IRP Research Identifies Genetic Risk Factors for Highly Lethal Disease
Tuesday, June 29, 2021
We may share our food and even our beds with them, but despite what many dog lovers might like to believe, our canine companions are not humans who just happen to walk on four legs. One thing we do have in common, though, is the array of genetic diseases that afflict both man and man’s best friend. As a result, scientists can learn a great deal about human illnesses by studying dogs. Using this approach, IRP researchers recently discovered genetic variants that likely play an important role in a rare and poorly understood form of cancer.
Human and Animal Studies Point to New Treatment Strategy
Tuesday, June 8, 2021
Interest in the low-carb ‘ketogenetic’ diet has exploded in recent years, with legions of enthusiasts jumping on the bandwagon. The popular dietary regimen has even caught the attention of scientists seeking new treatments for an array of health conditions. For instance, a recent IRP study suggests that a ketogenic diet might make it easier for people with alcohol use disorder to stop drinking.
Study in Mice Suggests a New Approach to Treating Periodontal Disease
Tuesday, May 18, 2021
Our teeth are extremely tough, but neglectful oral hygiene practices and certain genetic disorders can still massively damage them. If this deterioration becomes bad enough, teeth can be permanently lost. In a recent study, IRP researchers identified a promising new strategy for helping the body regenerate a part of the tooth that is particularly difficult to repair.
Findings Point to Approaches for Staving Off Health Problems in Infected Individuals
Tuesday, April 27, 2021
Over the four decades since it mysteriously began destroying the immune systems of Americans in New York and California, HIV has proven to be a frustratingly wily opponent for scientists. Even today, when treatments can fully suppress the virus in infected individuals, it continues to harm their health. A new IRP study has identified several ways dormant HIV might chronically stimulate the immune system, suggesting potential avenues for preventing the health problems that causes.
New Approach Could Enhance Existing Treatments for Debilitating Genetic Disease
Tuesday, April 6, 2021
The prospect of editing our DNA to treat genetic diseases may have captured the imaginations of scientists and the public in recent years, but that doesn’t mean there aren’t other ways of combating these illnesses. Many promising therapies act not on DNA itself but rather on DNA’s often overlooked cousin, RNA. For instance, experiments in cells performed by IRP researchers have shown promising results or a RNA-targeting therapeutic developed to treat the debilitating genetic disease spinal muscular atrophy.
Unconventional Genetic Strategy Could Enhance Production of Medical Treatments
Tuesday, March 23, 2021
We all have bad days on the job — your colleague keeps bugging you, your boss yelled at you for an innocent mistake, and you skipped lunch because you have 10 different deadlines coming up. Understandably, many people find it much harder to get their work done under such stressful circumstances. Microbes that produce chemicals for medicine and scientific research experience similar struggles, but a recent IRP study has found that short-circuiting their stress response makes them far more efficient at that task.
Biomarker Discovery Could Aid Diagnosis and Therapeutic Development
Tuesday, February 16, 2021
Our cells can’t afford to be wasteful, so they prefer to recycle broken components. However, when the mitochondria that provide their energy are damaged beyond repair, cells may have no choice but to throw them out. New IRP research suggests that more of this mitochondrial debris floats in the blood of patients with Alzheimer’s disease, potentially providing an easy, cost-effective way to diagnose or even possibly predict the illness.
IRP Study Examines Less Time-Intensive Method for Improving Mental Health
Tuesday, January 5, 2021
While working in healthcare can be extremely rewarding, it is also undoubtedly stressful. In particular, the COVID-19 pandemic has had severe repercussions on the mental health of medical professionals, as doctors and nurses struggle to care for unprecedented numbers of sick patients. Fortunately, new NIH research suggests that a relatively brief workplace mindfulness program can reduce stress and anxiety in healthcare workers.
IRP Research Overturns Common Concerns About ‘Weight Cycling’
Tuesday, December 8, 2020
With 2021 less than a month away, many of the more than 200 million Americans who are overweight or obese are beginning to consider making weight loss their New Year’s resolutions — perhaps not for the first time. While trying to lose weight only to ultimately regain it may be disappointing, a new IRP study suggests that repeated attempts at weight loss significantly reduce a person’s risk of dying.
Inhibiting Energy Production Pathway Delays Tumor Formation in Mice
Tuesday, November 10, 2020
Despite the common misconception that sugary treats send kids bouncing off the walls, fat actually provides more than twice as much energy as sugar and other carbohydrates. This energy can be a double-edged sword, fueling not just healthy cells but also cancerous ones. A new IRP study in mice suggests that reducing the body’s ability to burn fat molecules for energy could slow the formation of tumors, potentially extending the lives of individuals with strong genetic predispositions to cancer.