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I am Intramural Blog

Brandon Levy

Brandon Levy is a Health Communications Specialist for the NIH’s Intramural Research Program, where he works to increase the IRP’s public profile and ensure IRP scientists get the recognition they deserve. He particularly enjoys writing about the cutting-edge research performed at NIH but also produces videos and content for social media. Before joining the IRP, he worked as a science writer in NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and as a postbaccalaureate Intramural Research Training Award (IRTA) fellow in NIH’s National Institute of Mental Health (NIMH), spending his days putting people inside giant magnets and sending magnetic waves into their brains to shed light on the mysteries of learning and memory. When he’s not hunched over a computer keyboard, Brandon enjoys singing in his acapella group, reading, honing his skills as an amateur chef, and over-obsessing about college basketball.


Posts By This Author

Cutting Calories Combats Aging Arteries

Tuesday, January 22, 2019

red blood cells traveling through a blood vessel

While many people think staving off aging means drinking seaweed smoothies and swallowing fish oil supplements, the key to extending life increasingly appears to be not putting things in our mouths. In yet another example of the anti-aging powers of eating less — what scientists call caloric restriction — IRP researchers have identified the specific aging-induced cellular and molecular changes in arteries that are curbed by substantially reducing calorie intake.

Experimental Therapy Reverses Neurological Effects of Malaria

Tuesday, January 8, 2019

MRI brain scans of mice with (right) and without (left) cerebral malaria, indicating areas of damage to the blood-brain barrier

For Americans and others living outside the tropics, a mosquito bite is nothing more than an itchy inconvenience, but for billions of others, it can lead to a life-or-death battle with malaria. In some cases, the illness can wreak havoc on the brain. A new IRP study has used magnetic resonance imaging (MRI) technology to demonstrate that an investigational therapy can reverse that damage in mice.

Science by the Numbers: Modeling Complex Biological Processes

Monday, December 17, 2018

computer microchip with binary code

Science is a process of trial and error. Most successful research publications are preceded by at least a few false starts and perhaps weeks or even months of tinkering to get experiments to work. For IRP senior investigator Carson Chow, Ph.D., this process of testing and throwing out one potential solution after another is an essential part of his research, so much so that he may go through thousands of iterations before arriving at one that works. However, rather than test each approach himself, he leverages the IRP’s considerable computing power to considerably accelerate the process of sorting the wheat from the chaff.

Diabetes Drug Helps Patients by Modifying the Microbiome

Tuesday, December 11, 2018

bacteria in the digestive system

The more scientists have learned about the community of benign bacteria inside our bodies, known as the microbiome, the more effort they have put into recruiting it in the fight against disease. What’s more, scientists occasionally discover that treatments long thought to work completely independently of our native microbes also relieve symptoms by interacting with them. New IRP research into the most commonly used medication for type 2 diabetes has led to just such a revelation by demonstrating that its benefits stem in part from its ability to kill off a particular species of bacteria in the human digestive tract.

Three Billion Base Pairs vs. One Powerful Computer

Tuesday, November 27, 2018

a stand of DNA

The human genome comprises roughly three billion base pairs and around 20,000 protein-coding genes, according to recent estimates. That’s a lot of information crammed into the tiny nucleus of a cell, and it doesn’t even include the many genes that do not produce a protein or the fact that most genes come in multiple flavors that vary in different individuals. Add to that the phenomenon of an identical gene being either more or less active in two different people and you can quickly end up with genomic datasets that would overload nearly any computer. Fortunately for IRP senior investigator Daniel Levy, M.D., the NIH IRP has one of the few computer systems in the world that can handle this mountain of information.

Shedding Light on the Deep Darkness of Depression

Thursday, November 15, 2018

Dr. Carlos Zarate with a participant in a neuroimaging study

In 2016, more than one in twenty American adults and one in ten adolescents experienced at least one major depressive episode. For nearly 45,000 of these individuals, their condition was severe enough that it led them to take their own lives. Unfortunately, the medications currently available to treat depression are not always effective and can take up to six weeks to substantially reduce symptoms.

To improve treatment and accelerate symptom relief, IRP senior investigator Carlos Zarate Jr., M.D., is working towards the development of new medications for depression, along with the identification of new drug targets and objective measures called biomarkers that yield information about how a patient is responding to treatment. In recent years, his lab has extensively investigated and assessed the effects of the anesthetic drug ketamine on depression and suicidal thoughts. Many of the patients in his trials have had marked and rapid responses to ketamine, sometimes within a single day or just a couple of hours. 

On Tuesday, November 13, Dr. Zarate participated in a Reddit “Ask Me Anything” (AMA) to answer questions from the public about the way depression is currently treated and the latest efforts to develop cutting-edge therapies for the condition. Read on for some of the most interesting exchanges that took place or check out the full AMA on Reddit.

Smartphone Apps Show Promise for Assessing Multiple Sclerosis Symptoms

Tuesday, November 13, 2018

brain scan of a patient with multiple sclerosis

The three-quarters of Americans who own a smartphone use them not just for communicating but also keeping a calendar, playing games, scouring the Internet for funny cat memes, and — soon — maybe even evaluating their neurological health. A new study conducted by IRP and University of Maryland researchers has confirmed the potential of smartphone apps for gauging symptoms of the neurological disease multiple sclerosis.

Ultrasound-Based Technique Produces Fertile Ground for Therapeutic Stem Cells

Tuesday, October 30, 2018

Mesencyhmal stromal cells (MSCs) releasing a therapeutic molecule called interleukin-10 (green) in a section of kidney tissue

Every good gardener knows the importance of fertilizing the soil before planting seeds, and evidence is accumulating that a similar concept applies to the human body when it comes to experimental stem cell therapies. A new IRP study has uncovered how a medical technology called pulsed-focused ultrasound boosts the healing potency of a particular stem cell treatment.

Star-Shaped Brain Cells May Contribute to Marijuana Addiction

Tuesday, October 16, 2018

astrocytes

The recent spate of state laws legalizing marijuana for medical or recreational purposes has prompted concerns that increased marijuana use will boost the number of people who become dependent on and abuse the drug, a condition known as cannabis use disorder (CUD). Treating the growing number of patients with CUD will require a greater understanding of how chronic marijuana use can lead to addiction. New IRP research has revealed that star-shaped brain cells called astrocytes may play a role in the pleasurable effects of marijuana and contribute to the drug’s addictive properties.

CRISPR Pioneer Jennifer Doudna Headlines NHGRI 25th Anniversary Celebration

Tuesday, October 9, 2018

It seems like every day there is a new story in a prominent news outlet about the revolutionary gene-editing approach known as CRISPR/Cas9. What these reports often fail to mention is all the scientific discoveries that paved the way for that groundbreaking technology, including the key contributions of government scientists working in the Intramural Research Program of NIH’s National Human Genome Research Institute (NHGRI). Last week, the NHGRI IRP celebrated its 25th anniversary with a day-long symposium headlined by a keynote from the co-discoverer of CRISPR/Cas9, University of California, Berkeley professor Dr. Jennifer Doudna.

Dr. Jennifer Doudna
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This page was last updated on Wednesday, March 15, 2023

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