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I am Intramural Blog

bone marrow

Bone Marrow Cells Reveal Secret Weapon to Battle Bacteria

Research Could Lead to Cell-Based Therapies for Infections and Autoimmune Reactions

Tuesday, May 7, 2024

bacterial colonies growing in a petri dish

One thing many scientists love about their job is that the topic they study can still surprise them even after decades of research. IRP senior investigator Eva Mezey, M.D., Ph.D., for instance, has spent the last 20 years investigating a particular set of cells in the bone marrow, yet until now she had never uncovered one of their most intriguing tricks. In a recent study, her IRP team and its collaborators discovered that those cells make a substance that can fight infections and tame hyper-active immune responses.

Treatment Corrects Consequences of Accelerated Cellular Aging

Mouse Study Demonstrates Promise of New Therapy for Rare Genetic Conditions

Tuesday, June 6, 2023

time warp

If you ask a scientist how old you are, you may be surprised to get a different answer depending on who you’re talking to. That’s because age can be measured both ‘chronologically’ — in terms of time — and at a cellular level. Indeed, certain genetic mutations cause cells to age faster, leading to a host of health problems. Fortunately, a recent IRP study performed in mice suggests that boosting levels of a specific molecule could help alleviate some of those patients’ symptoms.

Non-Toxic Drug Could Increase Availability of Organ Transplants

Treatment Regimen Allows Genetically Mismatched Skin Grafts in Mice

Tuesday, June 25, 2019

surgeons performing an organ transplant

Thousands of patients who need an organ transplant die each year before a donor can be found. A new IRP study has identified a safer way to prevent a transplant recipient’s body from attacking a genetically dissimilar donor organ, which could dramatically expand the pool of potential organ donors.

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