Tom Misteli, Ph.D.

Cell Biology of Genomes

My laboratory explores the cell biology of genomes.

Defects in genome organization and nuclear architecture are responsible for numerous chronic human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. Genome alterations are often triggered by environmental factors including radiation and nutritional toxins.

We use molecular techniques in conjunction with live-cell microscopy, and high-throughput screening to understand how genomes are organized in intact cells and how the spatial organization of genomes contributes to their function. Using synthetic biology approaches, we seek to control and correct genome organization to counteract defects that accumulate during chronic disease and aging.

Our studies have provided insights into fundamental biological mechanisms and have established the foundation for novel diagnostic and clinical applications in cancer and premature aging.

Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for chronic diseases such as cancer as well as aging. He has received numerous awards for his work, acts as an advisor for national and international agencies and serves on major editorial boards, including Cell, Science and PLOS Bioogy. He has received numerous awards including the EB Wilson Award, the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.