Experimental Approach Predicts Future Alzheimer’s Diagnoses
Tuesday, October 15, 2019
If you looked through my garbage, you would probably find a litany of apple cores (my favorite fruit) and a couple fundraising requests from my alma mater. Similarly, scientists can learn a lot about what is going on in cells by examining their trash. IRP researchers recently developed a blood test that may be able to predict Alzheimer’s disease years before the onset of symptoms by examining packages of waste products from neurons.
Reddit “Ask Me Anything” Commemorates Breast Cancer Awareness Month
Friday, October 11, 2019
Breast cancer touches the lives of millions of Americans every year. In 2019 alone, researchers expect more than 300,000 American women to be diagnosed with breast cancer, along with more than 2,600 men. Roughly one out of every eight American women will develop invasive breast cancer at some point in her lifetime, making it the second most commonly diagnosed cancer in American women.
On October 9, in recognition of National Breast Cancer Awareness Month, the NIH Intramural Research Program (IRP) partnered with the National Cancer Institute (NCI) to host a Reddit “Ask Me Anything” (AMA) with two prominent researchers in the NCI's Women's Malignancies Branch: Stanley Lipkowitz, M.D., Ph.D., and Alexandra Zimmer, M.D. Between Dr. Lipkowitz’s extensive knowledge of the cellular and molecular pathways involved in breast cancer and Dr. Zimmer’s expertise in the development of clinical trials for breast cancer treatments, the pair were able to offer intriguing insights on topics ranging from recent advances in breast cancer treatment to genetic and environmental factors that influence risk for the disease. Read on for some of the most interesting exchanges that took place, or check out the full AMA on Reddit.
Therapeutic Strategy Enhances Natural Blood Sugar Control
Tuesday, October 1, 2019
Just like Sonny needed Cher to achieve music super-stardom and Stephen Curry needed Kevin Durant to win back-to-back NBA championships, sometimes a cell or molecule in the human body needs a partner’s assistance to work optimally. IRP researchers recently showed that a synergy between a lab-designed drug and a molecule naturally produced in the body could make for a promising therapy for type 2 diabetes.
Annual Event Highlights Contributions of IRP Postdoctoral Fellows
Monday, September 16, 2019
At lunchtime last Wednesday, the NIH Clinical Center’s FAES Terrace echoed with the joyful sounds of scientists nourishing their bodies and their brains. While those stopping by the annual NIH Research Festival poster session could be forgiven for making a beeline straight for the food — including the submissions to this year’s Scientific Directors’ baking competition — once their plates were full, they took advantage of the opportunity to satiate their scientific curiosity as well by checking out the dozens of posters on display.
Examining DNA Methylation Could Facilitate Targeted Cancer Therapy
Tuesday, September 3, 2019
As an amateur home chef, I know from experience that the ingredients you use can dramatically alter the way a recipe turns out. Leave out oregano and your tomato sauce will be bland; add too much red pepper and your plate of pasta will scorch your tongue.
In this way, it turns out, cooking is a lot like the process by which your genes manufacture the proteins that keep your body running. Just like the same recipe can result in a delicious or disappointing meal depending on how you modify it, a certain gene can produce several varieties of a single protein that behave in different ways. In some cases, these alterations may lead to disease. New IRP research has revealed that a genetic regulatory process called DNA methylation can contribute to cancer by changing which forms of a protein a gene produces.1
Discovery Could Improve Therapy for Multiple Autoimmune Diseases
Tuesday, August 20, 2019
Hiding among YouTube’s vast collection of cooking demos and funny cat videos are clips of patients and their advocates designed to raise awareness of specific diseases. It was just such a video that led IRP Senior Investigator Peter Grayson, M.D., M.Sc., to begin studying an extremely rare illness called deficiency of adenosine deaminase 2, or DADA2 for short. The recently published findings of that research could help improve treatment not just for patients with DADA2 but also many more individuals with similar ailments.
Annual Event Shares Research by IRP’s Summer Interns
Tuesday, August 13, 2019
NIH’s Natcher Conference Center was packed once again last Thursday for the annual Summer Poster Day. This year, more than 1,200 college and high school students spent their summer performing research in an IRP lab through the NIH’s Summer Internship Program.
I navigated through the more than 900 posters presented this year to get a taste of the impressive work done by these young men and women in less than three months. If they can make these kinds of discoveries in just one summer, imagine what they might one day accomplish as full-time scientists and clinicians!
Targeting Brain’s Stress Circuitry Curbs Rats’ Alcohol Consumption
Tuesday, August 6, 2019
For social drinkers, alcohol brings to mind barbecues and bar-hopping with friends, but for the roughly 16 million Americans with alcohol use disorder (AUD), drinking is a source of significant stress. Unfortunately, those negative emotions — particularly those experienced during withdrawal — drive people with AUD to drink even more. A recent IRP study points to a potential way to curb the desire to drink in people who abuse alcohol by altering the behavior of a brain structure that governs negative emotions.
Neuroimaging Could Help Tailor Treatment for Amputees
Tuesday, July 23, 2019
Our brains frequently cause us to perceive things that are not real, from high-pitched ringing in an empty room to dancing spots in our vision after staring at a bright light. Even more strangely, people with phantom limb syndrome feel sensations, including pain, in arms and legs that they no longer have. New IRP research into the brain mechanisms underlying phantom limb pain could help hone treatment for individuals living with the condition.
IRP Study Suggests a Way to Prevent Unhealthy Fat Buildup
Tuesday, July 9, 2019
Many important scientific discoveries happen when a scientist stumbles across something curious and decides to investigate further. Alexander Fleming, for example, famously discovered penicillin by examining mold that grew in one of his petri dishes while he was away on vacation. A recent IRP study spurred by a similarly unexpected observation could eventually lead to a method of preventing or reversing unhealthy amounts of fat storage in the liver.