immunology

A Long Tradition of Vaccine Breakthroughs

IRP Vaccine Research Stretches Back to the NIH’s Birth

Dr. Meyer (left) and Dr. Parkman (right), along with fellow NIAID scientist Hope Hopps, inspect a culture of the virus that causes rubella

Over the past few months, the world has gained a new appreciation for the long, difficult process of producing vaccines as it waits anxiously for one that will provide protection from the novel coronavirus. With the NIH Vaccine Research Center’s efforts to develop a COVID19 vaccine drawing a huge amount of media attention, it is easy to forget that the IRP has been making vital contributions to vaccine development for more than 100 years. These efforts have helped produce vaccinations for smallpox, rubella, hepatitis A, whooping cough, human papillomavirus (HPV), and several other diseases. Read on for a visual journey through the history of IRP vaccine research. 

Scientists Pinpoint Traitorous Immune Cells in Lupus

Narrower Research Focus Could Aid Treatment for Autoimmune Diseases

immune cells called neutrophils (purple) attacking bacteria

Police pursuing a dangerous criminal rely on witness descriptions of the suspect’s specific traits — height, weight, hair color, tattoos — to pick out the perpetrator from a vast population of mostly innocent individuals. Scientists can likewise distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.

IRP’s Michael Lenardo Elected to National Academy of Sciences

NIH Researcher Recognized for Enhancing the Molecular Understanding of Immune Responses

Dr. Michael Lenardo

The National Academy of Sciences (NAS), established in 1863, is comprised of the United States’ most distinguished scientific scholars, including nearly 500 Nobel Prize winners. Members of the NAS are elected by their peers and entrusted with the responsibility of providing independent, objective advice on national matters related to science and technology in an effort to advance innovations in the United States.

IRP senior investigator Michael Lenardo, M.D., is one of four IRP researchers elected to the NAS over the past two years. At the NIH, Dr. Lenardo serves as Chief of the Molecular Development of the Immune System Section at the NIH’s National Institute of Allergy and Infectious Diseases (NIAID), where he studies how the cells in the immune system mount protective responses to various pathogens, including viruses and bacteria. A major focus of Dr. Lenardo’s work is the investigation of genetic abnormalities in the immune system, which have the potential to cause life-threatening diseases.

Remembrances: Phil Leder (1934-2020)

Phil Leder at a chalkboard

Our friend and former colleague Phil Leder, among the world's most accomplished molecular geneticists, died on Sunday, February 2, at age 85. His work with Marshall Nirenberg — namely, the famed Nirenberg and Leder experiments starting at the NIH in 1964, which definitively elucidated the triplet nature of the genetic code and culminated in its full deciphering — helped set the stage for the revolution in molecular genetic research that Phil himself would continue to lead for the next three decades.

NIH Research Festival Hosts Postdoc Poster-Palooza

Annual Event Highlights Contributions of IRP Postdoctoral Fellows

Dr. Subhash Verma

At lunchtime last Wednesday, the NIH Clinical Center’s FAES Terrace echoed with the joyful sounds of scientists nourishing their bodies and their brains. While those stopping by the annual NIH Research Festival poster session could be forgiven for making a beeline straight for the food — including the submissions to this year’s Scientific Directors’ baking competition — once their plates were full, they took advantage of the opportunity to satiate their scientific curiosity as well by checking out the dozens of posters on display.

A New Approach to Fighting the Flu

Six Questions With Dr. Matthew Memoli

person receiving a flu shot

We all know flu season as the time of year where people are loading up on hand sanitizer and heading to the doctor for their flu shot. However, many underestimate the severity of the flu. During a typical flu season, five to twenty percent of Americans fall ill, leading to more than 200,000 hospitalizations and 36,000 deaths. Because of this serious threat to the public, the IRP has a long track record of researching vaccines, antivirals, diagnostics, and other resources in an effort to prevent individuals from catching the flu and improve care for those who do.

Remembrances: Mike Beaven (1936-2017)

Mike Beaven

Michael A. Beaven died unexpectedly on Saturday, April 8, 2017, at age 80. Mike was an expert in mast cell biology and beloved friend and colleague of many. He had worked at the NIH since 1962.

In the past seven years during his formal “retirement,” Mike remained incredibly productive, coauthoring more than 20 primary publications as well as a number of reviews; and he continued to perform experimental work as well as being the “go to” scholar in a range of areas.

Six Paths Forward in Biomedical Research

NIH Clinical Center

Last month I moderated our annual retreat with the NIH Scientific Directors, those individuals tasked with leading their Institute or Center (IC)-based intramural research program. We were joined by many of the IC Clinical Directors. And this year we decided to do something a little different: listen to a series of talks about exciting, new IRP research.

10 Questions with NIH Senior Investigator Howard Young

Highly talented scientists underlie the innovative biomedical research conducted at the NIH IRP. I asked one of them, Dr. Howard Young, Senior Investigator at the National Cancer Institute’s (NCI) Frederick, Maryland, campus, about how the environment of opportunity, access to resources, and proximity to cutting-edge science influences his work.

NIH NCI-Frederick Campus