neuroscience

Suppressing Neurons Curbs Withdrawal-Induced Pain Hypersensitivity

Insights From Mouse Study Could Aid Treatment for Opioid Use Disorder

man with neck pain

A headache or stubbed toe is annoying enough as it is, but for people in recovery from opioid use disorder, everyday aches and pains — and even sensations that would ordinarily not be painful at all — can be amped up to the point that they become quite distressing. A new IRP mouse study has helped scientists home in on the specific brain cells that might cause this phenomenon, providing a first step towards an intervention that could make it easier for people to stop using addictive opioid medications or illegal drugs like heroin.

Experimental Treatment Helps Neurons Recover From Damage

Mouse Study Could Lead to New Therapies for a Variety of Ailments

neurons firing

In most parts of your brain, the set of neurons you’re born with is what you’ve got for life — just like your fingers and toes, if you lose any, they’re not coming back. The body does have ways to encourage healing after a brain injury, but they are extremely constrained. However, by lending those natural systems a helping hand, IRP researchers have managed to dramatically boost regeneration and recovery of vision in mice with damage to the nerves that connect the eyes to the brain, an approach that could one day help people recover from other types of nervous system injuries as well.

Dialing Down the Brain’s Pain Thermostat

IRP Researchers Discover Center for Pain Control in the Brain

a thermostat inside somebody's head

While pain may be a sensation created by the brain, that doesn’t mean it’s all in your head. New research is showing how a delicate interplay between opposing types of neurons deep within the brain dials pain sensations up and down in response to injuries and other experiences.

September is Pain Awareness Month, a time to recognize that pain is a fact of life. However, while short-term pain is a critical warning system that keeps us from touching hot stoves and prompts us to visit the doctor for necessary medical care, the chronic pain experienced by nearly 100 million Americans often serves no protective purpose. To add insult to injury, this constant and often debilitating pain can evade both explanation and effective treatment.

Scouting Out Summer Poster Day

Annual Event Held In-Person for First Time in Four Years

Amia Black poses with her poster at Summer Poster Day

A few weeks ago, NIH’s Natcher Conference Center bustled with the youthful scientific enthusiasm of IRP summer interns for the first time since 2019, the last time that the IRP’s Summer Poster Day was held in-person. At this year’s event, held on August 3 and 4, the hundreds of high school and college students who conducted research in IRP labs as part of NIH’s Summer Internship Program this year eagerly showed off the fruits of their labors — from discoveries about how weight loss drugs affect the brain to new insights into a potential treatment target for age-related vision loss. Read on to learn more about a few of these scientific upstarts and the research revelations they’ve helped uncover.

Research Reveals Trigger for Brain’s Repairmen

IRP Discoveries Could Enhance Recovery from Brain Injuries

people with repair tools working on a person's head

Many futurists and science fiction writers dream about a time when nanobots will run around our bodies fixing any damage that occurs. Until that day comes, we’re reliant on our immune system to mop up when things go wrong, a fickle set of cells that sometimes needs a push to get going. IRP scientists recently discovered how a particular type of cell in the blood stimulates the brain’s construction crew to leap into action, potentially opening the door to treatments that boost healing in the brain.

Out of the Clinic and Into the Lab

Visiting Medical Students Look Back on IRP Research Experience

Alex Valenzuela

When patients are affected by complex and poorly understood medical problems, it can only be an advantage when their doctors have one foot in the exam room and another in a laboratory studying the disease. However, physicians don’t accrue scientific skills on their own. Rather, they often must venture outside of their medical education to gain experience in research via programs like NIH’s Medical Research Scholars Program (MRSP).

The MRSP allows medical students from across the United States to spend a year working in IRP labs alongside seasoned scientists. The 50 medical students and one dental student selected as 2022 Medical Research Scholars recently finished their time at NIH after arriving on campus last July. Between classes, clinical rounds, study sessions, and exams, five of those young men and women found the time to describe their experience at NIH to the “I Am Intramural” blog, so read on to get a taste of what the MRSP has to offer our nation’s aspiring physicians.

New Neurons Push Away PTSD

IRP Researchers Explore How the Brain Shrugs Off Severe Stress

military man in therapy session

Deep within the brain, a structure called the hippocampus serves as a hub where memory and emotion collide, helping us to learn what not to do if we want to stay safe. However, for the 12 million people in the U.S. with post-traumatic stress disorder (PTSD), those self-preservation instincts kick into overdrive, with severe consequences for quality of life.

June is PTSD Awareness Month, which draws attention to an often-debilitating condition that occurs when people who have experienced or witnessed a traumatic event or period in their lives continue to experience severe depression and anxiety for months or years afterward. While there are a variety of medications and therapies that can help people with PTSD, not everyone benefits from those treatments. Before scientists can develop additional treatment options, they must learn more about the biological roots of the condition, so IRP senior investigator Heather Cameron, Ph.D., is doing her part by examining how stress affects the hippocampus, one of the few brain regions where new neurons are continuously born.

Data Mining for Dementia Clues

IRP Research Examines Under-Appreciated Factors in Alzheimer’s Disease

brain with red area in the middle representing inflammation

This June, the observance of Alzheimer’s and Brain Awareness month reminds us just how devastating the impact of Alzheimer’s and other dementias is across the world. About 55 million people are currently living with Alzheimer’s disease or related dementias such as frontotemporal dementia and Lewy body dementia. This includes the estimated 6.7 million people in the U.S. over age 65 with Alzheimer’s disease, a population whose cognitive decline imposes huge financial costs on the American economy and often unrecognized burdens on the unpaid family members who provide care for those patients.

While the disease has been a target of intensive investigation ever since Alois Alzheimer first discovered clumps of amyloid beta protein and tangles of tau in the brain of a deceased patient in 1906, scientists have made only modest progress in treating it. Efforts to design drugs targeting the abnormal globs of amyloid and tau thought to cause Alzheimer’s have met with only limited success. That’s why IRP investigator Keenan Walker, Ph.D., is taking a different approach: exploring the link between dementia risk and the immune system.

Postbac Poster Day Returns to NIH Campus

Budding Scientists Assemble for First Time Since 2019

IRP postbac fellow Vernon Kennedy with his poster at Postbac Poster Day

In many ways, working at NIH feels like being at a world-renowned university, complete with a variety of classes, intellectually stimulating lectures, social events, and opportunities for professional development. It’s no wonder, then, that NIH has long been a destination for young people who have just departed from their alma maters with their newly earned undergraduate degrees.

These new graduates come to the IRP to hone their scientific skills in NIH’s Postbac IRTA program, conducting research in IRP labs for one or two years under the expert guidance of the IRP’s seasoned investigators. The program also provides the opportunity once per year for participants to present the fruits of their efforts to all their IRP colleagues at Postbac Poster Day, and this year’s event on April 19 and 20 was the first to include an in-person component since 2019. Read on to learn about a few of the nearly 1,000 postbacs who showed off their research at this year’s event, which spanned fields from neuroscience and cancer to genetics and virtual reality.

Symposium Celebrates Award-Winning Female Scientists

Three Young Women Honored at Annual Event

Dr. Brittany Lord

There’s no doubt that science flourishes when it welcomes individuals with different backgrounds and perspectives. In pursuit of that goal, NIH has put considerable effort into closing the gender gap in the biomedical sciences, a field in which men significantly outnumber women, especially as the heads of labs and in leadership positions. Those efforts have so far yielded promising progress, with the proportion of women in IRP senior investigator positions increasing from 22 percent at the end of fiscal year 2016 to 27 percent at the end of fiscal year 2022. Over that same time period, women went from comprising 38 percent of IRP tenure-track investigators to 44 percent.

Part of what makes the IRP a welcoming place for female scientists is the NIH Women Scientists Advisors (WSA), a group of IRP scientists elected to represent the interests of women in the IRP. Once per year, the WSA selects a few female postdoctoral fellows or graduate students conducting research at NIH as WSA Scholars. At a symposium on April 13 honoring the achievements of this year’s Scholars, the awardees presented their efforts to learn more about a devastating childhood neurological condition, decrease health disparities in breast cancer, and use stem cells to investigate the roots of a nerve-destroying disorder. Read on to learn more about this year’s WSA Scholars and the important work they’re doing in their IRP labs.