Sugar Molecule Protects Mice Against Type 1 Diabetes
Monday, November 23, 2020
Avoiding too much sugar is one of the cardinal rules for those who have or are at risk for diabetes. In fact, diabetes is characterized by having too much glucose, a form of sugar, in the blood. As a result, it came as quite a surprise to IRP researchers led by senior investigator Wanjun Chen, M.D., when they discovered that a particular form of sugar that they expected to have no effect on diabetes-prone mice actually protected them from developing type 1 diabetes.
Hundreds of Young Researchers Present Their Work Online
Wednesday, May 6, 2020
The COVID-19 pandemic has dramatically altered the way scientists are doing their work. Nevertheless, scientific research is a highly collaborative and interactive enterprise, so it remains essential for researchers to share and discuss their ideas and discoveries.
Every spring, the NIH’s Postbac Poster Day offers recent college graduates participating in the NIH’s Postbaccalaureate IRTA program the chance to show off the fruits of their labors and talk about their projects with both their fellow postbacs and the NIH’s many seasoned scientific veterans. Due to the need to maintain social distancing, the NIH's Office of Intramural Training and Education (OITE) went through considerable effort to move this year’s Postbac Poster Day to an online forum. The OITE staff's hard work paid off handsomely, with more than 870 postbacs presenting their research via WebEx on April 28, 29, and 30. Keep reading for a few examples of the fascinating scientific questions NIH’s latest crop of postbacs has been investigating.
Study Suggests New Treatment Strategy for Increasingly Common Disease
Monday, April 6, 2020
In the classic sci-fi film Alien, the protagonist attempts to destroy the titular monster by triggering the self-destruct mechanism on her spaceship. Our cells also sometimes need to destroy themselves in order to circumvent threats like cancer, but uncontrolled cell death can lead to disease. New IRP research suggests that preventing certain cells in the pancreas from tripping their self-destruct switch could help relieve the symptoms of type 2 diabetes.
Exceptional Early-Stage Investigators Push the Boundaries of Translational Research
Thursday, December 5, 2019
Online and print publications are constantly touting momentous discoveries by superstar scientists like CRISPR-Cas9 co-discover Jennifer Doudna or the IRP’s own Kevin Hall, who changed the way we think about weight loss. It can be easy to forget that today’s biomedical pioneers were once young researchers toiling to establish themselves in the competitive environment of modern science.
Each year, a small, exceptionally promising group of scientific up-and-comers become Lasker Clinical Research Scholars through a highly competitive program jointly funded by the NIH and the Albert and Mary Lasker Foundation. The program presents early-stage physician-scientists with the opportunity to carry out independent clinical research at the NIH for five to ten years. The 2019 class of Lasker Scholars consists of five extremely talented researchers who are now beginning a critical new phase in their careers. Let’s meet them.
Therapeutic Strategy Enhances Natural Blood Sugar Control
Tuesday, October 1, 2019
Just like Sonny needed Cher to achieve music super-stardom and Stephen Curry needed Kevin Durant to win back-to-back NBA championships, sometimes a cell or molecule in the human body needs a partner’s assistance to work optimally. IRP researchers recently showed that a synergy between a lab-designed drug and a molecule naturally produced in the body could make for a promising therapy for type 2 diabetes.
Tuesday, December 11, 2018
The more scientists have learned about the community of benign bacteria inside our bodies, known as the microbiome, the more effort they have put into recruiting it in the fight against disease. What’s more, scientists occasionally discover that treatments long thought to work completely independently of our native microbes also relieve symptoms by interacting with them. New IRP research into the most commonly used medication for type 2 diabetes has led to just such a revelation by demonstrating that its benefits stem in part from its ability to kill off a particular species of bacteria in the human digestive tract.
Monday, May 7, 2018
On Wednesday, May 2, hundreds of researchers gathered at NIH’s Natcher Conference Center to show off their recent discoveries. But unlike a typical scientific conference, the letters “M.D.” and “Ph.D.” were noticeably absent from these scientists’ credentials. Instead, the event — NIH’s annual Postbac Poster Day — celebrated the accomplishments of individuals participating in the NIH Postbaccalaureate Intramural Research Training Award (IRTA) Program.
Thursday, March 26, 2015
Phoenix, Arizona, received its name from a British pioneer named Darrell Duppa. When he saw what was left of prehistoric settlements built by the Hohokam civilization thousands of years before his arrival, he knew that another great civilization would “rise from these ashes” just like the mythic bird. The desert city is today home to the Phoenix Epidemiology and Clinical Research Branch, one of six IRP research campuses.
Wednesday, February 4, 2015
On Monday, January 26, about 150 people tackled the Arrowhead 135 ultramarathon, a race through 135 miles of frigid landscape near International Falls, Minnesota. They biked, ran, and skied for almost 70 hours in -30°F air to reach their goal.