lupus

A Step Towards Precision Medicine for Lupus

IRP Research Hints at Potential of Genomic Technologies to Predict Patient Outcomes

blood vial and diagram showing DNA methylation markers on DNA molecules

Our genes certainly have a huge influence over our risk for disease, but they don’t operate in a vacuum. Rather, they’re decorated with numerous molecular tags like a bejeweled bracelet, and these ‘epigenetic’ markers affect how genes behave. A recent IRP study revealed differences in certain epigenetic markers that may one day help doctors more effectively treat patients with the autoimmune disease known as lupus.

Exercise Energizes Patients With Autoimmune Disease

IRP Study Points to the Biological Roots of Physical Activity’s Benefits

woman exercising on treadmill

British science fiction writer Arthur C. Clarke once wrote that, “Any sufficiently advanced technology is indistinguishable from magic.” While not exactly a “technology,” exercise has such wide-ranging health benefits that it could understandably be mistaken for magic. Still, scientists persist in investigating precisely why physical activity is so good for us. Recently, a small IRP study showed that exercise training can help reduce the debilitating fatigue that often accompanies the autoimmune disease known as lupus, and also illuminated some of the underlying mechanisms that may lead to those benefits.

Poster Days Spotlight Young Researchers

Budding Scientists Showcase Research at Annual Event

Yasmin Ali

Any scientist who wants to make game-changing discoveries has to start somewhere — even Albert Einstein worked in a patent office before landing his first job in academia. Through its Postbaccalaureate IRTA program, NIH hopes to give aspiring scientists more of a leg up than Einstein had by bringing them into IRP labs after they complete their undergraduate studies.

On April 26, 27, and 28, more than 900 recent college graduates participating in the program presented at this year’s virtual Postbac Poster Days. Read on to learn about a few of these young researchers and their contributions to the groundbreaking work being done at NIH.

Postbac Poster Day Showcases Young Scientific Talent

Scientists-in-Training Impress at Virtual Event

Malcolm Udeozor

Despite the challenges of working during a global pandemic, IRP scientists continue to make groundbreaking discoveries and mentor the next generation of researchers. This includes the hundreds of recent college graduates conducting research in NIH labs through the Postbaccalaureate IRTA program. On April 28, 29, and 30, many of these budding scientists presented the fruits of their efforts at this year’s virtual Postbac Poster Day. Read on to learn about a small sampling of the scientific strides NIH’s postbacs are making.

Scientists Pinpoint Traitorous Immune Cells in Lupus

Narrower Research Focus Could Aid Treatment for Autoimmune Diseases

immune cells called neutrophils (purple) attacking bacteria

Police pursuing a dangerous criminal rely on witness descriptions of the suspect’s specific traits — height, weight, hair color, tattoos — to pick out the perpetrator from a vast population of mostly innocent individuals. Scientists can likewise distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.

Research Symposium Celebrates Graduate Student Science

Event Spotlights Students Completing Their Ph.D. Research in IRP Labs

NIH graduate student John Fenimore

The NIH provides an extraordinarily rich environment for learning and honing the skills needed to pursue a scientific career. It’s no wonder, then, that Ph.D. students from institutions all across the United States and the rest of the world come here to conduct their dissertation research under the mentorship of the IRP’s many renowned investigators.

Nearly 150 of those students presented the fruits of their scientific work at the NIH’s 16th annual Graduate Student Research Symposium on Thursday, February 20. The insights they have produced on topics from cancer to autoimmune disease to environmental contaminants were supremely impressive and will likely contribute to important improvements in medical care in the future. For anyone who missed this exciting event, read on to learn about a few of the many research projects that were on display.

Rare Disease Research Reveals Why Immune Cells Go Wild

Discovery Could Improve Therapy for Multiple Autoimmune Diseases

neutrophil extracellular traps (NETs)

Hiding among YouTube’s vast collection of cooking demos and funny cat videos are clips of patients and their advocates designed to raise awareness of specific diseases. It was just such a video that led IRP Senior Investigator Peter Grayson, M.D., M.Sc., to begin studying an extremely rare illness called deficiency of adenosine deaminase 2, or DADA2 for short. The recently published findings of that research could help improve treatment not just for patients with DADA2 but also many more individuals with similar ailments.

How Asking a Very Basic Research Question Led Us to a Model For At Least 3 Diseases

When I started this project, it was not my objective to develop a model for any specific disease, nor did I even suspect that the ultimate result would be some insight into autoimmune disease. The basic research question I was asking was why there are sequences in the 3’ untranslated region of the interferon-gamma mRNA that are more highly conserved than the coding region of the gene.

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