IRP Discoveries

Pandemic Brings All Hands on Deck

IRP Investigators Begin Hundreds of New Coronavirus-Related Studies

coronavirus particles (gold) emerging from an infected cell

Within just a few months after COVID-19 began spreading in the United States, IRP researchers had already made numerous important contributions to the fight against the deadly virus. Scientific knowledge about the disease continues to expand at a unprecedented pace, and the IRP will continue to play a major role in this effort over the coming months and years. In fact, nearly 300 new intramural research projects related to the novel coronavirus are currently starting up or have already begun.

Dietary Supplement Powers Alzheimer’s-Afflicted Neurons

Mouse Study Supports Potential of Ketone-Elevating Treatment

fuel gauge showing empty

Whether from candy, soda, or fruit, sugar is the preferred source of sustenance for many people, and also for their brains. However, in patients with Alzheimer's disease, brain cells are less capable of turning sugar into energy. New IRP research provides evidence that this problem and the cognitive symptoms it causes could be partially solved by providing the brain with an alternative fuel.

A Long Tradition of Vaccine Breakthroughs

IRP Vaccine Research Stretches Back to the NIH’s Birth

Dr. Meyer (left) and Dr. Parkman (right), along with fellow NIAID scientist Hope Hopps, inspect a culture of the virus that causes rubella

Over the past few months, the world has gained a new appreciation for the long, difficult process of producing vaccines as it waits anxiously for one that will provide protection from the novel coronavirus. With the NIH Vaccine Research Center’s efforts to develop a COVID19 vaccine drawing a huge amount of media attention, it is easy to forget that the IRP has been making vital contributions to vaccine development for more than 100 years. These efforts have helped produce vaccinations for smallpox, rubella, hepatitis A, whooping cough, human papillomavirus (HPV), and several other diseases. Read on for a visual journey through the history of IRP vaccine research. 

Gene Editing Reveals Potential Cancer Treatment Target

Scientists Parse Wide-Ranging Effects of Endometrial Cancer Mutation

a piece of DNA being removed from a DNA molecule

The so-called ‘butterfly effect’ supposes that a butterfly flapping its wings in Brazil can cause a tornado in Texas. While the jury is still out on insect-induced natural disasters, it is clear that a single genetic mutation can have wide-ranging and unexpected consequences throughout a cell. By examining the ripple effects caused by changes in a particular gene, IRP researchers have identified a potential treatment target for a particularly deadly variety of cancer.

Cellular Therapy Could Soothe Sarcoidosis

Cells From Bone Marrow Calm Damaging Immune Response

cells

In patients with the inflammatory disease sarcoidosis, the body’s own immune cells rampage around the body like The Incredible Hulk set loose in a city, attacking both harmful pathogens and our own tissues. However, just like the Black Widow can calm The Hulk down and return him to human form in the Avengers films, cells isolated from our bone marrow may be able to change certain immune cells from a damaging state to a benign one, according to new IRP research.

IRP Researchers Tackle Coronavirus Crisis

New Studies Will Help Efforts to Contain and Treat COVID-19

coronavirus in a patient sample

Most of the time, science is a slow process, with many experiments taking years to yield results. However, as endeavors like the Manhattan Project have shown, scientists can dramatically accelerate the pace of discovery when necessary. Over the past few months, the novel coronavirus pandemic has spurred a burst of research from scientists around the world, including numerous IRP studies. Read on for a round-up of the latest IRP COVID-19 research and learn how IRP investigators are assisting in the fight against the novel coronavirus.

Cellular Self-Destruct Tied to Type 2 Diabetes

Study Suggests New Treatment Strategy for Increasingly Common Disease

a cell undergoing apoptosis

In the classic sci-fi film Alien, the protagonist attempts to destroy the titular monster by triggering the self-destruct mechanism on her spaceship. Our cells also sometimes need to destroy themselves in order to circumvent threats like cancer, but uncontrolled cell death can lead to disease. New IRP research suggests that preventing certain cells in the pancreas from tripping their self-destruct switch could help relieve the symptoms of type 2 diabetes.

Statins May Guard Hearing from Deafening Cancer Chemotherapy

Mouse Study Suggests Approach to Protect Cancer Patients’ Hearing

ear

The internet is filled with lists of ‘life hacks’ that provide instructions on how to re-purpose common items, from turning glass jars into flower vases to using sticky notes to remove dust or crumbs from the crevices of a computer keyboard. On occasion, this kind of inventive spirit can be used to improve human health as well. IRP researchers have found evidence in mice that a statin medication originally created to lower cholesterol might also reduce hearing loss caused by a common cancer therapy.

Teaching an Old Vaccine New Tricks to Thwart Tuberculosis

The IRP’s Mario Roederer and Robert Seder Discuss the Science Behind the Headlines

Mycobacterium tuberculosis bacteria, the cause of tuberculosis

Some say that if something’s not broken, then don’t fix it, but that doesn’t mean there’s no room for improvement. At least, those were the thoughts of IRP senior investigators Mario Roederer, Ph.D., and Robert Alan Seder, M.D., who recently found that the century-old tuberculosis (TB) vaccine is far more effective when administered via injection into a vein (IV) rather than into the skin, which has long been the standard way it is given. This major breakthrough received extensive media coverage, including a story in the New York Times. We went Behind the Headlines to get the inside scoop on this potentially life-saving discovery.

Mouth Microbes Turn Treasonous in Gum Disease

Four Questions with Dr. Niki Moutsopoulos

bacteria

Our mouths are teeming with bacteria, a microbial ecosystem known as the oral microbiome. While these microbes are typically benign, under certain circumstances they can turn harmful and contribute to oral diseases such as periodontitis, a form of chronic gum disease characterized by microbe-driven inflammation of the soft tissues and bone that support our teeth. According to the Centers for Disease Control and Prevention (CDC), roughly 65 million Americans aged 30 or older have some degree of periodontitis. In its early stage, known as gingivitis, the gums become swollen and red due to inflammation, which is the body’s natural response to the presence of bacteria. If the condition worsens, it can lead to loose teeth and, eventually, bone or tooth loss.

NIH senior investigator Niki Moutsopoulos, Ph.D., head of the Oral Immunity and Inflammation Section at the National Institute of Dental and Craniofacial Research (NIDCR), studies periodontitis and aims to understand the immune system’s role in driving this destruction. In a 2018 study, she and her team of IRP researchers and outside collaborators discovered that an abnormal and unhealthy population of microbes in the mouth causes specialized immune cells, known as T helper 17 (Th17) cells, to trigger inflammation and destroy tissue, leading to periodontitis.