Tom Misteli, Ph.D., is an internationally renowned pioneer in the field of genome cell biology. He serves as Director of NIH's National Cancer Institute (NCI), as well as chief of NCI's Laboratory of Receptor Biology and Gene Expression. He trained at the University of London in the UK and at the Cold Spring Harbor Laboratory in New York, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory at NIH aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal, and the Herman Beerman Award. He also acts as an advisor for several national and international agencies, and serves on numerous editorial boards.