Tuesday, January 8, 2019
For Americans and others living outside the tropics, a mosquito bite is nothing more than an itchy inconvenience, but for billions of others, it can lead to a life-or-death battle with malaria. In some cases, the illness can wreak havoc on the brain. A new IRP study has used magnetic resonance imaging (MRI) technology to demonstrate that an investigational therapy can reverse that damage in mice.
Tuesday, December 11, 2018
The more scientists have learned about the community of benign bacteria inside our bodies, known as the microbiome, the more effort they have put into recruiting it in the fight against disease. What’s more, scientists occasionally discover that treatments long thought to work completely independently of our native microbes also relieve symptoms by interacting with them. New IRP research into the most commonly used medication for type 2 diabetes has led to just such a revelation by demonstrating that its benefits stem in part from its ability to kill off a particular species of bacteria in the human digestive tract.
Tuesday, November 13, 2018
The three-quarters of Americans who own a smartphone use them not just for communicating but also keeping a calendar, playing games, scouring the Internet for funny cat memes, and — soon — maybe even evaluating their neurological health. A new study conducted by IRP and University of Maryland researchers has confirmed the potential of smartphone apps for gauging symptoms of the neurological disease multiple sclerosis.
Tuesday, October 30, 2018
Every good gardener knows the importance of fertilizing the soil before planting seeds, and evidence is accumulating that a similar concept applies to the human body when it comes to experimental stem cell therapies. A new IRP study has uncovered how a medical technology called pulsed-focused ultrasound boosts the healing potency of a particular stem cell treatment.
Tuesday, October 16, 2018
The recent spate of state laws legalizing marijuana for medical or recreational purposes has prompted concerns that increased marijuana use will boost the number of people who become dependent on and abuse the drug, a condition known as cannabis use disorder (CUD). Treating the growing number of patients with CUD will require a greater understanding of how chronic marijuana use can lead to addiction. New IRP research has revealed that star-shaped brain cells called astrocytes may play a role in the pleasurable effects of marijuana and contribute to the drug’s addictive properties.
Tuesday, September 25, 2018
The Human Genome Project gave scientists an incredible roadmap of the thousands of genes used to construct the human body. However, many individuals harbor DNA that differs markedly from the standard reference sequence produced by that initiative, and these variations can have profound implications for a person’s health. A recent study led by IRP scientists has uncovered yet another of these genetic variants, a rare mutation that causes the eye disease retinitis pigmentosa.
Tuesday, September 11, 2018
Between fast-food outlets, vending machines, and food trucks — not to mention good old-fashioned home cooking — many people face no shortage of opportunities to eat. But as satisfying as a crisp potato chip or a moist pork chop may be, people with asthma and many other conditions may prefer to resist tasty temptations if it means alleviating some of their symptoms. In a small pilot study, IRP researchers found evidence that abstaining from food for 24 hours could inhibit some of the cellular processes that cause asthmatics’ breathing problems.
Tuesday, August 28, 2018
Much of the time, new therapies are built from the ground up, with researchers closely scrutinizing a specific molecule or cellular process and designing compounds that can influence it. In some cases, however, scientists take the opposite approach, throwing a multitude of therapeutic darts at the disease dartboard to see what sticks, and then working backwards to unravel why a drug was effective. IRP researchers recently used this method to identify potential treatments for drug-resistant ovarian cancer and determine how some of those tumors become impervious to a particular chemotherapy.
Tuesday, August 14, 2018
As an impatient eater, I find myself burning or biting the inside of my mouth more often than I’d like. Fortunately, these injuries tend to heal within a day or two, whereas wounds like nicking my finger with a knife or scraping my knee seem to take a week or longer to disappear. My personal impressions have now been confirmed by a new NIH study that uncovered major differences in the way the mouth and skin repair themselves, pointing to potential therapeutic targets that could speed healing.
Tuesday, July 31, 2018
While many people can easily stop after a beer or two, for others one drink begets many more, ultimately leading to an addiction that drives continuously increasing alcohol consumption over time. New IRP research has identified a specific type of neuronal receptor involved in the development of alcohol dependence in mice, suggesting a possible approach to curbing problematic drinking behaviors in humans addicted to alcohol.