High-Performance MRI with Lower Magnetic Field
NIH Researchers’ Redesigned MRI Holds Promise for Cardiac and Lung Imaging
NIH researchers, along with researchers at Siemens, have developed a high-performance, low-magnetic-field magnetic-resonance imaging (MRI) system that vastly improves the quality of images of the lungs and other internal structures of the human body. The new system is more compatible with interventional devices that could greatly enhance image-guided procedures that diagnose and treat disease, and the system makes medical imaging more affordable and accessible for patients. The low-field MRI system may also be safer for patients with pacemakers or defibrillators, quieter, and easier to maintain and install.
The NIH researchers involved in the study—which appeared on October 1, 2019, in the journal Radiology—were from the National Heart, Lung, and Blood Institute, the Clinical Center, and the National Institute of Neurological Disorders and Stroke. The trend in recent years has been to develop MRI systems with higher magnetic-field strengths to produce clearer images of the brain. But, researchers calculated that using those same state-of-the-art systems—at a modified strength—might offer high-quality imaging of the heart and lungs. They found that metal devices such as interventional cardiology tools that were once at risk of heating with the high-field system were now safe for real-time, image-guided procedures such as heart catherization.
“We continue to explore how MRI can be optimized for diagnostic and therapeutic applications,” said NHLBI Scientific Director Robert Balaban, who is also chief of NHLBI’s Laboratory of Cardiac Energetics. “The system reduces the risk of heating—a major barrier to the use of MRI-guided therapeutic approaches that [has] hampered the imaging field for decades.”
The researchers also found that lung imaging improved and that oxygen itself can be observed in tissue and blood much better at a lower magnetic field, providing a unique view of the distribution of this vital molecule in the body.
“MRI of the lung is notoriously difficult and has been off limits for years because air causes distortion in MRI images,” said NHLBI Staff Scientist Adrienne Campbell-Washburn. “A low-field MRI system equipped with contemporary imaging technology allows us to see the lungs very clearly. Plus, we can use inhaled oxygen as a contrast agent. This lets us study the structure and the function of the lungs much better.”
The researchers modified a commercial MRI system, Siemens Healthcare’s MAGNETOM Aera, which has a magnetic field strength of 1.5 Tesla (T), to operate at 0.55T while keeping the modern hardware and software needed for high-quality images. Researchers first tested the new imaging procedure using objects that mimic human tissues then quickly applied the procedure to healthy volunteers and patients with disease.
“This research helps us to define new strategies that may improve accessibility and affordability of MRI as an imaging modality,” said Arthur Kaindl, head of Magnetic Resonance at Siemens Healthineers. “We believe the high-performance, low-field MRI will have a great impact on clinical care.”
When researchers compared their 0.55T images with images obtained at 1.5T, they saw lung cysts and surrounding tissues in patients with lymphangioleiomyomatosis (LAM) more clearly. LAM, which occurs only in young women, is a rare disease characterized by the proliferation of atypical smooth muscle cells throughout the lungs, pulmonary blood vessels, lymphatics, and pleurae.
The researchers also found that inhaled oxygen could increase the brightness of lung tissue more effectively with the lower magnetic-field strength than with the higher field strength. These results show how useful low-field MRI can be in helping identify problems in the lungs.
Researchers found similar advantages using low-field MRI during heart catheterization, a procedure used to diagnose and treat some heart conditions but which has been hampered by the unavailability of suitable devices for MRI.
The new generation of low-field MRI allows increased flexibility in image acquisition, said Campbell-Washburn, and researchers can apply the technology for new clinical applications that could change how MRI is used in the future.
“We can start thinking about doing more complex procedures under MRI guidance now that we can combine standard devices with good-quality cardiac imaging,” said Campbell-Washburn, who noted that the results are also encouraging for imaging of the brain, spine, and abdomen. Imaging the upper airway with this system, she said, may also offer valuable clinical information for both sleep and speech disorders.(NIH authors: A.E. Campbell-Washburn, R. Ramasawmy, M.C. Restivo, I. Bhattacharya, Burcu Basar, D.A. Herzka, M.S. Hansen, T. Rogers, W.P. Bandettini, D.R. McGuirt, C. Mancini, H. Xue, J.l Moss, A.A. Malayeri, E.C. Jones, A.P. Koretsky, P. Kellman, M.Y. Chen, R.J. Lederman, and R.S. Balaban, Radiology 293:No. 2, 2019; DOI:10.1148/radiol.2019190452)
This page was last updated on Wednesday, March 30, 2022