Mouse Study Supports Potential Treatment Approach for Numerous Neurological Diseases
Tuesday, November 12, 2019
Winter is fast approaching, bringing with it both picturesque snow flurries and raging blizzards. It's a good reminder that something that is desirable in moderate amounts can be downright dangerous in large quantities, and the systems that keep our cells healthy are no different. IRP researchers recently found a novel way to tamp down a runaway cellular process that can kill neurons, findings that may one day lead to new treatments for several debilitating neurological conditions.
Experimental Approach Predicts Future Alzheimer’s Diagnoses
Tuesday, October 15, 2019
If you looked through my garbage, you would probably find a litany of apple cores (my favorite fruit) and a couple fundraising requests from my alma mater. Similarly, scientists can learn a lot about what is going on in cells by examining their trash. IRP researchers recently developed a blood test that may be able to predict Alzheimer’s disease years before the onset of symptoms by examining packages of waste products from neurons.
Five Questions with Dr. Catherine Bushnell
Monday, September 9, 2019
Yoga is all the rage these days, with millions of people taking part in the practice for relaxation, meditation, and increasing flexibility and muscle strength. However, the benefits of yoga go beyond what most might think. In fact, the mind-body practice of yoga could have a significant impact on the lives of those living with chronic pain, a condition that affects tens of millions of Americans.
In the past, doctors often prescribed opioids to treat chronic pain. However, research has shown that people with chronic pain have anatomical and neurochemical alterations in the brain that make them less responsive to opioids. In addition, both the medical and political systems are currently contending with a public health crisis stemming from the over-use of opioid pain medications. As a result, researchers have been working to identify ways to better manage chronic pain, particularly without the use of medication.
Annual Event Shares Research by IRP’s Summer Interns
Tuesday, August 13, 2019
NIH’s Natcher Conference Center was packed once again last Thursday for the annual Summer Poster Day. This year, more than 1,200 college and high school students spent their summer performing research in an IRP lab through the NIH’s Summer Internship Program.
I navigated through the more than 900 posters presented this year to get a taste of the impressive work done by these young men and women in less than three months. If they can make these kinds of discoveries in just one summer, imagine what they might one day accomplish as full-time scientists and clinicians!
Targeting Brain’s Stress Circuitry Curbs Rats’ Alcohol Consumption
Tuesday, August 6, 2019
For social drinkers, alcohol brings to mind barbecues and bar-hopping with friends, but for the roughly 16 million Americans with alcohol use disorder (AUD), drinking is a source of significant stress. Unfortunately, those negative emotions — particularly those experienced during withdrawal — drive people with AUD to drink even more. A recent IRP study points to a potential way to curb the desire to drink in people who abuse alcohol by altering the behavior of a brain structure that governs negative emotions.
Neuroimaging Could Help Tailor Treatment for Amputees
Tuesday, July 23, 2019
Our brains frequently cause us to perceive things that are not real, from high-pitched ringing in an empty room to dancing spots in our vision after staring at a bright light. Even more strangely, people with phantom limb syndrome feel sensations, including pain, in arms and legs that they no longer have. New IRP research into the brain mechanisms underlying phantom limb pain could help hone treatment for individuals living with the condition.
Five Questions With Dr. Jessica Gill
Wednesday, July 17, 2019
Each year, millions of Americans suffer sports-related concussions, and the number of youth suffering from these traumatic brain injuries has been rising. Blows to the head are common in sports such as football and hockey, and when these forces are strong enough to cause a concussion, they can harm the brain and impair cognitive functioning. Although concussions occur in staggering numbers, scientists do not fully understand what happens to the brain at the time of concussion or during the recovery period. However, that doesn’t mean they’re not trying.
IRP Investigator Bevil Conway Discusses the Science Behind the Headlines
Monday, July 15, 2019
What started as a friendly bet between investigators soon produced a major scientific discovery that calls into question the long-standing notion that non-human primates serve as accurate models for the way human brains function. The study, conducted by IRP investigator Bevil Conway, Ph.D., made headlines recently with reports in outlets such as NPR and U.S. News and World Report. We’re going Behind the Headlines with Dr. Conway to dive deeper into the story, understand the significance of his findings, and see where his work could lead.
A Conversation with Dr. Lori Beason-Held
Tuesday, June 18, 2019
Expert estimates suggest that more than 5.5 million Americans may have dementia caused by Alzheimer’s, a disease currently ranked as the sixth-leading cause of death in the United States. Because of the condition’s growing prevalence and profound consequences for patients, understanding Alzheimer’s disease and other forms of cognitive decline is an important goal within the Intramural Research Program.
One example of the IRP’s many contributions to the field of Alzheimer’s research is a 2013 study that detected brain changes in older adults who would go on to develop cognitive impairment years before their memory began to fail. This research, led by IRP staff scientist Lori Beason-Held, Ph.D., aimed to understand who might be susceptible to developing Alzheimer’s disease and what factors contribute to the development of the disease before symptoms appear.
New Technique Overcomes Major Obstacle to Stem-Cell-Based Treatments
Tuesday, May 14, 2019
Your brain cells need plenty of oxygen and nutrients to survive — that is, unless you’re a hibernating ground squirrel. By tapping into the cellular process that keeps these animals’ brains healthy during the long winter months, IRP scientists have discovered a way to increase the survival of neuron-producing stem cells implanted into the brain after a stroke, a development that could one day dramatically improve stroke treatment.