Treating cocaine addiction with transcranial magnetic stimulation

2015

Challenge

Cocaine use disorders afflict an estimated one million Americans, resulting in approximately 5,000 deaths from cocaine overdose each year external link icon. There is currently no treatment approved to address the neurobiology of this devastating disease.

Advance

IRP researchers led by Antonello Bonci, M.D., examined the neurobiological underpinnings of cocaine consumption in rodents using a technology called optogenetics, which allows researchers to control neurons using light. Optogenetically stimulating frontal regions of the brain in rodents reduced cocaine consumption and relapse rate. Further, a pilot study in patients with cocaine use disorders showed that modulating activity in a region of the brain called the dorsolateral prefrontal cortex in humans using transcranial magnetic stimulation (TMS) had similarly beneficial effects.

Impact

These findings provide evidence that doctors could use TMS to treat cocaine use disorders. The researchers have further assessed the promising approach in clinical trials and are now in the process of submitting their results to the FDA to begin the approval process for this novel treatment.

Publications

Chen BT, Yau H, Hatch C, Chou SL, Hopf FW, Bonci A. (2013). Rescuing Cocaine-induced Prefrontal Cortex Hypoactivity Prevents Compulsive Cocaine Seeking. Nature. 496(7445), 359-62.

Terraneo A, Leggio L, Saladini M, Ermani M, Bonci A, Gallimberti L. (2016). Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: pilot study. European Neuropsychopharmacology. 26(1), 37-44.