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I am Intramural Blog

IRP Discoveries

Exercise Releases Brain-Healthy Protein

Thursday, June 30, 2016

Reblogged from the NIH Director's Blog.

Five images of different exercise activities

We all know that exercise is important for a strong and healthy body. Less appreciated is that exercise seems also to be important for a strong and healthy mind, boosting memory and learning, while possibly delaying age-related cognitive decline. How is this so? Researchers have assembled a growing body of evidence that suggests skeletal muscle cells secrete proteins and other factors into the blood during exercise that have a regenerative effect on the brain.

Collaboration Identifies Role of DNA-PK in Asthma

Tuesday, May 3, 2016

Reblog from the NHLBI Intranet (NIH-only access).

Role of DNA-PK in Asthma

Second in the Orloff Award recipient series are Drs. Jay Chung and Stewart Levine for their characterization of the role of DNA-dependent protein kinase (DNA-PK) in dendritic cell function in asthma and for the identification of the role of pharmacological inhibition of DNA-PK as a novel treatment approach for asthma.

Caffeine's Fine Line Between Cognition and Addiction

Thursday, April 28, 2016

A1RP

Research suggests that two-thirds of U.S. adults drink two or more cups of coffee a day. There are multiple reasons for this, likely because coffee has multiple effects on the body. Consider the standard morning scenario for many people.

Orloff Science Awards Recognize Aplastic Anemia Treatment

Tuesday, March 8, 2016

Reblogged from the NHLBI Intranet (NIH-only access). Originally posted on March 2, 2016.

Cynthia E. Dunbar, MD

From genetic studies to pharmacology, the Orloff Science Awards honor the remarkable work and responsibilities our researchers undertake every day to make a difference in the world—science that truly matters and impacts human health.

Snapshots of Life: Stronger Than It Looks

Tuesday, March 1, 2016

Reblogged from the NIH Director's Blog.

scanning electron micrograph of tooth enamel

If you went out and asked folks what they’re seeing in this picture, most would probably guess an elegantly woven basket, or a soft, downy feather. But what this scanning electron micrograph actually shows isn’t at all soft: it is the hardest substance in the mammalian body—tooth enamel!

Toward an AIDS-Free Generation: Can Antibodies Help?

Thursday, January 28, 2016

Reblogged from the NIH Director's Blog.

VRC01 antibody binding to HIV

This year, an estimated 50,000 Americans will learn they have been newly infected with the human immunodeficiency virus (HIV), which causes AIDS. A new generation of safe, effective, and longer-lasting treatments to keep HIV in check is very much needed.

Taking a “Moonshot” at Cancer

Tuesday, January 26, 2016

In his recent State of the Union address, President Barack Obama called America to action and asserted that our researchers can find the cure for cancer, a sentiment that received a standing ovation. We believe that Obama is right.

Got It Down Cold: Cryo-Electron Microscopy Named Method of the Year

Wednesday, January 20, 2016

Reblogged from the NIH Director's Blog.

In the quest to find faster, better ways of mapping the structure of proteins and other key biological molecules, a growing number of researchers are turning to an innovative method that pushes the idea of a freeze frame to a whole new level: cryo-electron microscopy (cryo-EM).

Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years.

Statisticians Seek Improved Biomarker Utility

Tuesday, December 15, 2015

When you hear “biomarker,” what is the first thing that comes to mind? BRCA1? Fluorescently labeled G-proteins? Those are two well-known examples, but biomarkers (short for “biological markers”) are actually a much broader group of biological signs than just genetic or cellular traits.

Danping Liu and Aiyi Liu

Interdisciplinary Approaches to Addiction Research

Wednesday, October 14, 2015

By bringing together researchers from different disciplines, the IRP tackles some of the biggest questions in science from multiple angles. Here are just a few examples of the many diverse approaches that Intramural scientists take to better understand addiction.

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