Inhibiting Energy Production Pathway Delays Tumor Formation in Mice
Tuesday, November 10, 2020
Despite the common misconception that sugary treats send kids bouncing off the walls, fat actually provides more than twice as much energy as sugar and other carbohydrates. This energy can be a double-edged sword, fueling not just healthy cells but also cancerous ones. A new IRP study in mice suggests that reducing the body’s ability to burn fat molecules for energy could slow the formation of tumors, potentially extending the lives of individuals with strong genetic predispositions to cancer.
Future Physician-Scientists Spent a Year in IRP Labs
Monday, September 21, 2020
Many doctors not only treat patients directly, but also make valuable contributions to research that will improve medical care in the future. Each one of these talented ‘physician-scientists’ began his or her research career under the guidance of a more senior scientist. At the NIH, the Medical Research Scholars Program (MRSP) provides just such an experience to promising young medical students from all across the United States.
Program Boosts Initiatives Supporting Researchers Across NIH
Tuesday, September 1, 2020
From Superbowl-winning football teams to comic book cohorts like The Avengers, combining the efforts of multiple talented individuals is a proven strategy for achieving remarkable results. It may come as no surprise, then, that the NIH’s Intramural Research Program (IRP) strongly encourages collaborations that breach the boundaries of its 24 Institutes and Centers. One example of these efforts is the Director’s Challenge Innovation Awards Program, which since 2009 has funded high-impact scientific projects that bring together researchers from across the IRP.
Study Also Reveals Immunotherapy’s Target on Cancer Cells
Tuesday, August 25, 2020
In the 1995 film The Usual Suspects, Kevin Spacey’s con man character famously remarks, “The greatest trick the Devil ever pulled was convincing the world he didn't exist.” The same could be said of cancer, which somehow persuades the body it is not a threat. Cutting-edge treatments called immunotherapies remove this façade and encourage the immune system to attack cancer cells. New IRP research in mice has demonstrated the promise of a new immunotherapy for treating ovarian cancer and identified a marker on cancer cells that could help clinicians identify patients who are most likely to benefit from the therapy.
Thursday, July 16, 2020
Flossie Wong-Staal — a pioneering former NIH scientist, a major figure in the discovery of HIV, and the first to clone that virus — died on July 8, 2020. She was 73 years old.
Flossie arrived at the NIH as a Visiting Fellow in 1973 and began working in the National Cancer Institute (NCI) lab of Robert Gallo, who was on the cusp of a remarkable string of discoveries. Flossie, with her Ph.D. from UCLA in molecular biology, became the ideal complement to Bob Gallo's medical-based scientific intuition, and the two would go on to co-author more than 100 journal articles over the next 20 years.
NIH Researcher Recognized for Investigation into Genomic Stability
Monday, June 29, 2020
The National Academy of Medicine (NAM), first established in 1970 by the National Academy of Sciences as the Institute of Medicine (IOM), is comprised of more than 2,000 elected members from around the world who provide scientific and policy guidance on important matters relating to human health. Election to the NAM is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have not only made critical scientific discoveries but have also demonstrated a laudable commitment to public service.
IRP senior investigator Andre Nussenzweig, Ph.D., was one of four IRP researchers recently elected to the NAM. Dr. Nussenzweig leads the Laboratory of Genome Integrity at the National Cancer Institute (NCI), where he studies how cells repair a form of DNA damage called a double strand break (DSB). This type of insult, which severs both strands of the double-stranded DNA molecule, is one of the most dangerous. If not repaired properly, DSBs can kill cells or cause DNA to rearrange in ways that are associated with cancer. Moreover, while DSBs can be caused by chemotherapy drugs and radiation, they can also happen by random chance during the course of normal cellular processes. Intriguingly, not all parts of the DNA molecule are equally susceptible to this form of damage.
Scientists Parse Wide-Ranging Effects of Endometrial Cancer Mutation
Tuesday, May 12, 2020
The so-called ‘butterfly effect’ supposes that a butterfly flapping its wings in Brazil can cause a tornado in Texas. While the jury is still out on insect-induced natural disasters, it is clear that a single genetic mutation can have wide-ranging and unexpected consequences throughout a cell. By examining the ripple effects caused by changes in a particular gene, IRP researchers have identified a potential treatment target for a particularly deadly variety of cancer.
Mouse Study Suggests Approach to Protect Cancer Patients’ Hearing
Tuesday, March 24, 2020
The internet is filled with lists of ‘life hacks’ that provide instructions on how to re-purpose common items, from turning glass jars into flower vases to using sticky notes to remove dust or crumbs from the crevices of a computer keyboard. On occasion, this kind of inventive spirit can be used to improve human health as well. IRP researchers have found evidence in mice that a statin medication originally created to lower cholesterol might also reduce hearing loss caused by a common cancer therapy.
Event Spotlights Students Completing Their Ph.D. Research in IRP Labs
Tuesday, February 25, 2020
The NIH provides an extraordinarily rich environment for learning and honing the skills needed to pursue a scientific career. It’s no wonder, then, that Ph.D. students from institutions all across the United States and the rest of the world come here to conduct their dissertation research under the mentorship of the IRP’s many renowned investigators.
Nearly 150 of those students presented the fruits of their scientific work at the NIH’s 16th annual Graduate Student Research Symposium on Thursday, February 20. The insights they have produced on topics from cancer to autoimmune disease to environmental contaminants were supremely impressive and will likely contribute to important improvements in medical care in the future. For anyone who missed this exciting event, read on to learn about a few of the many research projects that were on display.
Decreased Energy Production Could Contribute to Cancer-Related Fatigue
Tuesday, February 18, 2020
We all know the feeling of being wiped out after a hard workout or a grueling day at the office — you just want to flop down on the couch and not move, or even think. For many cancer patients, the treatment for their disease can trigger that sort of physical and mental exhaustion for weeks or months. New IRP research has found evidence linking this phenomenon, known as cancer-related fatigue, to a slow-down in cells’ energy-producing mitochondria.