Wednesday, November 29, 2017, 3:00 pm to 4:00 pm (reception to follow)
Masur Auditorium, NIH Clinical Center (Bldg 10)
This year's William Paul Lecture features Thomas A. Waldmann, M.D., NIH Distinguished Investigator at the NIH National Cancer Institute, who will present "The two faces of the IL-15- Janus Kinase-Stat system: implications for the immunotherapy of autoimmune diseases and cancer" next in the Wednesday Afternoon Lecture Series (WALS).
Dr. Waldmann defined the IL-2 receptor alpha and beta subunits using the daclizumab antibody he discovered, an antibody that is approved by the FDA. He co-discovered IL-15 and performed the first in-human clinical trial with this agent in patients with malignancy. Furthermore, Waldmann defined molecular abnormalities of the common gamma cytokine, Jak/Stat signaling pathway in HTLV-1 associated adult T-cell lymphoma and translated this discovery with a trial of a Jak inhibitor in patients with this disorder.