Higher Brain Glucose Levels May Mean More-Severe Alzheimer Disease

Connections between glucose metabolism, Alzheimer’s pathology, symptoms

illustration of cross section of brain

CREDIT: NIA

Scientists in the National Institute on Aging found potential connections between problems with how the brain processes glucose and Alzheimer disease: glucose processed normally (red); glucose processed poorly (blue) so there’s excess in some areas of the brain.

For the first time, scientists have found a connection between abnormalities in how the brain breaks down glucose and the severity of the signature amyloid plaques and tangles in the brain, as well as the onset of eventual outward symptoms, of Alzheimer disease. The study was led by researchers at the National Institute on Aging.

Read more about this and other NIH advances in “Research Briefs.”