Five Questions with Dr. Nehal Mehta
Thursday, August 29, 2019
Most Americans know someone who has been affected by heart disease. Despite its status as the leading cause of death in the U.S. today, rates of heart disease have actually been steadily falling since they hit their peak in 1968. In fact, between 1970 and 2005, the life expectancy of the average American increased over 70 percent due in part to reductions in heart disease-related deaths.
Research conducted by IRP scientists has played a key role in curbing the heart disease epidemic by helping identify now well-known risk factors for heart disease, such as high blood pressure, obesity, and physical inactivity. However, not all risk factors are so commonly known. A 2017 study by IRP Lasker Clinical Research Scholar Nehal Mehta, M.D., M.S.C.E., revealed that untreated psoriasis — a chronic, relapsing, inflammatory skin disease — is linked to an elevated risk for premature coronary artery disease. Dr. Mehta’s research demonstrated a strong link between psoriasis-induced skin inflammation and and inflammation of the blood vessels, a precursor to heart disease. Through this study, the largest ongoing study of individuals with psoriasis to-date, Dr. Mehta’s team has concluded that controlling psoriasis-associated skin disease could be an important means of reducing cardiac risk in this population.
Discovery Could Improve Therapy for Multiple Autoimmune Diseases
Tuesday, August 20, 2019
Hiding among YouTube’s vast collection of cooking demos and funny cat videos are clips of patients and their advocates designed to raise awareness of specific diseases. It was just such a video that led IRP Senior Investigator Peter Grayson, M.D., M.Sc., to begin studying an extremely rare illness called deficiency of adenosine deaminase 2, or DADA2 for short. The recently published findings of that research could help improve treatment not just for patients with DADA2 but also many more individuals with similar ailments.
New Insights Could Help Reduce Premature Births
Tuesday, May 28, 2019
Any baby born less than 37 weeks after conception is considered premature, but not all premature births have the same root cause. In a new study, IRP researchers have detailed how a particular component of the immune system can trigger premature labor, which could help doctors prevent more preterm births.
Drug Candidate Calms Overzealous Immune Response in the Eye
Tuesday, April 30, 2019
Our immune cells don’t like strangers and attack many organisms and substances that they have never seen before, including harmless ones. In autoimmune diseases, this reaction gets out of hand and our own cells are caught in the crossfire. IRP scientists have found that a new therapeutic compound can curb this sort of autoimmune carnage in the eye.
Discovery Could Lead to New Approaches for Boosting Blood Cell Counts
Tuesday, March 19, 2019
Much of human biology is a black box — scientists know the key players and the end results, but not how those outcomes come about. Consequently, it remains a mystery why some medications help patients. A new IRP study has cracked open the black box to reveal how high levels of an inflammatory molecule inhibit blood cell production in some individuals and why a particular medicine helps reverse this life-threatening condition.
Thursday, February 28, 2019
The NIH’s main campus in Bethesda, Maryland, may have the look and feel of a university campus, but the world-renowned research institution does not grant credentials like an M.D. or Ph.D. Instead, the Graduate Partnerships Program offers graduate students from schools around the world the opportunity to complete research for their Ph.D. dissertations in IRP labs while pursuing advanced degrees from their ‘host’ institutions.
Tuesday, September 11, 2018
Between fast-food outlets, vending machines, and food trucks — not to mention good old-fashioned home cooking — many people face no shortage of opportunities to eat. But as satisfying as a crisp potato chip or a moist pork chop may be, people with asthma and many other conditions may prefer to resist tasty temptations if it means alleviating some of their symptoms. In a small pilot study, IRP researchers found evidence that abstaining from food for 24 hours could inhibit some of the cellular processes that cause asthmatics’ breathing problems.
Tuesday, June 19, 2018
Hundreds of scientific studies have established that obesity often leads to severe health problems and cuts short many lives. Nevertheless, a significant number of obese people remain healthy despite their excess weight. A new IRP study has now identified a possible molecular marker that distinguishes obese but healthy individuals from those whose weight has negatively affected their health.
Tuesday, June 5, 2018
The most important step to solving any problem is to choose the right tool for the job. Just like a heavy fur coat will keep you comfortable in the Arctic but slowly roast you in the Sahara, your immune system’s response can be helpful or harmful depending on the specific invader it’s fighting off. A new IRP study has identified a molecular “switch” that shifts an important type of immune cell between two different approaches to protecting the body.
Monday, June 4, 2018
The NIH Lasker Clinical Research Scholar Program, an initiative to support early-stage clinical researchers, has reached a milestone. First announced in December 2010, the program provides scholars with up to ten years of support: five to seven years as NIH tenure-track investigators, followed by three years additional funding at an extramural research institution, pending review, if they choose to leave the NIH. Our goal was to recruit a few scholars each year and have a “steady state” of 15 to 20 scholars on campus. We indeed are now up to 15 scholars, which meets this goal.