IRP Research Overturns Common Concerns About ‘Weight Cycling’
With 2021 less than a month away, many of the more than 200 million Americans who are overweight or obese are beginning to consider making weight loss their New Year’s resolutions — perhaps not for the first time. While trying to lose weight only to ultimately regain it may be disappointing, a new IRP study suggests that repeated attempts at weight loss significantly reduce a person’s risk of dying.
Sugar Molecule Protects Mice Against Type 1 Diabetes
Avoiding too much sugar is one of the cardinal rules for those who have or are at risk for diabetes. In fact, diabetes is characterized by having too much glucose, a form of sugar, in the blood. As a result, it came as quite a surprise to IRP researchers led by senior investigator Wanjun Chen, M.D., when they discovered that a particular form of sugar that they expected to have no effect on diabetes-prone mice actually protected them from developing type 1 diabetes.
NIH Researcher Recognized for Advances in Brain Imaging
The National Academy of Engineering (NAE), established in 1964, comprises more than 2,000 peer-elected members who are among the world’s most accomplished engineers, including senior professionals in business, academia, and government.
IRP senior investigator Peter Basser, Ph.D., was elected to the NAE in February 2020. He directs the Section on Quantitative Imaging and Tissue Science and the Division of Translational Imaging and Genomic Integrity in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), where he studies how the structure and material properties of living tissues affect their function.
Inhibiting Energy Production Pathway Delays Tumor Formation in Mice
Despite the common misconception that sugary treats send kids bouncing off the walls, fat actually provides more than twice as much energy as sugar and other carbohydrates. This energy can be a double-edged sword, fueling not just healthy cells but also cancerous ones. A new IRP study in mice suggests that reducing the body’s ability to burn fat molecules for energy could slow the formation of tumors, potentially extending the lives of individuals with strong genetic predispositions to cancer.
Photos Show Evolution of Pre-Eminent Research Institution
In just one lifetime, the NIH's main campus in Bethesda, Maryland, went from country estate to one of the premiere biomedical research campuses in the world. October 31, 2020, marked the 80th anniversary of the dedication of the NIH campus by President Franklin D. Roosevelt, who said, “Today the need for the conservation of health and physical fitness is greater than at any time in the Nation's history. In dedicating this institute, I dedicate it to the underlying philosophy of public health, to the conservation of life, to the wise use of the vital resources of our Nation. I voice for America, and for the stricken world, our hopes, our prayers, our faith, in the power of man's humanity to man.”
In honor of that historic milestone, I have gathered a collection of old photos and fun facts to provide a taste of how NIH's Bethesda campus has changed over the past 80 years. Who knows how this cutting-edge biomedical research institution might change over the next eight decades?
Genetic Studies Illuminate Neuronal Chemical’s Role in Pain and Itch
For most of us, itch is a bothersome inconvenience. Unfortunately, for 125 million people around the world, chronic itch caused by the skin disease psoriasis is a significant, even debilitating, health problem. Psoriasis causes skin cells to multiply up to 10 times faster than normal and build up as an itchy and painful, scaly rash. For some, the condition can also cause joint swelling, resulting in a condition known as ‘psoriatic arthritis.’
World Psoriasis Day falls on October 29 this year, and the theme is “Be Informed.” So, what do we know about chronic itch?
NIH Researcher Recognized for Investigation into the Skin Microbiome
The National Academy of Medicine (NAM), first established in 1970 by the National Academy of Sciences as the Institute of Medicine (IOM), is comprised of more than 2,000 elected members from around the world who provide scientific and policy guidance on important matters relating to human health. Election to the NAM is considered one of the highest honors in the fields of health and medicine that recognizes individuals who have not only made critical scientific discoveries but have also demonstrated a laudable commitment to public service.
IRP senior investigator Julie Segre, Ph.D., was one of four IRP researchers elected to the NAM in 2019. Dr. Segre leads the Translational and Functional Genomics Branch at the National Human Genome Research Institute (NHGRI), where she studies the way in which the skin forms a barrier between the body and the environment. In particular, her research uses genetic sequencing to understand the bacterial and fungal microbes that live on human skin.
First-Trimester Blood Analysis Could Enable Earlier, More Effective Intervention
Imagine a world in which pregnant women routinely travel to places of healing and meet with wise sages who examine a bit of their blood to divine when their babies will be born. While this may sound like something out of Greek mythology, it may soon become a reality, as IRP researchers have developed a test that was able to use blood samples taken early in pregnancy to identify women who would later deliver their babies prematurely.
NIH History Office Explores Life During a Pandemic
The NIH has played a critical role in supporting research and therapeutic development aimed at curbing the spread of the novel coronavirus that causes COVID-19. The people doing that important work have had their lives changed by the pandemic in many ways. For that reason, the Office of NIH History and Stetten Museum has launched an initiative to encourage NIH employees and volunteers to share their professional and personal experiences during the COVID-19 pandemic. These contributions will be the primary source material future historians will use to understand how NIH fared and adapted at this critical time.
‘Silicon Valley Nobel’ Recognizes Groundbreaking Parkinson’s Disease Research
It can be easy to underestimate the value of so-called ‘basic science’ that doesn’t appear, upon first glance, to have clear therapeutic applications. One of the hidden strengths of this sort of work is its ability to link seemingly disparate areas of scientific inquiry by identifying commonalities between the structure or behavior of different biological molecules. By following these unexpected connections over the course of his career, IRP senior investigator Richard Youle, Ph.D., has made critical discoveries about Parkinson’s disease — research that this year earned him the prestigious Breakthrough Prize in Life Sciences.
This page was last updated on Friday, January 14, 2022
