Mouse Study Suggests Common Fungus Could Worsen Respiratory Infections
By Brandon Levy
Tuesday, September 29, 2020
Throughout the COVID-19 pandemic, both scientists and the media have focused on the factors that influence who experiences mild symptoms or none at all and who faces potentially life-threatening consequences from the disease. Other respiratory viruses like the flu also have widely varying effects on different patients. New IRP research has found that exposure to a common variety of mold primes the immune system to overreact to the flu virus, dramatically increasing the illness’s severity.
IRP Research Examines Pandemic From All Angles
By Brandon Levy
Tuesday, July 7, 2020
The sheer number of labs and wide variety of scientific perspectives in the IRP make it particularly well-suited to combating a disease like COVID-19, which is affecting patients’ health and the world around them in a huge number of ways. IRP researchers specializing in psychology, genetics, epidemiology, and many other disciplines are pursuing an array of strategies to learn more about the novel coronavirus.
IRP Investigators Begin Hundreds of New Coronavirus-Related Studies
By Brandon Levy
Monday, June 15, 2020
Within just a few months after COVID-19 began spreading in the United States, IRP researchers had already made numerous important contributions to the fight against the deadly virus. Scientific knowledge about the disease continues to expand at a unprecedented pace, and the IRP will continue to play a major role in this effort over the coming months and years. In fact, nearly 300 new intramural research projects related to the novel coronavirus are currently starting up or have already begun.
NIH Researcher Recognized for Enhancing the Molecular Understanding of Immune Responses
By Brooke Worthing
Tuesday, March 3, 2020
The National Academy of Sciences (NAS), established in 1863, is comprised of the United States’ most distinguished scientific scholars, including nearly 500 Nobel Prize winners. Members of the NAS are elected by their peers and entrusted with the responsibility of providing independent, objective advice on national matters related to science and technology in an effort to advance innovations in the United States.
IRP senior investigator Michael Lenardo, M.D., is one of four IRP researchers elected to the NAS over the past two years. At the NIH, Dr. Lenardo serves as Chief of the Molecular Development of the Immune System Section at the NIH’s National Institute of Allergy and Infectious Diseases (NIAID), where he studies how the cells in the immune system mount protective responses to various pathogens, including viruses and bacteria. A major focus of Dr. Lenardo’s work is the investigation of genetic abnormalities in the immune system, which have the potential to cause life-threatening diseases.
Five Questions with Dr. Heidi Kong and Dr. Julia Segre
By Brooke Worthing
Monday, November 25, 2019
When people think of skin health, they often think of protecting it from harmful UV rays or finding ways to avoid the fine lines and wrinkles that often come with aging and sun exposure. However, there are many factors and illnesses that impact skin health, including eczema, a chronic condition that affects tens of millions of Americans and causes the skin to become red and so itchy that it can interfere with patients’ sleep.
To combat such conditions, IRP researchers have spent decades investigating what causes them in humans through techniques such as immunology, genetics, molecular biology, and structural biology. In a 2014 study of healthy volunteers, IRP investigators Julia Segre, Ph.D., and Heidi Kong, M.D., M.H.Sc., used the latest genomic techniques to investigate the collection of microorganisms living on healthy human skin, known as the skin microbiome, in an attempt to understand how this collection of bacteria, fungi, and viruses may contribute to skin health. From their interdisciplinary research, the team was able to show that the array of microbes living on human skin is extremely diverse, varying greatly from individual to individual and between different areas of the body. This research opened doors for additional studies exploring how changes in the skin microbiome contribute to both common and rare skin diseases.
Annual Event Highlights Contributions of IRP Postdoctoral Fellows
By Brandon Levy
Monday, September 16, 2019
At lunchtime last Wednesday, the NIH Clinical Center’s FAES Terrace echoed with the joyful sounds of scientists nourishing their bodies and their brains. While those stopping by the annual NIH Research Festival poster session could be forgiven for making a beeline straight for the food — including the submissions to this year’s Scientific Directors’ baking competition — once their plates were full, they took advantage of the opportunity to satiate their scientific curiosity as well by checking out the dozens of posters on display.
A Conversation with Dr. Paolo Lusso
By Brooke Worthing
Thursday, June 27, 2019
First discovered in 1981, human immunodeficiency virus, or HIV, caused one of the most deadly and persistent epidemics in history. HIV destroys CD4+ T cells, a type of white blood cell essential for fighting infection. In doing so, HIV destroys the body’s ability to fight off disease, which often leads to life-threatening consequences.
Today, medications have allowed people living with HIV to lead healthier lives. However, HIV still remains a major public health concern and continues to be studied by researchers within the IRP and beyond.
IRP research has produced findings essential to the development of current HIV treatments and tools for diagnosis. However, there is still a lot left to learn. One recent IRP contribution to HIV research was a 2017 study led by IRP senior investigator Paolo Lusso, M.D., Ph.D., which suggests that treatments targeting a protein called integrin α4β7 could potentially become an addition to current treatment options for those with HIV, or provide new measures to prevent infection.
By Brandon Levy
Tuesday, July 10, 2018
The NIH community and cancer scientists around the world were saddened to learn that Alan Rabson, M.D., a prominent former IRP researcher and Deputy Director of the NIH’s National Cancer Institute (NCI), passed away on July 4 at the age of 92.
Dr. Rabson first joined the NIH in 1955 as a pathologic anatomy resident in the NIH Clinical Center, which had opened just two years before, and he began studying cancer-causing viruses in an NCI intramural laboratory a year later. Over the course of his ensuing six decades with NIH, Dr. Rabson accumulated a great many stories, a few of which we have shared in his own words, pulled from a 1997 “NCI Oral History Project” interview.
By Michael Gottesman
Tuesday, March 7, 2017
Alexis Shelokov, who studied the polio virus at the NIH in the 1950s and was a powerful scientific force in what would become the famed NIAID Laboratory of Infectious Diseases in Building 7, died on December 12, 2016, in Dallas, Texas. He had a prolific scientific career that took him around the world.
