novel mRNA modification may impact the human genetic codeA novel treatment for opioid use disordersA sneak peek into the social brain: miniScope imaging reveals neural coding of social behaviorBugs or bacon? How diet and the microbiome influence colorectal cancer riskChanges in blood proteins indicate aging trajectoriesControl of secretory granule maturation by the pgant9 geneControlling liver cancer via the gut microbiomeGestational diabetes provides a warning sign for increased risk of chronic diseases later in lifeHow enzymes in the cell membrane add grease to other cellular proteinsHow paying attention helps improve our memoryImmune cells linked to new model of gum diseaseIron exporter mutations provide malaria protection but predispose African Americans to iron overload diseaseIs cigarette choice genetic? Examining connections between race and a preference for mentholMechanism of age-associated failure of the heart’s pacemakerMetarrestin: a new approach to targeting the leading cause of cancer mortalityMitochondria in age-related disease: the importance of heteroplasmyNew therapy provides faster treatment for heart attacksNicotinamide riboside (NAD+) prevents DNA damage and shows cognitive benefits in preclinical model of Alzheimer’s diseaseOrganization of bigger brains shows how thinking drives brain developmentPair of proteins repairs cellular highway systemPoint-of-care diagnostics: a blood biomarker to diagnose mild traumatic brain injuriesPromising new treatment for fatal neurological disease Niemann-Pick type C1Rewarding social interaction prevents drug addiction in ratsSalt intake and sodium pump inhibitor linked to aortic stiffening and cardiovascular diseasesSomatostatin: a key factor in the transmission of itch and painTracing pathways in the brain to understand how light affects mood and learningTrust your gut: probiotics could directly block staphylococcus infectionUnderstanding key components of the brain’s stress circuitry2017A good sugar for treating diabetesAlpha-4 beta-7 integrin in HIV pathogenesisAntibodies to infections can cause neurological disordersAortic valve replacement in patients with inadequate arterial accessBattle of the sexes: when the female embryo takes controlBiomarker in blood may predict recovery time after sports concussionChemogenetics revealed: converted clozapine activates lab-designed neuronal receptorsDelaying pregnancy: can we test how fast the biological clock is ticking?Discovering how cells repair lethal DNA-protein crosslinksDiscovering X-linked acrogigantism: a new infant-onset overgrowth syndromeDoubling the power of light-sheet microscopyEffects of tobacco discount coupons and policy intervention on tobacco use disparitiesFostering the first FDA-approved drug for Merkel cell carcinomaFOUND: essential genes for cancer immunotherapyHow cells combat prions and amyloidsHow membrane fusion and fission occur in live cellsHow tumors invade and destroy tissuesImmune cells mediate the repair of blood vessels following traumatic brain injuryLinking genetic mutations to two rare facial conditionsLinking psoriasis inflammation and treatment with risk for cardiovascular diseaseMapping platinum in the inner ear after chemotherapyMitochondria power neuronal axon growth and regenerationNew biomarkers associated with lingering cancer treatment fatigue symptomsNew forms of CRISPR with applications in biotechnologyNew treatment for leukocyte adhesion deficiency type 1 (LAD1)Noninvasive imaging technique tracks brain activity with pinpoint precisionPain-free skin patch responds to blood sugar levels to manage type 2 diabetesPotential compounds for prevention and treatment of prescription opioid abuseQuantitative control mechanisms ensure the fidelity of cell divisionRethinking how the brain removes wasteRole of the ‘hunger hormone’ ghrelin in alcohol dependenceSkill learning encoded via brain’s parallel processing in cortex and striatumThree-in-one antibody protects monkeys from HIV-like virusWearable robotic exoskeleton improves walking posture in children with cerebral palsy2016A method of unraveling neural encoding mechanismsA novel treatment for cocaine use disordersAmygdala is as important as the ventral striatum for reinforcement learningBetter techniques for untangling correlations in big fMRI dataDiscovery of a new protein triaging pathway for neurotoxic proteinsDual antibody treatment suppresses HIV-like virusEngineering immunity to tumor elementsEnhanced risk-based lung cancer screening may prevent more deathsExtending the genetic code: identifying new DNA basesFolic acid levels impact the newborn epigenome and childhood asthma riskGene therapy to restore the architecture of the inner earHigh prevalence of electronic cigarette use among rural youth with asthmaHormones boost gene activity through super enhancersIdentifying novel monoclonal antibodies against Ebola virusImproving detection and prevention of undiagnosed diabetes in African-descent populationsIncreased physical activity is associated with lower risk of 13 types of cancerInsights into influenza through human challengeKetamine for the treatment of depression and other anxiety-related disordersLow-intensity smokers are at increased risk of earlier deathRepurposed drugs to the rescue: treating ZikaStimulating interferon genes to interfere with cancerThe many faces of the autophagy machinery: LAP as a critical regulator of inflammationTreating fatigue: a novel and promising path forward2015Creating a blood test to predict recurrence of a common lymphomaDesigning a new method for live albumin labeling and lymphatic imagingDissecting the immune responseDonor telomere length affects survival after hematopoietic cell transplantation for severe aplastic anemiaExploring the role of dopamine in cocaine abuseFinding molecular signatures of Alzheimer’s disease in blood extracellular vesiclesGaucher and Parkinson’s: Identifying one target for two diseasesHarnessing the immune system to fight epithelial cancersInterleukin-22 therapy: Providing new hope for alcoholic hepatitisRepurposing existing drugs and discovering new antivirals for hepatitis CSharper images of molecules using cryo-electron microscopyTraumatic brain injury: Linking a key protein to long-term complicationsTreating cocaine addiction with transcranial magnetic stimulationWatching deep-brain movement circuits in action2014Approaching a treatment for marijuana addictionCreating an artificial RNA receptor to deliver siRNA to TumorsDiscovering how amphetamine works in the brainExtreme obesity may shorten life expectancy by up to 14 yearsFinding new pathways in accelerated aging disordersGuarding against hearing loss from anti-cancer drugsHPV test better predicts cervical cancer risk than Pap testIdentifying a key neurological regulator of social memory and aggressionIdentifying genetic risk for type 2 diabetes and obesityIdentifying humans’ oldest animal relatives provides insights into the genetics of evolutionLearning about human skin’s microbiotaLearning that cells can use their nuclei like pistons to moveLinking genetics to recurrent strokes in children with DADA2Mapping irritable bowel syndromeNLM Scrubber: Paving the road to “Big Data” by securing patient privacyProgrammed cell death drives generation of immune system’s regulatory T cellsRepurposing drugs to fight EbolaRevealing drug-resistant malaria’s genetic and molecular fingerprintSafer and faster prion disease detectionSimple new tool makes treatment for neglected tropical diseases saferStudying childhood stroke to better understand inflammatory diseasesTesting a potential vaccine for the Chikungunya virusThey might be giants: Understanding a childhood genetic defectTime between morning wake-up and smoking a cigarette associated with rate of lung cancer riskUnderstanding sensory symptoms in autism: seeing the trees, but not the forest2013Alzheimer’s disease: challenging the amyloid dogmaCan fewer doses of HPV vaccine provide immunity?Candidate vaccine against RSV, a common childhood infectionDetecting brain changes years before Alzheimer’s disease onsetDeveloping a vaccine for all four dengue virusesDigging deeper into the basic principles of gene regulationDiscovering a new hepatitis C gene—and its implications for precision medicineExploring racial differences in antidepressant responseFinding the key to dendritic spine developmentIdentifying an Alzheimer’s disease risk geneInvestigational malaria vaccine found to be safe and protectiveItching for an answerLinking a genetic variant to alcoholismMapping the adult mouse brain using embryonic gene expressionMind-body practices and yoga may protect against neurodegenerative effects of chronic painNew views of emotional regulation and decision makingPower in numbers: identifying new genes associated with ankylosing spondylitisProtecting salivary glands from irradiation damageSeeing the shape of hepatitis B’s actionStimulating brain cells prevents compulsive cocaine seekingTackling the mysteries of osteosarcoma in children by uncovering gene variants associated with riskThe calculus of calories: mathematical models to quantify obesity and its treatmentVisualizing chromosomal translocations in living cellsVisualizing DNA repair in action2012A new approach to treating organ damage in inflammatory diseasesA non-addictive form of cocaine? A potential therapy awaitsCan we outwit the influenza virus with a universal vaccine?Chronic drinking may alter the brain and increase PTSD riskDisaster response tools that find missing people and save livesDiscovering monogenic forms of common variable immunogenicityDNA and damage control: A complex web of playersExposing “silent” heart attacks through novel imaging techniquesFission and fusion to help keep our cells healthyIdentifying a promising HIV vaccine targetLinking heavy exposure to diesel exhaust to lung cancer deaths in minersMedical radiation and cancer: minimizing the risk from CT scansOnly skin deep? New insights on retinoic acid in skin developmentOpen your eyes to the power of image-based online searchingPeripheral CB1 cannabinoid receptors as therapeutic targets in obesity and diabetesSpur of the moment purchase? Blame your orbitofrontal cortexTaking a closer look at our on/off relationship with insulinUnderstanding deafness: the role of auditory nerve mappingUnderstanding genetic recombination in a multi-cellular organismUsing genetics to understand stutteringVisualizing a viral infection as it happensVisualizing coronary artery disease2011Advancing rapid detection of prion diseasesPioneering closed-chest hole-in-the-heart repairReclassification of diseases improves understanding and outcomesStimulating new ideas on caffeine action in the brainTeam science unravels the link between ALS and FTDTracking the devastating effects of diethylstilbestrol (DES), a trans-placental carcinogenUnderstanding bacterial immune systemsUnraveling a complex world of neuronal connections2010Creating a new method to measure abdominal painDeciphering how chromosomal mix-ups lead to tumorsFinding independent roles for different cellular ESCRTsFoundation for CAR T-cell therapy YescartaIlluminating a path toward HIV vaccine developmentStopping Dengue in its tracksThe need for speed: A new approach to treating depressive disordersThe Teaching Tool: A digital cervix for colposcopistsUnderstanding health disparities in kidney disease2009How voltage ion channels interact with their surroundings2008Could you become addicted to something? Your genes reveal allDiseases with no diagnosis: Providing relief for the rare and unknownYeast proteins teach us about Alzheimer’s disease2006Inventing sharper and faster optical microscopes for live cell imaging2004Developing a better way to monitor the size of slow growing, complex tumors2002Using adoptive cell transfer to treat advanced cancer2001Identifying and understanding rare immune system diseasesMoving toward understanding polyglutamine toxicityThe HPV vaccine: Two decades of research pays offThere’s no “magic bullet” for cancer. Or is there?2000Developing efficient modification of genomic DNA through recombineeringDiscovering new tuberculosis drugsFinding one disease is actually many: Diffuse large B-cell lymphomasFrom hormone to pharmaceutical: lipodystrophy1999Understanding the breathing rhythm: respiratory pacemaker neurons located in the brain1998Understanding and sensing DNA damage1997Breaking down complex autoinflammatory diseases, and building up new hope1996Dissecting good from bad with laser-capture1995In the fight against viral hepatitis A, vaccines save livesLifting the lid on kidney cancer: Exposing the underlying genetics1994First successful treatment of childhood schizophreniaIL-15: Taking an immunotherapy from bench to bedside1991Advancing early, rapid diagnosis of river blindnessTherapy for inherited enzyme deficiencies1989Discovering a growth factor and its incredible healing powersProtecting at-risk children from a severe respiratory disease1985First detection and screening of the HIV virusFirst electronic medical record to support clinical researchFirst successful treatment of childhood OCDHitting HIV hard with HAART therapy1984Demonstration that HTLV-III is the causative agent of AIDS1982Anatomy of Perception: Identifying Two Visual Streams in the Brain1981Discovery of the disease agent causing Lyme disease1980Discovery of the first human retroviruses1976Discovery of interleukin-2 (IL-2)1974Developing the first rotavirus vaccine1970A sense of calm in bipolar disorder: The clinical trials of lithiumThe first understanding of how brain cells communicate1957Fluoridation: A public health milestone to make us all smile1951Understanding and Treating Fungal Infections View All Health Topics This page was last updated on Friday, January 14, 2022
