Wednesday, May 20, 2015
If you’ve ever skipped meals for a whole day or gone on a strict, low-calorie diet, you know just how powerful the feeling of hunger can be. Your stomach may growl and rumble, but, ultimately, it’s your brain that signals when to start eating—and when to stop. So, learning more about the brain’s complex role in controlling appetite is crucial to efforts to develop better ways of helping the millions of Americans afflicted with obesity.
Monday, May 18, 2015
As a child I liked robots. Growing up in Korea, I liked cartoons and movies where people were on a mission to save the world with the robots they invented, and I wanted to develop a superhero robot someday, too. While my robot isn’t yet complete, the path I followed in pursuit of my goals eventually led me to explore data analysis.
And here I am, a postdoc at the NIH—probably the largest healthcare research institution in the world—in the Imaging Biomarkers and Computer-Aided Diagnosis Laboratory led by Dr. Ronald M. Summers. Our lab is part of the Department of Radiology and Imaging Sciences at the NIH Clinical Center.
Friday, May 8, 2015
Using real-time MRI, Dr. Keith Horvath's group at the NIH's National Heart, Lung, and Blood Institute (NHLBI) can precisely implant a replacement porcine heart valve using a collapsible stent more safely and quickly than with standard techniques.
"The reason for using [real-time] MRI is three-fold," Dr. Horvath explains...
Monday, May 4, 2015
When I was growing up, my grandfather would visit and try to teach me thermodynamics. At the time, I thought that this was normal conversation between a grandfather and a little girl. It was several years before I realized that he was an eminent scientist in his home country. My grandfather would always ask me, “How is your science?”
Monday, April 20, 2015
Ever since the discovery of the double-helix structure of DNA, scientists have sought ways to edit the genome. Altering gene expression partially and transiently via small interfering RNA has come a long way, and the progress has been spectacular. However, achieving complete and sustained modification of gene expression in a cell remains a tedious procedure that is often costly and time-consuming. For molecular biologists working with cell lines, quick and efficient knock out of one or more genes would provide a powerful tool for their studies. The CRISPR technology arrived two years ago to potentially fulfill that need.
Monday, April 13, 2015
Monitoring cell movement. Examining the microenvironment of a tumor. Mapping a gene. Scientists at the NCI Center for Cancer Research (CCR)—the intramural research program at the National Cancer Institute—use a wide variety of microscopy techniques to observe and probe the otherwise invisible processes that drive cancer at the molecular level.
Friday, April 10, 2015
The cover is stained, the binding is broken, and the edges are burnt from use at a laboratory bench. Practical Pathology by Sir German Sims Woodhead, 3rd ed., 1892, belonged in the library of the original Hygienic Laboratory, which became the NIH in 1930. Although it has seen hard use in its 123 years, this book is now in the NIH Stetten Museum collection and begins a month showcasing some of our recent accessions.
Tuesday, March 17, 2015
The brain’s complexity and how its coordinated actions of billions of neurons shape our behavior and cognition have always fascinated me. So, I decided to go into neuroscience as a career and contribute to biomedical science.
Friday, March 13, 2015
Each day, hundreds of thousands of biomedical researchers around the world design and execute studies, with diverse trajectories and outcomes and where success is based largely on reproducibility. However, a large percentage of experiments using cell culture techniques have been labelled as irreproducible, with around 25 percent of all cell-line research described as either contaminated with other cells or mischaracterized in some way. In other words, if your kidney cancer cell isn’t really a kidney cancer line, then how will anyone else be able to reproduce your work?
Wednesday, March 4, 2015
“Know your enemy” describes the work of Dr. Sarah Branham (1888-1962). She dedicated much of her career to understanding meningitis, identifying different strains, and developing the effective tests and treatments for the disease in anti-serum and sulfa drugs.
In this September 1937 photo, Branham and technician Robert Forkish inoculate a mouse with meningococcus antiserum to determine whether it will protect against meningitis: