Kareem Zaghloul, M.D., Ph.D.
Functional Neurosurgery Section
Building 10, Room 3D20
10 Center Drive
Bethesda, MD 20814
Our lab exploits the unique investigative opportunities provided by intracranial electrical recordings during neurosurgical procedures. Using recordings captured from epilepsy patients implanted with subdural and depth electrodes, we investigate the activation of cortical networks during memory encoding and recall.And using the recordings captured during the implantation of deep brain stimulators, we investigate the role of the basal ganglia in learning and decision making.
Dr. Zaghloul received his B.Sc. degree from MIT in 1995 and his M.D. and Ph.D. degrees from the University of Pennsylvania in 2003. His graduate work focused on developing silicon models of visual processing in the mammalian retina with Dr. Kwabena Boahen. Dr. Zaghloul completed a residency in Neurological Surgery in 2010 from the University of Pennsylvania. During this time, he completed postdoctoral research with Dr. Michael Kahana, investigating the neural correlates of human memory encoding, decision, and reward. Dr. Zaghloul has completed clinical fellowships in Epilepsy Surgery and in DBS Surgery. Dr. Zaghloul joined NINDS as a Staff Clinician in 2010, and as an Investigator in 2013. His laboratory is focused on investigating the neural mechanisms underlying human cognitive function.
Vaz AP, Wittig JH Jr, Inati SK, Zaghloul KA. Replay of cortical spiking sequences during human memory retrieval. Science. 2020;367(6482):1131-1134.
Xie W, Bainbridge WA, Inati SK, Baker CI, Zaghloul KA. Memorability of words in arbitrary verbal associations modulates memory retrieval in the anterior temporal lobe. Nat Hum Behav. 2020.
Chapeton JI, Haque R, Wittig JH Jr, Inati SK, Zaghloul KA. Large-Scale Communication in the Human Brain Is Rhythmically Modulated through Alpha Coherence. Curr Biol. 2019;29(17):2801-2811.e5.
Wittig JH Jr, Jang AI, Cocjin JB, Inati SK, Zaghloul KA. Attention improves memory by suppressing spiking-neuron activity in the human anterior temporal lobe. Nat Neurosci. 2018;21(6):808-810.
Vaz AP, Inati SK, Brunel N, Zaghloul KA. Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory. Science. 2019;363(6430):975-978.
Related Scientific Focus Areas
Biomedical Engineering and Biophysics
This page was last updated on April 25th, 2022