Pioneering Gene Therapy for Radiation-Induced Dry Mouth

Ongoing Clinical Trial Explores Saliva-restoring Gene Transfer

For most individuals who survive head and neck cancers, the relief of successful treatment can be tempered by a troubling side effect of some cancer therapies: chronic dry mouth. Treatments can help, including saliva substitutes, salivary stimulants, and ice chips that moisten the mouth. But there’s no cure for radiation-induced dry mouth. NIDCR investigators have developed the first-ever salivary-gland gene therapy tried in humans.

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News Briefs

Brian Berridge Tapped to Manage National Toxicology Program

The National Toxicology Program (NTP), a federal interagency program housed in the National Institute of Environmental Health Sciences (NIEHS) intramural research program, welcomed Brian Berridgeformerly of GlaxoSmithKline, as its new associate director. 

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News You Can Use

The Genomic Ascertainment Cohort is Open for Business

The past decade has seen an explosion in the availability of genome-scale data—including chip genotypes, exome sequences, and even full-genome sequences—from hundreds of thousands of individuals. But even with all these data, it can be challenging for scientists to figure out the exact roles that particular genetic variants play in the development of diseases. Often, the problem is not the research itself, but the difficulty of finding enough people with the variant of interest.

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Colleagues: Recently Tenured

Meet your recently tenured colleagues: Paul William Doetsch (NIEHS, pictured), Iain Fraser (NIAID), Claudia Palena (NCI-CCR), Mark Purdue (NCI-DCEG), and Wai T. Wong (NEI)

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Back Page: Catalytic Research

NICHD: First 3-D Structure of DHHC Enzymes

The first three-dimensional structure of DHHC proteins—proteins that contain a 50-amino-acid chain called the DCCT domain, act as enzymes, and are involved in many cellular processes, including cancer—explains how they function and may offer a blueprint for designing therapeutic drugs.

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Behavioral and Social Sciences Research Festival 2017

Charting New Paths

“These days, we once again see behavioral science at the forefront of health research,” said NIH Principal Deputy Director Lawrence Tabak during the opening remarks of the NIH Behavioral and Social Sciences Research Festival.

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Research Briefs

Read about recent intramural research advances: how to keep a cancer drug from causing hearing loss; chemical in cactus-like plant may control surgical pain; skin microbes promote tissue healing; eye could provide window to the brain after stroke; and more.

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The Training Page

Career Advice from NIH Scientist Serena Dudek

NIEHS scientist Serena Dudek offered career advice to attendees at the Society for Neuroscience conference, held in Washington, D.C., recently.

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The SIG Beat: New SIGs

NEWS FROM AND ABOUT THE SCIENTIFIC INTEREST GROUPS

NEW SIG: Genetic Counseling Scientific Interest Group

CREDIT: NHGRI

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Announcements

News about awards, events, deadlines, courses, and more.

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