postdocs

Postdoc Profile: Where the Climate Meets Community Health

Dr. Richard Remigio Studies the Health Repercussions of Changing Environmental Conditions

Dr. Richard Remigio

Summer 2023 started off on an ominous note. On June 7th, New Yorkers woke up to a deep orange skyline over Manhattan and the Statue of Liberty, resembling a scene from a dystopian novel. Air quality indices there reached ‘code maroon,’ warning that being outdoors was dangerous even for healthy people. Americans and Europeans would subsequently endure some of the highest summer temperatures on record, and in August, wildfires devastated the Hawaiian island of Maui.

These and many other recent events have made it clear how much climate change already affects people’s lives. One of the people trying to combat those consequences is Richard Remigio, Ph.D., a postdoctoral fellow at the Occupational and Environmental Epidemiology Branch at the National Cancer Institute (NCI).

Symposium Celebrates Award-Winning Female Scientists

Three Young Women Honored at Annual Event

Dr. Brittany Lord

There’s no doubt that science flourishes when it welcomes individuals with different backgrounds and perspectives. In pursuit of that goal, NIH has put considerable effort into closing the gender gap in the biomedical sciences, a field in which men significantly outnumber women, especially as the heads of labs and in leadership positions. Those efforts have so far yielded promising progress, with the proportion of women in IRP senior investigator positions increasing from 22 percent at the end of fiscal year 2016 to 27 percent at the end of fiscal year 2022. Over that same time period, women went from comprising 38 percent of IRP tenure-track investigators to 44 percent.

Part of what makes the IRP a welcoming place for female scientists is the NIH Women Scientists Advisors (WSA), a group of IRP scientists elected to represent the interests of women in the IRP. Once per year, the WSA selects a few female postdoctoral fellows or graduate students conducting research at NIH as WSA Scholars. At a symposium on April 13 honoring the achievements of this year’s Scholars, the awardees presented their efforts to learn more about a devastating childhood neurological condition, decrease health disparities in breast cancer, and use stem cells to investigate the roots of a nerve-destroying disorder. Read on to learn more about this year’s WSA Scholars and the important work they’re doing in their IRP labs.

Postdoc Profile: Going the Extra Mile

Dr. Ayland Letsinger examines the effects of exercise on the brain

Dr. Ayland Letsinger

Every January, gyms are flooded with new members using the beginning of a new year as a burst of motivation to get fit. When many of these new exercise enthusiasts abandon their new healthy habit within a couple months, they shouldn’t feel guilty, according to IRP postdoctoral fellow Ayland Letsinger, Ph.D. He believes there’s a genetic component behind our fluctuating interest in exercise, and he spends his days in his IRP lab investigating such biological factors behind the motivation to move.

“More people would rather binge-watch 'Stranger Things’ for three hours than do 30 minutes of moderate physical activity, and there may be a biological basis behind it,” he explains.

Postdoc Profile: Eavesdropping On Bacterial Banter

Dr. Tiffany Zarrella Examines Communication Between Bacteria to Combat Persistent Infections

Dr. Tiffany Zarella

Facebook’s nearly 3 billion users may seem like a huge social network, but it pales in comparison to the conversations among the trillions of microbes that live inside a single human body. Few people know this better than IRP postdoctoral fellow Tiffany Zarrella, Ph.D., who spends her days eavesdropping on the messages bacteria send to one another to improve treatment for stubborn infections.

Dr. Zarrella was drawn to the bacterial world in microbiology lab courses while earning a biochemistry degree at Syracuse University in New York. After graduation, she obtained a research technician position at Albany Medical College, where she worked on projects centered around infectious bacteria and how they respond to their environments. She continued this thread of research in graduate school, moving on to a new study to discover how Streptococcus pneumoniae bacteria, which often cause ear infections and pneumonia, use a particular signaling molecule to resist antibiotic treatments and evade vaccines.

Postdoc Profile: From Bench to Bedside and Back Again

Dr. Stefan Barisic Turns Laboratory Discoveries into Kidney Cancer Treatments

Dr. Stefan Barisic

The Laboratory of Transplantation Immunotherapy sits at the heart of the NIH Clinical Center, just down the hallway from the Southeast inpatient unit. Here, IRP postdoctoral research fellow Stefan Barisic, M.D., labors at the bench with the goal of creating practical treatments for kidney cancer patients. Having such proximity to his patients was one of the chief attractions of working at NIH for Dr. Barisic.

“The NIH Clinical Center is an amazing place because it has all the resources you need to go from the bench to the bedside and back to the bench all in one building,” says Dr. Barisic.

Award Honors Promising Female Scientists

Women Scientists Advisors Select Three Young Researchers for Recognition

Dr. Sally Chang

While women have now overtaken men in terms of admission and enrollment in undergraduate education, they remain underrepresented in the sciences. This includes at NIH, where 74 percent of senior investigators and 54 percent of tenure-track investigators are male, according to the most recent statistics available. Consequently, NIH is putting considerable effort into supporting women scientists at all stages of their careers.

One NIH entity dedicated to this important work is the NIH Women Scientists Advisors (WSA), a group of women elected to represent the interests of women scientists in the IRP. Among its many initiatives, each year the WSA chooses several female postdoctoral fellows or graduate students in the IRP to receive the WSA Scholar Award in recognition of their outstanding scientific achievements. The awardees present their research at the annual WSA Scholars Symposium, which this year was held on April 25 and recognized young women leading efforts to better understand how disease-related genes evolved, an investigation of how a fatty liver can give rise to liver cancer, and the evaluation of a way to deliver gene therapy for a rare genetic disease. Read on to learn more about this year’s WSA Scholars and the impressive discoveries they have made during their time in the IRP.

Postdoc Profile: A Bird’s-Eye View of Retinal Disease

Dr. Noor White Traces Evolution to Identify Genes Critical for Vision

Dr. Noor White

The eye has existed in some form for roughly 600 million years. Its many intricate components and the general ability of organisms to sense light have continued to adapt and evolve over huge spans of time into what we know as vision today. By mapping out the evolution of vision, Noor White, Ph.D., hopes to shed light on the genetic causes of diseases that affect the retina, the part of the eye that turns light into electrical signals the brain can use to build an image of our surroundings.

“If we can take a step back and look at the bigger picture, then we can identify the critical genetic components of vision,” explains Dr. White, who was an IRP postdoctoral fellow for four years before becoming a Staff Scientist in March.

Postdoc Profile: Finding the Narrative Behind the Numbers

Dr. Shameka Poetry Thomas Documents Black Women’s Experiences With Race and Racism

Dr. Shameka Poetry Thomas

The numbers are clear: Black women are three to four times more likely to die from pregnancy-related causes than White women in the United States. However, the reasons why are less clear. By listening to patient’s stories, IRP postdoctoral fellow Shameka Thomas, Ph.D. hopes to pinpoint potential explanations for this racial health disparity. 

“We are losing mothers and children because we are simply not listening,” Dr. Thomas says.

Trained as a medical sociologist at the University of Miami, Dr. Thomas has devoted her career to documenting the lived experiences of patients of color, particularly women, who are perceived as Black. Dr. Thomas contextualizes patient’s narratives within a framework of ‘street race,’ which refers to how a person’s racial identity is perceived by others, regardless of their self-reported racial identity. Examining the influence of street race on women’s healthcare experiences, she explains, allows researchers to determine how health disparities are influenced by “how others see you.”

Postdoc Profile: An Engineer Among Epidemiologists

Dr. Shuai Xie Brings a New Perspective to Research on Environmental Exposures

Dr. Shuai Xie

“Engineering is about solving problems,” says IRP postdoctoral fellow Shuai Xie, Ph.D., M.P.H.

Dr. Xie speaks from experience. One of the problems she was interested in solving during her graduate studies in chemical and environmental engineering was how to accurately measure the way airborne contaminants adhere to and release from indoor building materials. This is a particularly important problem to solve because those interactions can affect measurements of indoor air pollution, potentially rendering them inaccurate. Of course, Dr. Xie was not trying to solve this engineering problem for its own sake; accurately gauging contamination of indoor air is important for human health.

Postdoc Profile: COVID-19 Provides New Opportunities for Virus Science

Dr. Alberto D. López-Muñoz Pivots to New Research Focus Amidst Pandemic

Dr. Alberto D. López-Muñoz

Like all virologists, IRP postdoctoral fellow Alberto D. López-Muñoz, Ph.D., knew a global pandemic was sadly inevitable. No one could predict exactly when, but it was just a matter of time until a novel virus would make its way around the globe. Nevertheless, when the COVID-19 pandemic hit, caused by a virus called SARS-CoV-2, even Dr. López-Muñoz was surprised by how rapidly his career transformed as he switched gears study the novel contagion.