Kareem Zaghloul, M.D., Ph.D.


Functional and Restorative Neurosurgery Unit


Building 10, Room 3D20
10 Center Drive
Bethesda, MD 20892



Research Topics

​Our lab exploits the unique investigative opportunities provided by intracranial electrical recordings during neurosurgical procedures. Using recordings captured from epilepsy patients implanted with subdural and depth electrodes, we investigate the activation of cortical networks during memory encoding and recall.And using the recordings captured during the implantation of deep brain stimulators, we investigate the role of the basal ganglia in learning and decision making.


Dr. Zaghloul received his B.Sc. degree from MIT in 1995 and his M.D. and Ph.D. degrees from the University of Pennsylvania in 2003. His graduate work focused on developing silicon models of visual processing in the mammalian retina with Dr. Kwabena Boahen. Dr. Zaghloul completed a residency in Neurological Surgery in 2010 from the University of Pennsylvania. During this time, he completed postdoctoral research with Dr. Michael Kahana, investigating the neural correlates of human memory encoding, decision, and reward. Dr. Zaghloul has completed clinical fellowships in Epilepsy Surgery and in DBS Surgery. Dr. Zaghloul joined NINDS as a Staff Clinician in 2010, and as an Investigator in 2013. His laboratory is focused on investigating the neural mechanisms underlying human cognitive function.

Selected Publications

  1. Vaz AP, Inati SK, Brunel N, Zaghloul KA. Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory. Science. 2019;363(6430):975-978.

  2. Wittig JH Jr, Jang AI, Cocjin JB, Inati SK, Zaghloul KA. Attention improves memory by suppressing spiking-neuron activity in the human anterior temporal lobe. Nat Neurosci. 2018;21(6):808-810.

  3. Zavala BA, Jang AI, Zaghloul KA. Human subthalamic nucleus activity during non-motor decision making. Elife. 2017;6.

  4. El-Kalliny MM, Wittig JH Jr, Sheehan TC, Sreekumar V, Inati SK, Zaghloul KA. Changing temporal context in human temporal lobe promotes memory of distinct episodes. Nat Commun. 2019;10(1):203.

  5. Chapeton JI, Haque R, Wittig JH Jr, Inati SK, Zaghloul KA. Large-Scale Communication in the Human Brain Is Rhythmically Modulated through Alpha Coherence. Curr Biol. 2019.

This page was last updated on March 5th, 2015