Tuesday, September 25, 2018
The Human Genome Project gave scientists an incredible roadmap of the thousands of genes used to construct the human body. However, many individuals harbor DNA that differs markedly from the standard reference sequence produced by that initiative, and these variations can have profound implications for a person’s health. A recent study led by IRP scientists has uncovered yet another of these genetic variants, a rare mutation that causes the eye disease retinitis pigmentosa.
Monday, July 23, 2018
I knew very little about neuroscience before beginning my graduate studies, but the topic of neurodegeneration looked very interesting. Having applied to several labs, I landed a Ph.D. student position in a neuroscience lab at the Saha Institute of Nuclear Physics, a government research institute in India, that would propel me on my way to the NIH IRP. In the first year of my Ph.D. program, I learned several things about the central nervous system (CNS), but what intrigued me the most was its lack of ability to regenerate after injury.
Thursday, April 27, 2017
Studying the neural control of behavior is a challenge. Researchers must consider an animal’s environment, past experiences, and motivations. Work in relatively simple organisms, for example the invertebrate C. elegans, has teased apart the neural circuitry of highly stereotyped behaviors, like foraging. But in mammals, very little is known, “and that’s surprising given just how important behaviors like this are,” said Dr. Eric Horstick, who studies the molecular mechanisms underlying animal behavior.
Tuesday, August 9, 2016
Scientists use a variety of laboratory techniques to investigate the genetic cause of human diseases. While mice and rats have been common choices for modeling human diseases in the past, the use of zebrafish is rapidly gaining popularity. Does this surprise you? Let me explain.