Revealing new genetic variants associated with Lewy body dementia
Age-related neurodegenerative conditions place a growing and substantial socioeconomic burden on U.S. society. To develop treatments for them, it will be necessary to increase our understanding of the genetic determinants underlying these complex syndromes and identify potential targets for therapeutic interventions. Lewy body dementia (LBD), for example, is a common form of dementia in the aging population, but its causes are poorly understood. Current treatments address only the symptoms, rather than the ailment’s root cause, and they have limited effectiveness.
To extend modern gene discovery efforts to LBD and to generate a resource for the research community, IRP researchers led by Sonya W. Scholz, M.D., Ph.D., performed whole-genome sequencing in a large group of patients with LBD as well as neurologically healthy individuals for comparison. They identified novel locations in the genome associated with the development of this devastating disease and showed similarities between the genetic underpinnings of LBD and those of Parkinson’s disease and Alzheimer’s disease.
The high-quality sequencing data generated in this study constitute the largest sequencing effort in LBD to date and are designed to accelerate the pace of discovery in dementia research. To that end, the data that the study produced have been made into a resource accessible to the broader research community. The molecular insights from this effort provide an important foundation for addressing a common form of dementia within the U.S. population and pave the way for developing precision medicine approaches to treating it.
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This page was last updated on Thursday, June 8, 2023