A non-addictive form of cocaine? A potential therapy awaits



Cocaine addiction is a chronic and relapsing disorder that affects millions worldwide The Lancet - Addiction, exerting a toll in lives lost, families torn, and communities destroyed. No medications are currently available to treat cocaine addiction.


IRP and international researchers led by Amy Hauck Newman, Ph.D., discovered that R-modafinil, like cocaine, inhibits dopamine uptake, but binds to the dopamine transporter in a unique fashion that may not result in the same addictive response as cocaine.


Molecular and preclinical pharmacological findings support translation of R-modafinil studies to clinical trials in the cocaine-abusing population as a potential treatment.


Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH. (2012). R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biol Psychiatry., 72(5), 405-13.

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This page was last updated on Thursday, June 29, 2023