NIH Researcher Recognized for Investigation into Genomic Stability
Monday, June 29, 2020
The National Academy of Medicine (NAM), first established in 1970 by the National Academy of Sciences as the Institute of Medicine (IOM), is comprised of more than 2,000 elected members from around the world who provide scientific and policy guidance on important matters relating to human health. Election to the NAM is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have not only made critical scientific discoveries but have also demonstrated a laudable commitment to public service.
IRP senior investigator Andre Nussenzweig, Ph.D., was one of four IRP researchers recently elected to the NAM. Dr. Nussenzweig leads the Laboratory of Genome Integrity at the National Cancer Institute (NCI), where he studies how cells repair a form of DNA damage called a double strand break (DSB). This type of insult, which severs both strands of the double-stranded DNA molecule, is one of the most dangerous. If not repaired properly, DSBs can kill cells or cause DNA to rearrange in ways that are associated with cancer. Moreover, while DSBs can be caused by chemotherapy drugs and radiation, they can also happen by random chance during the course of normal cellular processes. Intriguingly, not all parts of the DNA molecule are equally susceptible to this form of damage.
Modifying Tumor’s Surroundings Stymies Cancer’s Expansion
Tuesday, December 10, 2019
If you ever tried planting an apple tree in the desert or growing avocados in New England, you would quickly figure out that such plants need a particular environment in order to thrive. Cancerous tumors are no different, and IRP researchers recently found strong evidence that a molecule naturally produced in the body can suppress the growth and spread of a particularly lethal form of breast cancer via both direct effects on the cancer and by altering its surroundings.
Reddit “Ask Me Anything” Commemorates Breast Cancer Awareness Month
Friday, October 11, 2019
Breast cancer touches the lives of millions of Americans every year. In 2019 alone, researchers expect more than 300,000 American women to be diagnosed with breast cancer, along with more than 2,600 men. Roughly one out of every eight American women will develop invasive breast cancer at some point in her lifetime, making it the second most commonly diagnosed cancer in American women.
On October 9, in recognition of National Breast Cancer Awareness Month, the NIH Intramural Research Program (IRP) partnered with the National Cancer Institute (NCI) to host a Reddit “Ask Me Anything” (AMA) with two prominent researchers in the NCI's Women's Malignancies Branch: Stanley Lipkowitz, M.D., Ph.D., and Alexandra Zimmer, M.D. Between Dr. Lipkowitz’s extensive knowledge of the cellular and molecular pathways involved in breast cancer and Dr. Zimmer’s expertise in the development of clinical trials for breast cancer treatments, the pair were able to offer intriguing insights on topics ranging from recent advances in breast cancer treatment to genetic and environmental factors that influence risk for the disease. Read on for some of the most interesting exchanges that took place, or check out the full AMA on Reddit.
Saturday, October 31, 2015
October is National Breast Cancer Awareness month, four weeks out of the year dedicated to bringing visibility and awareness to research in support of one of the most widespread and devastating cancers in existence.