Experimental Treatment Curbs Autoimmune Eye Disease in Mice
Tuesday, August 11, 2020
Our cells produce a wide range of chemicals necessary for good health, but when they cannot manufacture enough of these substances, scientists can use cells cultivated in their labs to pick up the slack. In a promising example of this approach, IRP scientists stimulated lab-grown immune cells to produce tiny bundles of an important anti-inflammatory molecule and used those packages to successfully treat a potentially blinding autoimmune disease in mice.
The IRP’s Mario Roederer and Robert Seder Discuss the Science Behind the Headlines
Monday, March 23, 2020
Some say that if something’s not broken, then don’t fix it, but that doesn’t mean there’s no room for improvement. At least, those were the thoughts of IRP senior investigators Mario Roederer, Ph.D., and Robert Alan Seder, M.D., who recently found that the century-old tuberculosis (TB) vaccine is far more effective when administered via injection into a vein (IV) rather than into the skin, which has long been the standard way it is given. This major breakthrough received extensive media coverage, including a story in the New York Times. We went Behind the Headlines to get the inside scoop on this potentially life-saving discovery.
Four Questions with Dr. Niki Moutsopoulos
Friday, March 20, 2020
Our mouths are teeming with bacteria, a microbial ecosystem known as the oral microbiome. While these microbes are typically benign, under certain circumstances they can turn harmful and contribute to oral diseases such as periodontitis, a form of chronic gum disease characterized by microbe-driven inflammation of the soft tissues and bone that support our teeth. According to the Centers for Disease Control and Prevention (CDC), roughly 65 million Americans aged 30 or older have some degree of periodontitis. In its early stage, known as gingivitis, the gums become swollen and red due to inflammation, which is the body’s natural response to the presence of bacteria. If the condition worsens, it can lead to loose teeth and, eventually, bone or tooth loss.
NIH senior investigator Niki Moutsopoulos, Ph.D., head of the Oral Immunity and Inflammation Section at the National Institute of Dental and Craniofacial Research (NIDCR), studies periodontitis and aims to understand the immune system’s role in driving this destruction. In a 2018 study, she and her team of IRP researchers and outside collaborators discovered that an abnormal and unhealthy population of microbes in the mouth causes specialized immune cells, known as T helper 17 (Th17) cells, to trigger inflammation and destroy tissue, leading to periodontitis.
Annual Event Shares Research by IRP’s Summer Interns
Tuesday, August 13, 2019
NIH’s Natcher Conference Center was packed once again last Thursday for the annual Summer Poster Day. This year, more than 1,200 college and high school students spent their summer performing research in an IRP lab through the NIH’s Summer Internship Program.
I navigated through the more than 900 posters presented this year to get a taste of the impressive work done by these young men and women in less than three months. If they can make these kinds of discoveries in just one summer, imagine what they might one day accomplish as full-time scientists and clinicians!
A Conversation with Dr. Paolo Lusso
Thursday, June 27, 2019
First discovered in 1981, human immunodeficiency virus, or HIV, caused one of the most deadly and persistent epidemics in history. HIV destroys CD4+ T cells, a type of white blood cell essential for fighting infection. In doing so, HIV destroys the body’s ability to fight off disease, which often leads to life-threatening consequences.
Today, medications have allowed people living with HIV to lead healthier lives. However, HIV still remains a major public health concern and continues to be studied by researchers within the IRP and beyond.
IRP research has produced findings essential to the development of current HIV treatments and tools for diagnosis. However, there is still a lot left to learn. One recent IRP contribution to HIV research was a 2017 study led by IRP senior investigator Paolo Lusso, M.D., Ph.D., which suggests that treatments targeting a protein called integrin α4β7 could potentially become an addition to current treatment options for those with HIV, or provide new measures to prevent infection.
New Insights Could Help Reduce Premature Births
Tuesday, May 28, 2019
Any baby born less than 37 weeks after conception is considered premature, but not all premature births have the same root cause. In a new study, IRP researchers have detailed how a particular component of the immune system can trigger premature labor, which could help doctors prevent more preterm births.
Drug Candidate Calms Overzealous Immune Response in the Eye
Tuesday, April 30, 2019
Our immune cells don’t like strangers and attack many organisms and substances that they have never seen before, including harmless ones. In autoimmune diseases, this reaction gets out of hand and our own cells are caught in the crossfire. IRP scientists have found that a new therapeutic compound can curb this sort of autoimmune carnage in the eye.
Tuesday, March 26, 2019
As Women's History month draws to a close, we’d like to introduce you to some of the IRP researchers who have received the honor of delivering the Anita B. Roberts Lecture. The Anita B. Roberts Lecture Series is organized by the NIH Women Scientist Advisors Committee to highlight outstanding research achievements by female scientists at NIH. The series is supported by the Office of Research on Women’s Health.
Tuesday, September 11, 2018
Between fast-food outlets, vending machines, and food trucks — not to mention good old-fashioned home cooking — many people face no shortage of opportunities to eat. But as satisfying as a crisp potato chip or a moist pork chop may be, people with asthma and many other conditions may prefer to resist tasty temptations if it means alleviating some of their symptoms. In a small pilot study, IRP researchers found evidence that abstaining from food for 24 hours could inhibit some of the cellular processes that cause asthmatics’ breathing problems.
Tuesday, July 17, 2018
The constant combat between cancer and the body’s defenses can wear a tumor out. Unfortunately, cancer cells can pause their life cycle to repair themselves before re-entering the fray with renewed vigor. According to new IRP research, preventing cancer from taking a time-out can make it more susceptible to attack by the immune system.