IRP Leverages Supercomputing to Combat Coronavirus
Wednesday, August 19, 2020
Over the past six months, a tiny virus has completely upended life in the United States and many other countries. To combat this microscopic threat, some IRP researchers have turned to a tool the size of a small building.
Biowulf, the NIH’s supercomputer, is supporting more than a dozen different IRP research projects focused on the novel coronavirus. As the world’s most powerful supercomputer solely dedicated to biomedical research, Biowulf allows scientists to analyze data and run simulations at unprecedented speed. Two weeks ago, a blog post described how IRP investigators are using Biowulf to elucidate the structure of the novel coronavirus and simulate how potential therapeutics might interact with it. Picking up where that post left off, this blog will explore the application of Biowulf to important questions about the spread of COVID-19 and the way that its genes, along with our own, might influence its impact on the body.
IRP Research Examines Pandemic From All Angles
Tuesday, July 7, 2020
The sheer number of labs and wide variety of scientific perspectives in the IRP make it particularly well-suited to combating a disease like COVID-19, which is affecting patients’ health and the world around them in a huge number of ways. IRP researchers specializing in psychology, genetics, epidemiology, and many other disciplines are pursuing an array of strategies to learn more about the novel coronavirus.
Four Questions with Dr. Cari Kitahara
Thursday, January 23, 2020
As happens with every new year, many people around the world woke up on January 1 committed to improving their health through eating well and exercising. These lifestyle changes have the potential to significantly improve the well-being of the 32 percent of American adults who are overweight and the 40 percent who are obese. Due to the staggering number of individuals struggling with obesity, as well as its serious health consequences, the condition has long been a main priority for researchers at the NIH. As a result of this focus, investigators have made significant strides in identifying biological signals that trigger hunger, understanding genetic influences that play a role in weight gain, and uncovering environmental and behavioral factors that influence obesity.
Understanding Social and Behavioral Research in the IRP
Tuesday, December 3, 2019
The NIH IRP is world-renowned for its high-risk, high-reward biomedical research. While the NIH may be best known for its clinical and biomedical research on topics from cancer to allergies to addiction, IRP investigators have also produced a rich body of work conducted in the area of social and behavioral research (SBR). In this post, I will describe how SBR furthers the NIH’s goals of improving human health with some examples of the excellent work done by SBR investigators in the IRP.
Tuesday, January 29, 2019
Virtually all parents would agree that having kids is a massive undertaking, and not just after they’re born. Many couples struggle to conceive, and each year thousands of American women experience complications when giving birth. With the help of the NIH’s state-of-the-art supercomputer, Biowulf, IRP senior investigator Rajeshwari Sundaram, Ph.D., develops and refines statistical tools that can guide prospective parents and their doctors through these challenges.
Friday, February 9, 2018
At the start of his third term in 1941, President Franklin Delano Roosevelt’s blood pressure was an alarmingly high 188/105—or, more accurately, alarming by today’s standards. But back then, nobody knew that high blood pressure was related in any way to cardiovascular disease (CVD). As a result, the nation was completely blind-sided when Roosevelt died of a stroke four years later.
The link between hypertension and CVD is now common knowledge due to a research program launched in 1948 called the Framingham Heart Study, now in its 70th year. To kick off American Heart Month this February, the Framingham Study’s current director, IRP Senior Investigator Daniel Levy, M.D., gave a lecture on February 1, titled “Unraveling the Mysteries of Cardiovascular Disease: Lessons from NHLBI’s Framingham Heart Study.”
Saturday, October 31, 2015
October is National Breast Cancer Awareness month, four weeks out of the year dedicated to bringing visibility and awareness to research in support of one of the most widespread and devastating cancers in existence.
Monday, March 9, 2015
Jill Koshiol, Ph.D., is an epidemiologist and one of eight Stadtman Investigators who joined the NIH IRP in 2009-2010, the search's inaugural recruitment year. As a tenure-track principal investigator within the National Cancer Institute (NCI) Division of Cancer Epidemiology and Genetics (DCEG), Dr. Koshiol and her team study the epidemiology of infectious agents and cancer, and they are increasingly interested in the role of immune stimulation and inflammation in carcinogenesis.
In the following Q&A, Dr. Koshiol shares some thoughts on how she became a scientist and what's its like to conduct biomedical research at the NIH IRP.
Friday, February 13, 2015
“And he said, ‘I can assure you that if you go through and become a good dentist, people will travel all over the world to find you. Chemists travel all over the world to find a job.”
That was the advice for Dr. Francis Arnold, who did become a dentist and helped establish the National Institute of Dental and Craniofacial Research, from his mentor, Dr. Thomas Hill, Professor of Clinical Oral Pathology and Therapeutics at Western Reserve University. The excerpt, and those that follow, come from Dr. Arnold's 1964 NIH oral history series. During the interviews, he discusses how his experiments and interests led him to become one of the four Public Health Service scientists who pioneered the study of fluorides and their effect on teeth.