Thursday, January 26, 2017
For gene therapy research, the perennial challenge has been devising a reliable way to insert safely a working copy of a gene into relevant cells that can take over for a faulty one. But with the recent discovery of powerful gene editing tools, the landscape of opportunity is starting to change. Instead of threading the needle through the cell membrane with a bulky gene, researchers are starting to design ways to apply these tools in the nucleus—to edit out the disease-causing error in a gene and allow it to work correctly.
Tuesday, November 29, 2016
In a new study of families affected by Attention Deficit Hyperactivity Disorder (ADHD), National Institutes of Health (NIH) Intramural researchers have identified different connections in the brain that children may inherit from their parents and are linked to the disorder.
Thursday, October 13, 2016
Dr. Hong Xu's team’s expertise in mitochondrial DNA genetics, along with a strong mitochondrial biology research group in the IRP, allowed them to solve the fundamental biological question of how organisms are able to stop the accumulation of mitochondrial DNA mutations from being passed on to future generations.
Tuesday, September 20, 2016
Given that Alzheimer’s is such a complex disease with many causes and pathways, it is not surprising that the search for effective treatments has proven difficult. So I spoke with Drs. Yujun Hou and Hyundong Song, postdoctoral fellows in the IRP’s Laboratory of Molecular Gerontology at the National Institute on Aging (NIA) to learn more about their approaches to meeting the challenge.
Tuesday, June 14, 2016
Hi, my name is James. I’ve always really liked science and I want to be a scientist when I grow up, but I never got to see where scientists work until I went to Take Your Child to Work Day at NIH with my Auntie Kit. It was awesome!
Friday, June 10, 2016
Are you beginning to think that slide rules look alike? If you could see the types and number of scales, you’d understand that each slide rule model is different. There are specialized scales for cubes, spheres, voltage, etc. Check out a few of the slide rules that made history with IRP investigators.
Wednesday, July 8, 2015
As an “I Am Intramural” Blog reader, you likely know that the IRP is comprised of more than 6,000 scientists conducting basic, translational, and clinical research in more than 50 buildings on six different IRP campuses around the U.S.But, do you know the answers to the questions in the following IRP Pop Quiz?
Researchers at the NIH IRP have access to:
a) Laboratory equipment sales, rental, repairs, and maintenance
b) Plants and marine organisms for research
c) High-throughput DNA sequencing
d) A and C
e) All of the above
Learn the answer...
Wednesday, May 27, 2015
Most workplaces would never think of having hawks, turtles, beetles and stick bugs at an event for kids—but most workplaces are not the National Institutes of Health. Each year, the NIH Bethesda campus holds its Earth Day celebration in conjunction with Take Your Child to Work Day. Employees share their love of science with their kids while also learning about how to protect the environment.
Monday, April 20, 2015
Ever since the discovery of the double-helix structure of DNA, scientists have sought ways to edit the genome. Altering gene expression partially and transiently via small interfering RNA has come a long way, and the progress has been spectacular. However, achieving complete and sustained modification of gene expression in a cell remains a tedious procedure that is often costly and time-consuming. For molecular biologists working with cell lines, quick and efficient knock out of one or more genes would provide a powerful tool for their studies. The CRISPR technology arrived two years ago to potentially fulfill that need.
Tuesday, February 17, 2015
You mix everything together that’s necessary for the reaction, and half the time it works, half the time it doesn’t. One day you get great PCR results, you’re on cloud nine, everything worked, and then you go repeat it to verify the result (because n never equals 1 in science), and it doesn’t work. You begin to feel like maybe you just got lucky with the first experiment.