IRP Mouse Study Shows Promise of Treatment Strategy
Earth’s jungles, deserts, and oceans are chock-full of wonderous creatures that have inspired a wide array of cutting-edge technologies, from strong yet flexible clothes made of synthetic spider silk to the plant-derived aspirin and morphine that have long been used as painkillers. Over the past few years, scientists at NIH and elsewhere have added sharks and camels to that list due to unique molecules their immune systems make. IRP researchers recently showed that one of those molecules could potentially be used to treat the devastating neurological disease known as multiple sclerosis.
Minimally Invasive Procedure Provides Help for Ailing Hearts
In the story of Ali Baba and the Forty Thieves, two magic words were necessary to open the cave where treasure was hidden. At NIH, researchers are applying those same special words, ‘open sesame,’ to unlock a chamber that is similarly difficult to access. In this case, however, it’s the left ventricle of the human heart.
“Enter one of the greatest acronyms in medicine: Open SESAME,” says IRP senior investigator Robert Lederman, M.D., who leads the IRP’s Laboratory of Cardiovascular Intervention. “That’s what we’re doing: opening up space in the heart.”
IRP’s Adriaan Bax Elected to Royal Society for Pioneering Nuclear Magnetic Resonance Methods
“My mortal body is indeed a universe of atoms, but I am just an atom in the universe myself,” physicist Richard Feynman once wrote in a poem. Within our own bodily universes, all those atoms tell a story about how our bodies work — and how they sometimes don’t.
IRP Distinguished Investigator Adriaan Bax, Ph.D., has pioneered ways to watch those atoms using nuclear magnetic resonance (NMR) methods. This year, he was elected a Fellow of the Royal Society in recognition of his research, which has contributed greatly to our knowledge of how the proteins and nucleic acids that keep our bodies running smoothly are structured, how they move, and how they interact, particularly in relation to diseases caused by their malformations and malfunctions. The Royal Society, which was founded in England in the 1660s, is a fellowship of many of the world’s most eminent scientists and is the oldest scientific academy in continuous existence.
IRP Study Points to Strategy to Speed Healing and Reduce Age-Related Atrophy
Whether due to exercise or injury, our muscles are constantly breaking down and regenerating. Just like construction workers need a hearty lunch to fuel their hammer swings and nails to hammer, our cells need both energy and specific materials to rebuild our bodies. New IRP research has produced important insights into how cells create the energy and building blocks needed to repair our muscles, pointing to potential avenues for helping people recover from muscular injuries or retain more muscle as they age.
IRP Study Is Examining the Long-Term Effects of Treatments for Children With Cancer
Not long after German physicist Wilhelm Röntgen identified X-rays in 1895, doctors began using them to treat cancer. They soon realized, however, that this new ‘radium’ therapy — the forebearer of modern-day radiation therapy — could also cause cancer. Today, we know that radiation therapy poses much greater risks to children than adults because their cells are dividing more rapidly than those of adults, making the cells more sensitive to radiation. Children also have more years of life ahead of them during which a cancer instigated by their treatment might develop.
Scientist Honored for Discoveries About DNA Replication
Our cells’ ability to create more of themselves is crucial for many aspects of health, but a cell without DNA can’t do all that much. For that reason, perhaps the most crucial step in cell division is the replication of DNA. IRP Distinguished Investigator Thomas Kunkel, Ph.D., has spent his career trying to understand DNA replication, what happens when the process goes wrong, and what influences the likelihood of mistakes. Earlier this year, he was elected to the National Academy of Sciences (NAS) in recognition of his extensive contributions to this field.
Summer Poster Days Showcase IRP Summer Intern Research
Every summer, NIH welcomes hundreds of enthusiastic young men and women to its campuses to work as summer interns, providing them with scientific training and mentorship from some of the world’s preeminent researchers. As always, the Summer Internship Program culminated this year with Summer Poster Days, held on August 1 and 2, a bustling event where summer interns showcase the results of their immersion into IRP research. Nearly 800 IRP summer interns participated in this year’s event, presenting research on cancer vaccines, new applications for virtual reality technology, experimental antifungal treatments, how the brain perceives pitch in sounds, and much more. Read on for a glimpse at some of this year’s summer interns and the work they braved a blazing Washington, D.C., summer to pursue.
IRP Scientist Has Found New Ways to Wield the Immune System Against Cancer
Over the past twenty or so years, we’ve seen a sea change in many cancer therapies resulting from advances in immunotherapy. Rather than trying to poison cancer cells with chemotherapy or rip apart their DNA with radiation, these treatments help our own bodies attack the disease. As a result, we’ve seen a remarkable reduction in cancer deaths from many types of tumors.
NIH Distinguished Investigator Giorgio Trinchieri, M.D., has long stood at the forefront of these discoveries. This year, he was elected to the National Academy of Sciences (NAS) for his achievements in identifying the mechanisms regulating the activity of certain classes of immune cells and how the environment around a tumor interacts with the immune system to suppress an immune response to the disease. This includes searching for ways to expand the benefits of immunotherapy to more patients.
IRP Study Points to Treatment Target for Fatal Neurological Disorder
Just like we throw out our busted toasters and other appliances, our cells must continuously dispose of malfunctioning equipment to keep themselves working optimally. In certain neurological diseases, though, neurons die because they can’t get rid of misbehaving molecules. New IRP research provides crucial insights into a key player in this process, suggesting that restoring the function of a particular gene or boosting the levels of the enzyme it produces could help patients with the devastating disease known as amyotrophic lateral sclerosis (ALS).
IRP’s June Kwon-Chung Elected to National Academy of Sciences for Advances in Mycology
Even as a little girl, NIH Distinguished Investigator June Kwon-Chung, Ph.D., knew she would be a scientist. Seven decades later, she has been elected to the National Academy of Sciences (NAS) for her groundbreaking research on fungal diseases.
“My dream has always been to become a research scientist in the field of biology,” Dr. Kwon-Chung says. “This goes way back to when I was barely out of the toddler stage.”
As a child growing up in Korea before it split into two separate countries, Dr. Kwon-Chung felt blessed to have parents and teachers who nurtured her interests early. Her participation in her junior high school’s “Biology Club” led her to focus on the study of bacteria as a student at the Ewha Womans University in Seoul, Korea, even though wartime disruptions made scientific study challenging. In 1961, she won a year-long Fulbright Smith-Mundt scholarship to study in the U.S. and chose to attend the University of Wisconsin, where she specialized in mycology, the study of fungi.
This page was last updated on Friday, January 14, 2022
