Biomarker Discovery Could Aid Diagnosis and Therapeutic Development
Tuesday, February 16, 2021
Our cells can’t afford to be wasteful, so they prefer to recycle broken components. However, when the mitochondria that provide their energy are damaged beyond repair, cells may have no choice but to throw them out. New IRP research suggests that more of this mitochondrial debris floats in the blood of patients with Alzheimer’s disease, potentially providing an easy, cost-effective way to diagnose or even possibly predict the illness.
IRP Researcher Nancy Sullivan Led Development of Cutting-Edge Treatment
Wednesday, February 10, 2021
Twenty-four years before the novel coronavirus began spreading in Wuhan, China, an outbreak of another deadly virus burned through the city of Kikwit in what is now the Democratic Republic of Congo. Between January and August of 1995, 316 people are thought to have contracted Ebola, and 252 of them died. More than a decade later, a team of NIH infectious disease scientists would track down one of the survivors and use a sample of the individual’s blood to produce one of the first effective treatments for Ebola.
IRP Study Could Help Identify Women at Greater Risk for Fertility Problems
Tuesday, February 2, 2021
As the calendar page turned from 2020 to 2021, many people adopted major lifestyle changes like healthier eating or significantly increasing their physical activity. While these New Year’s resolutions will likely improve their overall health, they could also wreak havoc on the reproductive cycles of a small set of women. New IRP research sheds light on the genetic factors that make some women susceptible to diet- or exercise-induced disruptions to their reproductive systems.
IRP Study Examines Less Time-Intensive Method for Improving Mental Health
Tuesday, January 5, 2021
While working in healthcare can be extremely rewarding, it is also undoubtedly stressful. In particular, the COVID-19 pandemic has had severe repercussions on the mental health of medical professionals, as doctors and nurses struggle to care for unprecedented numbers of sick patients. Fortunately, new NIH research suggests that a relatively brief workplace mindfulness program can reduce stress and anxiety in healthcare workers.
Program Gives Boost to Early Stage Investigators
Monday, December 14, 2020
If TV shows like The Voice and America’s Got Talent are any indication, there are many extremely talented people out there who could become huge successes if presented with the right opportunity. This is no less the case in science, with thousands of extremely bright individuals quietly toiling away in their mentors’ labs as they await the chance to establish research programs of their own.
Fortunately, initiatives like the NIH’s Lasker Clinical Research Scholars Program exist to boost promising young researchers on to the next stage of their careers. Every year, the Lasker program allows a small group of early stage physician-scientists to establish their own labs at the NIH and carry out independent clinical research there for at least five years.
The five talented investigators selected as 2020 Lasker Scholars are pursuing a wide range of research questions, from how the immune system influences blood clotting to the mechanisms driving a rare and devastating skeletal disorder. Read on to learn more about the latest crop of researchers ramping up IRP labs of their very own.
IRP Research Overturns Common Concerns About ‘Weight Cycling’
Tuesday, December 8, 2020
With 2021 less than a month away, many of the more than 200 million Americans who are overweight or obese are beginning to consider making weight loss their New Year’s resolutions — perhaps not for the first time. While trying to lose weight only to ultimately regain it may be disappointing, a new IRP study suggests that repeated attempts at weight loss significantly reduce a person’s risk of dying.
Inhibiting Energy Production Pathway Delays Tumor Formation in Mice
Tuesday, November 10, 2020
Despite the common misconception that sugary treats send kids bouncing off the walls, fat actually provides more than twice as much energy as sugar and other carbohydrates. This energy can be a double-edged sword, fueling not just healthy cells but also cancerous ones. A new IRP study in mice suggests that reducing the body’s ability to burn fat molecules for energy could slow the formation of tumors, potentially extending the lives of individuals with strong genetic predispositions to cancer.
First-Trimester Blood Analysis Could Enable Earlier, More Effective Intervention
Tuesday, October 20, 2020
Imagine a world in which pregnant women routinely travel to places of healing and meet with wise sages who examine a bit of their blood to divine when their babies will be born. While this may sound like something out of Greek mythology, it may soon become a reality, as IRP researchers have developed a test that was able to use blood samples taken early in pregnancy to identify women who would later deliver their babies prematurely.
‘Silicon Valley Nobel’ Recognizes Groundbreaking Parkinson’s Disease Research
Tuesday, October 6, 2020
It can be easy to underestimate the value of so-called ‘basic science’ that doesn’t appear, upon first glance, to have clear therapeutic applications. One of the hidden strengths of this sort of work is its ability to link seemingly disparate areas of scientific inquiry by identifying commonalities between the structure or behavior of different biological molecules. By following these unexpected connections over the course of his career, IRP senior investigator Richard Youle, Ph.D., has made critical discoveries about Parkinson’s disease — research that this year earned him the prestigious Breakthrough Prize in Life Sciences.
Mouse Study Suggests Common Fungus Could Worsen Respiratory Infections
Tuesday, September 29, 2020
Throughout the COVID-19 pandemic, both scientists and the media have focused on the factors that influence who experiences mild symptoms or none at all and who faces potentially life-threatening consequences from the disease. Other respiratory viruses like the flu also have widely varying effects on different patients. New IRP research has found that exposure to a common variety of mold primes the immune system to overreact to the flu virus, dramatically increasing the illness’s severity.