Kareem Zaghloul, M.D., Ph.D.

Investigator

Functional and Restorative Neurosurgery Unit

NINDS

Building 10, Room 3D20
10 Center Drive
Bethesda, MD 20892

301-594-8114

kareem.zaghloul@nih.gov

Research Topics

‚ÄčOur lab exploits the unique investigative opportunities provided by intracranial electrical recordings during neurosurgical procedures. Using recordings captured from epilepsy patients implanted with subdural and depth electrodes, we investigate the activation of cortical networks during memory encoding and recall.And using the recordings captured during the implantation of deep brain stimulators, we investigate the role of the basal ganglia in learning and decision making.

Biography

Dr. Zaghloul received his B.Sc. degree from MIT in 1995 and his M.D. and Ph.D. degrees from the University of Pennsylvania in 2003. His graduate work focused on developing silicon models of visual processing in the mammalian retina with Dr. Kwabena Boahen. Dr. Zaghloul completed a residency in Neurological Surgery in 2010 from the University of Pennsylvania. During this time, he completed postdoctoral research with Dr. Michael Kahana, investigating the neural correlates of human memory encoding, decision, and reward. Dr. Zaghloul has completed clinical fellowships in Epilepsy Surgery and in DBS Surgery. Dr. Zaghloul joined NINDS as a Staff Clinician in 2010, and as an Investigator in 2013. His laboratory is focused on investigating the neural mechanisms underlying human cognitive function.

Selected Publications

  1. Jang AI, Wittig JH Jr, Inati SK, Zaghloul KA. Human Cortical Neurons in the Anterior Temporal Lobe Reinstate Spiking Activity during Verbal Memory Retrieval. Curr Biol. 2017;27(11):1700-1705.e5.

  2. Chapeton JI, Inati SK, Zaghloul KA. Stable functional networks exhibit consistent timing in the human brain. Brain. 2017;140(3):628-640.

  3. Yaffe RB, Shaikhouni A, Arai J, Inati SK, Zaghloul KA. Cued Memory Retrieval Exhibits Reinstatement of High Gamma Power on a Faster Timescale in the Left Temporal Lobe and Prefrontal Cortex. J Neurosci. 2017;37(17):4472-4480.

  4. Zavala B, Damera S, Dong JW, Lungu C, Brown P, Zaghloul KA. Human Subthalamic Nucleus Theta and Beta Oscillations Entrain Neuronal Firing During Sensorimotor Conflict. Cereb Cortex. 2017;27(1):496-508.

  5. Yaffe RB, Kerr MS, Damera S, Sarma SV, Inati SK, Zaghloul KA. Reinstatement of distributed cortical oscillations occurs with precise spatiotemporal dynamics during successful memory retrieval. Proc Natl Acad Sci U S A. 2014;111(52):18727-32.


This page was last updated on March 5th, 2015