Supercomputing Helps IRP Researchers Complete Our Genetic Blueprints
Monday, April 22, 2019
While the Human Genome Project accomplished a remarkable feat in sequencing all the genes in the human genome, technological limitations still left significant swaths of our genetic blueprints unexplored. Recent advances in DNA sequencing are starting to fill in those gaps, but these new technologies require new computational tools to make sense of the data they generate. That’s where computer scientists like the IRP’s Adam Phillippy, Ph.D., come in.
Study Results Could Help Improve Treatment for Alcohol-Related Problems
Tuesday, April 16, 2019
Your brain is always busy, even when you’re not thinking about anything. Scientists believe the way brain cells communicate with one another when the brain is in that ‘resting state’ might differ in individuals with certain diseases. In a recent study of this idea, IRP researchers found that resting state brain activity could effectively predict the severity of alcohol-related problems.
Computational Biology Research Conducted at NIH Garners $25,000 Prize
Monday, April 8, 2019
The IRP is home to some of today’s and tomorrow’s greatest scientific minds. Hundreds of budding biomedical pioneers begin honing their scientific skills here in high school, but very few win distinction as quickly as seventeen-year-old Daniel Schäffer, whose IRP research earned him inclusion among this year’s 40 finalists in the prestigious Regeneron Science Talent Search.
New System Could Boost Treatment Effectiveness and Curb Side Effects
Tuesday, April 2, 2019
Cancer kills more than half a million men, women, and children each year in the U.S, and chemotherapy is only slightly more discriminating than the disease it treats. As a result, many cancer treatments kill cells throughout the body and cause severe side effects. New IRP research could solve this problem by creating a way to release those toxic compounds only when and where doctors desire.
Discovery Could Lead to New Approaches for Boosting Blood Cell Counts
Tuesday, March 19, 2019
Much of human biology is a black box — scientists know the key players and the end results, but not how those outcomes come about. Consequently, it remains a mystery why some medications help patients. A new IRP study has cracked open the black box to reveal how high levels of an inflammatory molecule inhibit blood cell production in some individuals and why a particular medicine helps reverse this life-threatening condition.
Alternative to CRISPR/Cas9 May Cause Fewer Undesired Changes
Tuesday, March 5, 2019
IRP researchers have always worked on the cutting edge of biomedical science, from testing the first successful treatment for childhood schizophrenia to pioneering the first screening technique for HIV. In a new study, an IRP team recently achieved yet another first: simultaneously editing two genetic sites in mice using a brand-new approach called base editing that may prove to be more precise – and therefore safer – than other gene editing methods.
Thursday, February 28, 2019
The NIH’s main campus in Bethesda, Maryland, may have the look and feel of a university campus, but the world-renowned research institution does not grant credentials like an M.D. or Ph.D. Instead, the Graduate Partnerships Program offers graduate students from schools around the world the opportunity to complete research for their Ph.D. dissertations in IRP labs while pursuing advanced degrees from their ‘host’ institutions.
Delivery Method Could Eventually Help Correct Mutations That Cause Hearing Loss
Tuesday, February 19, 2019
Most people probably think of viruses as villains that bring illnesses like measles, HIV, and the flu, but some viruses are proving to be valuable allies in the fight against genetic diseases. In a new study, a team of scientists from the NIH IRP and their colleagues showed the promise of a lab-designed virus for delivering gene therapies aimed at correcting hereditary hearing loss.
Potential biomarker may contribute to personalized treatments
Tuesday, February 5, 2019
Until recently, medical treatment has largely been one-size-fits-all, with doctors unable to separate patients into distinct groups that might benefit more or less from a particular approach. However, researchers are increasingly finding that individuals with the same disease can differ markedly in ways that might one day influence their care. A recent IRP study has identified a particular molecule that may have just such an impact for patients with damaged lungs.
Tuesday, January 29, 2019
Virtually all parents would agree that having kids is a massive undertaking, and not just after they’re born. Many couples struggle to conceive, and each year thousands of American women experience complications when giving birth. With the help of the NIH’s state-of-the-art supercomputer, Biowulf, IRP senior investigator Rajeshwari Sundaram, Ph.D., develops and refines statistical tools that can guide prospective parents and their doctors through these challenges.