microscopy

Cool Videos: Looking Inside Living Cells

Reblogged via the NIH Director's Blog.

ASCB Celldance 2016 — “Discovery Inside Living Cells in Multicellular Organisms” Roberto Weigert

Roberto Weigert is a cell biologist who specializes in intravital microscopy (IVM), an extremely high-resolution imaging tool that traces its origins to the 19th century. What’s unique about IVM is its phenomenal resolution can be used in living animals, allowing researchers to watch biological processes unfold in organs under real physiological conditions and in real time.

Shared Resources Help IRP Researchers Do Science

Scientists in the NIH Intramural Research Program (IRP) go to work each day in the biomedical equivalent of a candy store. The advanced equipment and shared tools readily available to researchers doing basic, translational, and clinical science in the IRP are unmatched anywhere else, which enables high efficiency and productivity within the IRP’s unique discovery model. Read more...

Technology Incubators and Imaging at NIH Research Festival

Until recently, visualizing many of the processes underlying human diseases had been almost impossible. The NIH IRP’s role in developing technologies that can peer into human organs and cells is a key component of the Long-Term Intramural Research Program Planning Report and basis of sessions during this year’s #ResearchFest.

Exploring the Body’s Microcosmos

Monitoring cell movement. Examining the microenvironment of a tumor. Mapping a gene. Scientists at the NCI Center for Cancer Research (CCR)—the intramural research program at the National Cancer Institute—use a wide variety of microscopy techniques to observe and probe the otherwise invisible processes that drive cancer at the molecular level

Breast cancer cells

Time-Lapse: Students Build Microscope in 4 Minutes

As part of a microscopy course at the National Center For Biological Sciences in Bangalore, India, Dr. Hari Shroff and Dr. Abhishek Kumar of the NIBIB IRP led a team of students in building a dual-view selective plane illumination microscope (diSPIM). It took them about eight hours to complete, but you can view the whole process in just four minutes in the timelapse video below:

The Cave of Wonders: My Life As A Microscopist

As a postdoc in the Membrane Transport Biophysics Unit at NINDS, I’ve spent the past several years studying lysosomal pH. For me, that means spending a lot of my time in a pitch-black room, a room that I refer to as my cave.

U-2 OS lysosomes scale bar