First-Trimester Blood Analysis Could Enable Earlier, More Effective Intervention
Tuesday, October 20, 2020
Imagine a world in which pregnant women routinely travel to places of healing and meet with wise sages who examine a bit of their blood to divine when their babies will be born. While this may sound like something out of Greek mythology, it may soon become a reality, as IRP researchers have developed a test that was able to use blood samples taken early in pregnancy to identify women who would later deliver their babies prematurely.
Mouse Study Suggests Common Fungus Could Worsen Respiratory Infections
Tuesday, September 29, 2020
Throughout the COVID-19 pandemic, both scientists and the media have focused on the factors that influence who experiences mild symptoms or none at all and who faces potentially life-threatening consequences from the disease. Other respiratory viruses like the flu also have widely varying effects on different patients. New IRP research has found that exposure to a common variety of mold primes the immune system to overreact to the flu virus, dramatically increasing the illness’s severity.
Mouse Study Identifies Neurological Obstacle to Dietary Improvements
Tuesday, September 15, 2020
Every morning, thousands of Americans wake up intending to eat more healthfully, only to find themselves chowing down on a greasy burger at dinnertime. In addition to the many biological and socioeconomic obstacles to healthy eating, a salad can just plain seem unappealing compared to a plate of crispy fries. According to new IRP research, a high-fat diet can dramatically alter how the brain responds to food in ways that make a more wholesome meal less enticing and satisfying.
Study Also Reveals Immunotherapy’s Target on Cancer Cells
Tuesday, August 25, 2020
In the 1995 film The Usual Suspects, Kevin Spacey’s con man character famously remarks, “The greatest trick the Devil ever pulled was convincing the world he didn't exist.” The same could be said of cancer, which somehow persuades the body it is not a threat. Cutting-edge treatments called immunotherapies remove this façade and encourage the immune system to attack cancer cells. New IRP research in mice has demonstrated the promise of a new immunotherapy for treating ovarian cancer and identified a marker on cancer cells that could help clinicians identify patients who are most likely to benefit from the therapy.
Experimental Treatment Curbs Autoimmune Eye Disease in Mice
Tuesday, August 11, 2020
Our cells produce a wide range of chemicals necessary for good health, but when they cannot manufacture enough of these substances, scientists can use cells cultivated in their labs to pick up the slack. In a promising example of this approach, IRP scientists stimulated lab-grown immune cells to produce tiny bundles of an important anti-inflammatory molecule and used those packages to successfully treat a potentially blinding autoimmune disease in mice.
High-Tech Nicotine Delivery Technologies Raise Risk for Relapse
Tuesday, July 28, 2020
Scholars have long debated about the use of nuclear power, gene editing, and many other technologies that can have both positive and negative effects on society. Recently, researchers have been having similar discussions about the public health effects of electronic cigarettes. Adding to this debate, a new NIH study highlights a concerning drawback of e-cigarettes by showing they increase the risk that people who have successfully quit smoking will resume using tobacco products.
Mouse Study Illuminates Potential Mechanism Behind Mood and Anxiety Disorders
Tuesday, July 14, 2020
Millions of Americans suffered from depression and anxiety even before COVID-19 began upending their lives. To make matters worse, the stresses of living through a pandemic might not only worsen mental health but could also wreak havoc on the brain itself. New IRP research has found that psychological stress damages blood vessels in the brains of mice and dramatically alters the behavior of genes in certain blood vessel cells.
IRP Study Examines Overlooked Contributor to Racial Health Disparities
Tuesday, June 23, 2020
Recent news coverage of the deaths of George Floyd, Ahmaud Arbery, and Breonna Taylor, along with statistics reporting startlingly disproportionate death rates among black Americans infected with COVID-19, have made it clear that racial biases can be a matter of life and death. Meanwhile, it can be easy to overlook other, more subtle ways that discrimination can affect health, such as new IRP research that links instances of discrimination to poor sleep.
Mouse Study Supports Potential of Ketone-Elevating Treatment
Tuesday, June 2, 2020
Whether from candy, soda, or fruit, sugar is the preferred source of sustenance for many people, and also for their brains. However, in patients with Alzheimer's disease, brain cells are less capable of turning sugar into energy. New IRP research provides evidence that this problem and the cognitive symptoms it causes could be partially solved by providing the brain with an alternative fuel.
Scientists Parse Wide-Ranging Effects of Endometrial Cancer Mutation
Tuesday, May 12, 2020
The so-called ‘butterfly effect’ supposes that a butterfly flapping its wings in Brazil can cause a tornado in Texas. While the jury is still out on insect-induced natural disasters, it is clear that a single genetic mutation can have wide-ranging and unexpected consequences throughout a cell. By examining the ripple effects caused by changes in a particular gene, IRP researchers have identified a potential treatment target for a particularly deadly variety of cancer.