Tuesday, March 27, 2018
Like a bear leaves its ominous footprints in the snow, diseases and other biological processes often leave traces throughout our bodies. Recent technological and scientific advances have enabled clinicians to use measurements of these ‘biomarkers’ in their attempts to improve our health. A new study by IRP researchers revealed that patients with a sleep disorder called obstructive sleep apnea (OSA) have higher blood concentrations of certain biomarkers that may foreshadow poor brain health later in life.1
When people with OSA sleep, their throat muscles relax and block their windpipes, preventing proper breathing and often waking them up. As a result, these individuals get lower-quality sleep and their brains receive less oxygen at night.
“The overall idea is that those two conditions are not good for brain health, but nobody had really looked to see if some of the biomarkers we see in brain injury are also common in younger individuals with this type of disordered breathing,” says IRP Lasker Clinical Research Scholar Jessica Gill, Ph.D., R.N., the study’s senior author.
Monday, March 5, 2018
Carly Kaplan, a junior at Brown University in Providence, Rhode Island, spent her summer working in the lab of NIH IRP Investigator Dr. Kareem Zaghloul. As a member of Dr. Zaghloul’s team, Carly examined how the human brain creates and recalls memories. An aspiring doctor, she believes that this sort of research is “the backbone of the medical profession” and that “doctors can’t do what they do without the research behind it.” While at NIH, she was particularly intrigued by the opportunity to watch Dr. Zaghloul perform neurosurgery on the epilepsy patients who were part of in his lab’s studies.
Thursday, September 29, 2016
What if we could diagnose risk for Alzheimer’s before symptoms appeared? To address the challenge, in the Laboratory of Neurosciences at the IRP, Dr. Maja Mustapic searches for Alzheimer’s biomarkers using liquid biopsies.
Tuesday, September 20, 2016
Given that Alzheimer’s is such a complex disease with many causes and pathways, it is not surprising that the search for effective treatments has proven difficult. So I spoke with Drs. Yujun Hou and Hyundong Song, postdoctoral fellows in the IRP’s Laboratory of Molecular Gerontology at the National Institute on Aging (NIA) to learn more about their approaches to meeting the challenge.
Thursday, June 30, 2016
We all know that exercise is important for a strong and healthy body. Less appreciated is that exercise seems also to be important for a strong and healthy mind, boosting memory and learning, while possibly delaying age-related cognitive decline. How is this so? Researchers have assembled a growing body of evidence that suggests skeletal muscle cells secrete proteins and other factors into the blood during exercise that have a regenerative effect on the brain.
Monday, January 26, 2015
Mitochondria are dynamic cellular organelles involved in ATP synthesis and in apoptotic mechanisms (programmed cell death). However, in addition to these classically known functions, recent studies at the NIH have deciphered another intriguing role for mitochondria in the development and plasticity of neurons.