eye

Scouting Out Summer Poster Day

Annual Event Held In-Person for First Time in Four Years

Amia Black poses with her poster at Summer Poster Day

A few weeks ago, NIH’s Natcher Conference Center bustled with the youthful scientific enthusiasm of IRP summer interns for the first time since 2019, the last time that the IRP’s Summer Poster Day was held in-person. At this year’s event, held on August 3 and 4, the hundreds of high school and college students who conducted research in IRP labs as part of NIH’s Summer Internship Program this year eagerly showed off the fruits of their labors — from discoveries about how weight loss drugs affect the brain to new insights into a potential treatment target for age-related vision loss. Read on to learn more about a few of these scientific upstarts and the research revelations they’ve helped uncover.

Out of the Clinic and Into the Lab

Visiting Medical Students Look Back on IRP Research Experience

Alex Valenzuela

When patients are affected by complex and poorly understood medical problems, it can only be an advantage when their doctors have one foot in the exam room and another in a laboratory studying the disease. However, physicians don’t accrue scientific skills on their own. Rather, they often must venture outside of their medical education to gain experience in research via programs like NIH’s Medical Research Scholars Program (MRSP).

The MRSP allows medical students from across the United States to spend a year working in IRP labs alongside seasoned scientists. The 50 medical students and one dental student selected as 2022 Medical Research Scholars recently finished their time at NIH after arriving on campus last July. Between classes, clinical rounds, study sessions, and exams, five of those young men and women found the time to describe their experience at NIH to the “I Am Intramural” blog, so read on to get a taste of what the MRSP has to offer our nation’s aspiring physicians.

Poster Session Showcases IRP Graduate Students

Event Includes In-Person Presentations for First Time Since 2020

people looking at posters at the 2023 NIH Graduate Student Research Symposium poster session

Three years after COVID-19 dramatically changed the way scientists and many others work, much of life in the NIH IRP has begun to resemble the way things were in February of 2020. This includes the return of in-person scientific poster sessions like the one that took place on February 16 as part of the 19th annual NIH Graduate Student Research Symposium. Nearly 130 graduate students conducting their Ph.D. research in IRP labs as part of NIH’s Graduate Partnership Program presented their progress at that poster session and its virtual counterpart held February 15.

The two poster sessions made it clear that IRP graduate students are essential contributors to the life-changing discoveries made at NIH, from using geckos to learn about human eye diseases to investigating how the immune system combats infectious invaders to exploring ways to improve cancer treatment. Keep reading to learn about some of the bright scientists-in-training who showed off their work during the two-day event.

Postdoc Profile: A Bird’s-Eye View of Retinal Disease

Dr. Noor White Traces Evolution to Identify Genes Critical for Vision

Dr. Noor White

The eye has existed in some form for roughly 600 million years. Its many intricate components and the general ability of organisms to sense light have continued to adapt and evolve over huge spans of time into what we know as vision today. By mapping out the evolution of vision, Noor White, Ph.D., hopes to shed light on the genetic causes of diseases that affect the retina, the part of the eye that turns light into electrical signals the brain can use to build an image of our surroundings.

“If we can take a step back and look at the bigger picture, then we can identify the critical genetic components of vision,” explains Dr. White, who was an IRP postdoctoral fellow for four years before becoming a Staff Scientist in March.

New Lasker Scholars Begin Breaking New Ground

Early-Career Scientists Power Through Pandemic to Launch Labs

NIH’s 2021 Lasker Clinical Research Scholars

NIH has long prided itself on its ability to accelerate the careers of the brightest young physicians and scientists in the country. One of these many efforts is the Lasker Clinical Research Scholars Program, which provides a select group of individuals relatively early in their scientific careers with the funding and institutional support to start their own labs at NIH. After five to seven years of independent research in the IRP, Lasker Scholars are given the option to apply for three years of funding for work outside of NIH or to remain as investigators at NIH.

While launching a lab in the midst of a global pandemic is no easy task, five Lasker Scholars have done just that over the past year. Their research on cancer, Parkinson’s disease, childhood blindness, and inflammatory conditions is now well underway and promises to eventually improve the lives of many patients. Keep reading to learn more about how NIH’s newest Lasker Scholars are changing the way we treat those illnesses.

Tiny Molecules Have Big Potential for Treating Eye Diseases

Approach Could Protect or Even Regenerate Neurons in Eye and Spinal Cord

eye

At the end of Aesop’s fable The Lion and the Mouse, the titular rodent saves his much larger friend from a hunter’s trap. Just like Aesop, scientists know well that even something tiny and often overlooked can lend a helping hand. Extremely short strands of genetic material called microRNAs, for instance, could make for useful therapeutic targets for glaucoma and other degenerative eye ailments, according to new IRP research.

Global Scientists Come Together at the National Institutes of Health

Individuals From Around the World Drive IRP Breakthroughs

Dr. Flossie Wong-Staal

Come to NIH and you’ll hear many accents. Scientists from around the world have always contributed significantly to the NIH mission. The resulting diversity of backgrounds and perspectives makes the NIH Intramural Research Program an extremely stimulating and productive environment. Read on to learn about some of the many scientists of the past and present who brought their talents from abroad to one of the world’s leading institutions for biomedical research.

Medical Research Scholars Reflect on Their NIH Journeys

Future Physician-Scientists Spent a Year in IRP Labs

MRSP participant working in the lab

Many doctors not only treat patients directly, but also make valuable contributions to research that will improve medical care in the future. Each one of these talented ‘physician-scientists’ began his or her research career under the guidance of a more senior scientist. At the NIH, the Medical Research Scholars Program (MRSP) provides just such an experience to promising young medical students from all across the United States.

Immune Cells Produce Potent Packages of Anti-Inflammatory Molecule

Experimental Treatment Curbs Autoimmune Eye Disease in Mice

B cell

Our cells produce a wide range of chemicals necessary for good health, but when they cannot manufacture enough of these substances, scientists can use cells cultivated in their labs to pick up the slack. In a promising example of this approach, IRP scientists stimulated lab-grown immune cells to produce tiny bundles of an important anti-inflammatory molecule and used those packages to successfully treat a potentially blinding autoimmune disease in mice.

Poster Day Showcases Summer Student Science

Annual Event Shares Research by IRP’s Summer Interns

IRP summer intern Enat Ayele

NIH’s Natcher Conference Center was packed once again last Thursday for the annual Summer Poster Day. This year, more than 1,200 college and high school students spent their summer performing research in an IRP lab through the NIH’s Summer Internship Program. 

I navigated through the more than 900 posters presented this year to get a taste of the impressive work done by these young men and women in less than three months. If they can make these kinds of discoveries in just one summer, imagine what they might one day accomplish as full-time scientists and clinicians!