Skip to main content
NIH Intramural Research Program, Our Research Changes Lives

Navigation controls

  • Search
  • Menu

Social follow links

  • Podcast
  • Instagram
  • Twitter
  • YouTube
  • LinkedIn

Main navigation

  • About Us
    • What Is the IRP?
    • History
    • Honors
      • Nobel Prize
      • Lasker Award
      • Breakthrough Prize
      • Shaw Prize
      • Presidential Early Career Award for Scientists and Engineers (PECASE)
      • Presidential Medal of Freedom
      • National Medal of Science
      • Searle Scholars
      • The National Academy of Sciences
      • The National Academy of Medicine
      • The National Academy of Engineering
      • The American Academy of Arts and Sciences
      • National Medal of Technology & Innovation
      • Samuel J. Heyman Service to America Medals
      • Crafoord Prize
      • Fellows of the Royal Society
      • Canada Gairdner Awards
    • Organization & Leadership
    • Our Programs
      • NCI
      • NEI
      • NHGRI
      • NHLBI
      • NIA
      • NIAAA
      • NIAID
      • NIAMS
      • NIBIB
      • NICHD
      • NIDA
      • NIDCD
      • NIDCR
      • NIDDK
      • NIEHS
      • NIMH
      • NIMHD
      • NINDS
      • NINR
      • NLM
      • CC
      • NCATS
      • NCCIH
    • Research Campus Locations
    • Contact Information
  • Our Research
    • Scientific Focus Areas
      • Biomedical Engineering & Biophysics
      • Cancer Biology
      • Cell Biology
      • Chemical Biology
      • Chromosome Biology
      • Clinical Research
      • Computational Biology
      • Developmental Biology
      • Epidemiology
      • Genetics & Genomics
      • Health Disparities
      • Immunology
      • Microbiology & Infectious Diseases
      • Molecular Biology & Biochemistry
      • Molecular Pharmacology
      • Neuroscience
      • RNA Biology
      • Social & Behavioral Sciences
      • Stem Cell Biology
      • Structural Biology
      • Systems Biology
      • Virology
    • Principal Investigators
      • View by Investigator Name
      • View by Scientific Focus Area
    • Accomplishments
      • View All Accomplishments by Date
      • View All Health Topics
      • The Body
      • Health & Wellness
      • Conditions & Diseases
      • Procedures
    • Accelerating Science
      • Investing in Cutting-Edge Animal Models
      • Creating Cell-Based Therapies
      • Advancing Computational and Structural Biology
      • Combating Drug Resistance
      • Developing Novel Imaging Techniques
      • Charting the Pathways of Inflammation
      • Zooming in on the Microbiome
      • Uncovering New Opportunities for Natural Products
      • Stimulating Neuroscience Research
      • Pursuing Precision Medicine
      • Unlocking the Potential of RNA Biology and Therapeutics
      • Producing Novel Vaccines
    • Research in Action
      • View All Stories
      • Battling Blood-Sucking Bugs
      • Unexpected Leads to Curb Addiction
      • Shaping Therapies for Sickle Cell Disease
      • The Mind’s Map Maker
    • Trans-IRP Research Resources
      • Supercomputing
    • IRP Review Process
    • Commercializing Inventions
  • NIH Clinical Center
    • Clinical Center Facilities
    • Clinical Faculty
    • Advancing Translational Science
    • Clinical Trials
      • Get Involved with Clinical Research
      • Physician Resources
  • News & Events
    • In the News
    • I am Intramural Blog
    • Speaking of Science Podcast
    • SciBites Video Shorts
    • The NIH Catalyst Newsletter
    • Events
  • Careers
    • Faculty-Level Scientific Careers
    • Trans-NIH Scientific Recruitments
      • Stadtman Tenure-Track Investigators
        • Science, the Stadtman Way
      • Lasker Clinical Research Scholars
      • Independent Research Scholar
    • Scientific & Clinical Careers
    • Administrative Careers
  • Research Training
    • Program Information
    • Training Opportunities
    • NIH Work/Life Resources
The NIH Catalyst: A Publication About NIH Intramural Research

National Institutes of Health • Office of the Director | Volume 21 Issue 6 • November–December 2013

Departments

From the Deputy Director for Intramural Research

Recovering from the Shutdown: The Toll on Biomedical Research

BY MICHAEL GOTTESMAN, DDIR

NIH is the largest purely biomedical research facility in the world, with about 2,500 individual research projects and close to 1,500 clinical protocols. But during the 16-day federal government shutdown in October, the NIH Intramural Program (IRP) was profoundly affected. Its loss of progress is a big deal.

Read more

The SIG Beat

Proteostasis

BY JENNIFER SARGENT, NIAMS

Proteostasis, a seemingly straightforward fusion of the words “protein” and “homeostasis,” is actually a fertile and multifaceted concept. Ask any 10 scientists to define it, and you’re bound to get 10 different answers, and those opinions may change from year to year. Proteostasis encompasses the study of all areas of protein health and fitness that contribute to maintaining cellular integrity and function. Derailed proteostasis leads to protein misfolding and aggregation that is known or suggested to be implicated in many devastating human disorders.

Read more

The Training Page

FROM THE OFFICE OF INTRAMURAL TRAINING AND EDUCATION

Training to Work Well with Others

BY LORI CONLAN AND SHARON MILGRAM, OD

Nearly two-thirds of scientists surveyed reported that interpersonal conflict had hampered progress on a scientific project one to five times in their career. OITE has developed a program to train scientists to work well with others and manage conflictsso they can accomplish more science.

Read more

New Methods

New Microscopes That Reveal Cellular Processes in 3-D

May Help Scientists Observe How Viruses Attack

BY JESSICA MEADE, NIBIB

NIH researchers have developed two new high-resolution microscopes, both the first of their kind. The first—an instant linear structured illumination microscope (iSIM)—captures high-resolution images of small, fast-moving cellular structures in real time. The second—a dual-view inverted selective plane illumination microscope (diSPIM)—displays large cell samples in three dimensions (3-D) while decreasing the amount of harmful light that cells are exposed to during imaging.

Read more

News You Can Use

NIH Library: Custom Information Solutions Service

BY MASHANA DAVIS, NIH LIBRARY

The NIH Library recently introduced a new service, “Custom Information Solutions,” that can customize services and resources to address the specific needs of a group. Customized services include digitizing NIH-created print materials; building databases to support research projects; developing portfolio-analysis reports; and creating customized Web search tools.

Read more

Research Briefs

Recent intramural discoveries and developments include: enteroviruses need cholesterol to replicate; new drugs could slow progress of fatal disorder; candidate vaccine against respiratory syncytial virus; tanning gene linked to testicular cancer; and molecular structure of amyloid plaques.

Read more

Announcements

Highlights of NIH lectures, events, activities, and awards including winners of the 2013 Nobel Prize in Chemistry on November 18 and 20; Marston Linehan giving the Astute Clinician Lecture on November 20; the Chen Lecture on Innovation and Technology Transfer will be on November 22; three NIHers are new IOM members; and more.

Read more

  • Issue Overview
  • Features
    • The Human Microbiome Project
    • The Shutdown
    • Sammies Honored at the White House
    • Viewing the Human Retina Through the Eyes of a Ground Squirrel
    • HIV and AIDS: Much Accomplished, Much to Do
    • From Zoo to Bedside
  • Departments
    • From the Deputy Director for Intramural Research
    • The SIG Beat
    • The Training Page
    • New Methods
    • News You Can Use
    • Research Briefs
    • Announcements
  • Issue Contents
  • Download this issue as a PDF

Catalyst menu

  • Current Issue
  • Previous Issues
  • About The NIH Catalyst
  • Contact The NIH Catalyst
  • Share Your Story
  • NIH Abbreviations

Subscribe Today!

Subscribe to The NIH Catalyst Newsletter and receive email updates.

Subscribe

Get IRP Updates

Subscribe

  • Email
  • Print
  • Share Twitter Facebook LinkedIn

Main navigation

  • About Us
    • What Is the IRP?
    • History
    • Honors
    • Organization & Leadership
    • Our Programs
    • Research Campus Locations
    • Contact Information
  • Our Research
    • Scientific Focus Areas
    • Principal Investigators
    • Accomplishments
    • Accelerating Science
    • Research in Action
    • Trans-IRP Research Resources
    • IRP Review Process
    • Commercializing Inventions
  • NIH Clinical Center
    • Clinical Center Facilities
    • Clinical Faculty
    • Advancing Translational Science
    • Clinical Trials
  • News & Events
    • In the News
    • I am Intramural Blog
    • Speaking of Science Podcast
    • SciBites Video Shorts
    • The NIH Catalyst Newsletter
    • Events
  • Careers
    • Faculty-Level Scientific Careers
    • Trans-NIH Scientific Recruitments
    • Scientific & Clinical Careers
    • Administrative Careers
  • Research Training
    • Program Information
    • Training Opportunities
    • NIH Work/Life Resources
  • Department of Health and Human Services
  • National Institutes of Health
  • USA.gov

Footer

  • Home
  • Contact Us
  • IRP Brand Materials
  • HHS Vulnerability Disclosure
  • Web Policies & Notices
  • Site Map
  • Search