First In-Person WALS in Two Years

Anna Huttenlocher Presents Research on Inflammation Resolution and Wound Repair

The Wednesday Afternoon Lecture Series (WALS) has been videocast-only since the start of the COVID-19 pandemic more than two years ago. But on April 6, 2022, NIH welcomed Anna Huttenlocher, from the University of Wisconsin at Madison, as the first in-person WALS presenter since March 4, 2020.

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From the Deputy Director for Intramural Research

My Time as Deputy Director for Intramural Research: What the Future Holds

I’m excited that the next Deputy Director for Intramural Research (DDIR) will bring new energy to NIH’s intramural research program (IRP). In preparation for the transition to new leadership—including a new NIH Director—I have worked closely with NIH scientific and clinical directors to identify four areas of challenges and opportunities that will need to be addressed.

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A Glycobiology Pioneer Uncovers the Secrets of Sugar

Profile: John A. Hanover, Ph.D.

NIDDK Senior Investigator John Hanover has dedicated nearly 40 years to research in glycoscience—the study of glycans, sugar molecules that cloak the surface of all cells and festoon many proteins, lipids, and other molecules. Glycans are inextricably linked to nearly every facet of cellular biology and implicated in conditions from cancer to neurodegenerative diseases and type 2 diabetes.

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Glycobiology Research at NIH

The term “glycobiology” indicates the blending of carbohydrate chemistry and biochemistry, with an understanding of glycans at the cellular and molecular level. Glycans, also known as saccharides and carbohydrates, are sugar molecules that cloak the surface of all cells and festoon many proteins, lipids, and other molecules. Glycans are inextricably linked to nearly every facet of cellular biology and implicated in conditions from cancer to neurodegenerative diseases and type 2 diabetes. NIH has a rich history of glycobiology research. Here are some of the early and current glycobiology investigators. This list is by no means comprehensive.

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Restoring Body and Mind

How Bonnie Hodsdon is Expanding the Reach of Occupational Therapy Research

“Linda” couldn’t write her name, and Bonnie Hodsdon, an NIH occupational therapist, was trying to help her.

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Unfolding the Mystery of Transformer-like Proteins

Lauren Porter’s Research on Fold-switching Proteins

“Fold-switching proteins are like Transformers, like Optimus Prime,” said Stadtman Tenure-Track Investigator Lauren Porter, referring to the hero of the science fiction franchise of shapeshifting humanlike robots. “Sometimes he’s a robot, and sometimes he turns into a car. He uses both of his structures and both of his functions to fight crime.” Similarly, the proteins she studies have multiple stable structures and functions.

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News Brief

Norman Sharpless Steps Down as Director of the National Cancer Institute

Norman E. “Ned” Sharpless announced in early April that he has decided to step down from his position as director of the National Cancer Institute (NCI), a position he has held since 2017.

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Why Climate Change Is a Health Threat

NIH’s New Climate Change and Health Initiative Explores the Risks

The NIH Climate Change and Health Initiative launched a seminar series that invited speakers who are exploring the risks that climate change poses to human health.

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COVID-19 Timeline at NIH (March-April 2022)

COVID-19 Research and Activities at NIH

Highlights of the COVID-19-related activities that were going on at NIH in March and April 2022.

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Research Briefs

Read about NIH scientific advances and discoveries by intramural scientists: complete human genome sequenced; hydration may reduce long-term cardiac risk; peripheral vision attention not driven by tiny eye movements; targeting fat-cell signaling may help treat metabolic disease; newly discovered molecular pathway in two neurodegenerative disorders; and machine learning successfully identifies ALS subtypes.

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Technology Transfer

NCI’s Quest for a Successful HIV Vaccine

Clinical Trial on the Way

Since the beginning of the AIDS epidemic in the 1980s, scientists at the National Cancer Institute (NCI) have made several pivotal discoveries in HIV and AIDS and AIDS-associated cancers. Four decades later, NCI senior investigator Genoveffa Franchini is close to finding a vaccine approach to prevent HIV infection and AIDS.

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The Training Page

From the Fellows Committee

Training Opportunities in Tech Transfer

Many fellows at the NIH share an interest in developing innovative new drug targets, diagnostics, therapies, and technologies and finding ways to move them from the bench to the bedside. But what does it take to bring innovations into the public realm? The answer often lies in technology transfer.

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Colleagues: Recently Tenured

Meet your recently tenured colleagues: Clint T. Allen (NIDCD), John Brognard (NCI-CCR), Jonathan Hofmann (NCI-DCEG), Yuichi Machida (NCI-CCR), and Quan Yuan (NINDS, pictured)

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From the Annals of NIH History

Biologics Regulation and Research

The People and Work of Buildings 29 and 29A

Two soon-to-be demolished buildings—the Biologics Standards Laboratory Building (Building 29) and the Biologics Standards Laboratory Annex (Building 29A)—are nationally significant to the history of medicine and public health. They will live on in a new website hosted by the Office of NIH History and Stetten Museum.

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The SIG Beat

News From and About the Scientific Interest Groups

Two new SIGS: The Consciousness Research Interest Group will provide a platform to discuss, discover, collaborate, and stimulate the research of the science of consciousness; the Metastasis Scientific Interest Group will support metastasis-related research at the NIH.

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Announcements

News about May 24 PBS documentary that features NIH founder; events, deadlines, lectures, and more.

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