cancer

Decoding Cancer’s Genetic Blueprint

IRP’s Stephen Chanock Elected to National Academy of Medicine

Dr. Stephen Chanock

IRP senior investigator Stephen J. Chanock, M.D., grew up on the NIH campus, spending many weekends hanging around his father’s lab. Robert M. Chanock, M.D., worked at NIH for 50 years, during which he identified the human respiratory syncytial virus and was elected to the National Academy of Medicine (NAM) for his discoveries. Now, following in his dad’s footsteps, the younger Dr. Chanock has been elected to the NAM for his contributions to our understanding of how inherited genetic variation and environmental factors contribute to the risk of developing cancer.

Leveraging AI To Combat Cervical Cancer

IRP Researcher Identifies Precise Disease Biomarkers

doctor holding an electronic tablet

Over the last few decades, advances in cervical cancer screening and prevention have fundamentally changed the approach to dealing with one of the most common forms of cancer in younger women. While doctors have been able to detect cancerous and pre-cancerous cells with a Pap smear since the 1940s, the more recent discovery that the human papillomavirus (HPV) causes more than 90 percent of cervical cancers now affords greater accuracy to regular screening tests. What’s more, IRP researchers truly changed the game by developing a vaccine against HPV, which was approved by the U.S. Food and Drug Administration (FDA) in 2006. 

Still, despite these extremely positive developments, much work remains to be done, as cervical cancer continues to kill about 4,000 American women each year. In honor of World Cervical Cancer Awareness Month this January, we spoke with IRP Senior Investigator Nicolas Wentzensen, M.D., Ph.D., about his efforts to bring that number as close to zero as possible.

Welcoming NIH’s Four Newest Lasker Scholars

IRP Program Boosts Careers of Promising Physician-Scientists

clockwise from top-left: Dr. Lisa McReynolds, Dr. Chris Grunseich, Dr. Samira Sadowski, and Dr. Andrea Lisco

Many scientists have a seemingly single-minded focus on their research, but there are considerable benefits to having one foot in the lab and the other in the clinic. Working with patients gives researchers a daily reminder of the people they are working so hard to help and allows them to investigate the effects of promising but still experimental treatments in willing volunteers. That’s one of the main reasons why the IRP’s Lasker Clinical Research Scholars Program is designed to accelerate the careers of promising early-career physician-scientists. 

This year, four NIH researchers began receiving support from the Lasker program, allowing them to dramatically expand their cutting-edge research. From investigating the roots of muscle-weakening genetic conditions to probing the mysteries of rare, hormone-producing tumors, these individuals will use the leg up provided by the Lasker Program to make new discoveries that could one day improve their patients’ lives. Read on to learn more about the exciting research the latest crop of Lasker Scholars is pursuing.

Sharing Science at the NIH Research Festival

Poster Sessions Showcase IRP Discoveries

IRP postdoctoral fellow Siobhan Lawler

No single event captures the incredible breadth of research going on in the IRP as effectively as the annual NIH Research Festival. In fact, the event is so jam-packed that it typically stretches over multiple days, running this year from September 23-25. The first day of the 2024 Research Festival kicked off with a poster session where scientists from all across NIH showcased the cutting-edge science they have been working on, demonstrating research on subjects like how cooking affects the brain, vaping’s impact on lung health, 3D models for studying pregnancy complications, and much more. Read on to dive deeper into a few of the more than 400 research projects presented at this celebration of IRP science.

Comparing Two Ways to Blast Tumors

IRP Study Is Examining the Long-Term Effects of Treatments for Children With Cancer

cancer cell being destroyed by a high-energy beam

Not long after German physicist Wilhelm Röntgen identified X-rays in 1895, doctors began using them to treat cancer. They soon realized, however, that this new ‘radium’ therapy — the forebearer of modern-day radiation therapy — could also cause cancer. Today, we know that radiation therapy poses much greater risks to children than adults because their cells are dividing more rapidly than those of adults, making the cells more sensitive to radiation. Children also have more years of life ahead of them during which a cancer instigated by their treatment might develop.

IRP’s Giorgio Trinchieri Elected to National Academy of Sciences

IRP Scientist Has Found New Ways to Wield the Immune System Against Cancer

Dr. Giorgio Trinchieri

Over the past twenty or so years, we’ve seen a sea change in many cancer therapies resulting from advances in immunotherapy. Rather than trying to poison cancer cells with chemotherapy or rip apart their DNA with radiation, these treatments help our own bodies attack the disease. As a result, we’ve seen a remarkable reduction in cancer deaths from many types of tumors. 

NIH Distinguished Investigator Giorgio Trinchieri, M.D., has long stood at the forefront of these discoveries. This year, he was elected to the National Academy of Sciences (NAS) for his achievements in identifying the mechanisms regulating the activity of certain classes of immune cells and how the environment around a tumor interacts with the immune system to suppress an immune response to the disease. This includes searching for ways to expand the benefits of immunotherapy to more patients.

IRP’s Marston Linehan Receives HHS Secretary’s Award for Distinguished Service

Honor Recognizes Groundbreaking Advances in Cancer Genetics

Dr. Marston Linehan

As an undergraduate majoring in English, IRP senior investigator W. Marston Linehan, M.D., was fascinated by the complex poetry of 18th-century writer William Blake. But as much as he loved puzzling out the deeper meanings behind literary metaphors and imagery, Dr. Linehan eventually realized he wanted to do work that had more tangible benefits for people. Biology, with its own deep and complex mysteries, fit the bill.

Nearly 40 years later, Dr. Linehan’s pioneering work in the study of genetic forms of kidney cancer has transformed how doctors treat the disease. Over that period, he and his colleagues discovered or co-discovered nine distinct forms of kidney cancer and identified 10 different genes that cause them. These discoveries have provided the basis for targeted therapies and new approaches to treatment and, this year, earned Dr. Linehan the HHS Secretary’s Award for Distinguished Service, the highest honor given by the US government’s Department of Health and Human Services (HHS).

NIH Book Talk Highlights IRP Cancer Research

"A Fatal Inheritance" Author Larry Ingrassia Discusses His New Book

Lawrence Ingrassia at the NIH event

In June 2024, Mr. Lawrence Ingrassia visited NIH to give a talk about his book, A Fatal Inheritance: How a Family Misfortune Revealed a Medical Mystery, which evolved from interviews with current and former IRP researchers, including IRP scientist emeritus Joseph F. Fraumeni, Jr., M.D.

Li-Fraumeni Syndrome (LFS) is an inherited disorder caused by deleterious variants in the TP53 tumor-suppressor gene that lead to very elevated risk of cancers, including sarcomas, brain, breast, and many others. Investigators at NIH have followed families with LFS since the syndrome was first described in 1969 by Dr. Fraumeni and his late collaborator, Dr. Frederick P. Li. Drs. Li and Fraumeni’s seminal discovery was the foundation on which studies of genetic susceptibility to cancer were built.

Software Tool Guides Breast Cancer Care

IRP’s Jinani Jayasekera Hopes to Help Women Make Medical Decisions

doctor using a tablet to access medical software

The women in our lives deserve flowers and thanks on Mother’s Day, but they also deserve attention to their well-being. This past Sunday, May 12, marked the start of Women’s Health Week, a time to reflect on the decisions women make to look after their own health.

For instance, breast cancer treatments are something no woman wants to think about, but every year about 240,000 newly diagnosed women in the U.S. face high-stakes decisions about what medical interventions to pursue. IRP Stadtman investigator Jinani Jayasekera, Ph.D., and her colleagues in the IRP’s Health Equity and Decision Sciences (HEADS) lab develop software-based clinical decision-making tools to help women and their doctors assess and address their health risks when choosing treatments.

Symposium Spotlights Promising Female Scientists

Annual Event Recognizes Three Young Researchers’ Scientific Accomplishments

Dr. Jennifer Zink

For decades, NIH has been working to solve the problems that have long stymied the careers of many young women interested in becoming scientists. As that essential effort continues, it’s important to shine a spotlight on some of the talented female researchers who are contributing to our knowledge of human health and biology right now.

One way the IRP does that is through the annual NIH Women Scientists Advisors (WSA) Scholar Award Symposium, which each year gives three early-career female scientists working in NIH labs the opportunity to present their work to the entire IRP community. At this year’s symposium, which took place April 29, the most recent group to be named WSA Scholars by NIH’s Women Scientists Advisors committee discussed their efforts to probe pollution’s impact on health, improve immunotherapy for cancer, and examine how screen time affects kids. Read on to learn more about their award-winning research.