Approach Could Protect or Even Regenerate Neurons in Eye and Spinal Cord
Tuesday, August 24, 2021
At the end of Aesop’s fable The Lion and the Mouse, the titular rodent saves his much larger friend from a hunter’s trap. Just like Aesop, scientists know well that even something tiny and often overlooked can lend a helping hand. Extremely short strands of genetic material called microRNAs, for instance, could make for useful therapeutic targets for glaucoma and other degenerative eye ailments, according to new IRP research.
Individuals From Around the World Drive IRP Breakthroughs
Wednesday, August 11, 2021
Come to NIH and you’ll hear many accents. Scientists from around the world have always contributed significantly to the NIH mission. The resulting diversity of backgrounds and perspectives makes the NIH Intramural Research Program an extremely stimulating and productive environment. Read on to learn about some of the many scientists of the past and present who brought their talents from abroad to one of the world’s leading institutions for biomedical research.
Future Physician-Scientists Spent a Year in IRP Labs
Monday, September 21, 2020
Many doctors not only treat patients directly, but also make valuable contributions to research that will improve medical care in the future. Each one of these talented ‘physician-scientists’ began his or her research career under the guidance of a more senior scientist. At the NIH, the Medical Research Scholars Program (MRSP) provides just such an experience to promising young medical students from all across the United States.
Experimental Treatment Curbs Autoimmune Eye Disease in Mice
Tuesday, August 11, 2020
Our cells produce a wide range of chemicals necessary for good health, but when they cannot manufacture enough of these substances, scientists can use cells cultivated in their labs to pick up the slack. In a promising example of this approach, IRP scientists stimulated lab-grown immune cells to produce tiny bundles of an important anti-inflammatory molecule and used those packages to successfully treat a potentially blinding autoimmune disease in mice.
Annual Event Shares Research by IRP’s Summer Interns
Tuesday, August 13, 2019
NIH’s Natcher Conference Center was packed once again last Thursday for the annual Summer Poster Day. This year, more than 1,200 college and high school students spent their summer performing research in an IRP lab through the NIH’s Summer Internship Program.
I navigated through the more than 900 posters presented this year to get a taste of the impressive work done by these young men and women in less than three months. If they can make these kinds of discoveries in just one summer, imagine what they might one day accomplish as full-time scientists and clinicians!
Drug Candidate Calms Overzealous Immune Response in the Eye
Tuesday, April 30, 2019
Our immune cells don’t like strangers and attack many organisms and substances that they have never seen before, including harmless ones. In autoimmune diseases, this reaction gets out of hand and our own cells are caught in the crossfire. IRP scientists have found that a new therapeutic compound can curb this sort of autoimmune carnage in the eye.
Thursday, February 28, 2019
The NIH’s main campus in Bethesda, Maryland, may have the look and feel of a university campus, but the world-renowned research institution does not grant credentials like an M.D. or Ph.D. Instead, the Graduate Partnerships Program offers graduate students from schools around the world the opportunity to complete research for their Ph.D. dissertations in IRP labs while pursuing advanced degrees from their ‘host’ institutions.
Monday, July 23, 2018
I knew very little about neuroscience before beginning my graduate studies, but the topic of neurodegeneration looked very interesting. Having applied to several labs, I landed a Ph.D. student position in a neuroscience lab at the Saha Institute of Nuclear Physics, a government research institute in India, that would propel me on my way to the NIH IRP. In the first year of my Ph.D. program, I learned several things about the central nervous system (CNS), but what intrigued me the most was its lack of ability to regenerate after injury.
Tuesday, June 7, 2016
Last month we lost a remarkable investigator, Robert Nussenblatt, M.D., M.P.H., chief of the Laboratory of Immunology at the National Eye Institute (NEI). Bob was a world-renowned expert in uveitis, an inflammatory eye disease and a leading cause of blindness in younger people. He was instrumental in establishing the pathology of and treatment for uveitis. Bob was diagnosed with a metastatic cancer just a few months ago. He remained characteristically optimistic even as his prognosis rapidly grew worse. He died on April 17, 2016, at age 67 with his family by his side. The NIH staff just devastated to hear the news of his death, because so few knew Bob was ill.