apoptosis

Cellular Self-Destruct Tied to Type 2 Diabetes

Study Suggests New Treatment Strategy for Increasingly Common Disease

a cell undergoing apoptosis

In the classic sci-fi film Alien, the protagonist attempts to destroy the titular monster by triggering the self-destruct mechanism on her spaceship. Our cells also sometimes need to destroy themselves in order to circumvent threats like cancer, but uncontrolled cell death can lead to disease. New IRP research suggests that preventing certain cells in the pancreas from tripping their self-destruct switch could help relieve the symptoms of type 2 diabetes.

From Mitochondria to Behavior

Mitochondria are dynamic cellular organelles involved in ATP synthesis and in apoptotic mechanisms (programmed cell death). However, in addition to these classically known functions, recent studies at the NIH have deciphered another intriguing role for mitochondria in the development and plasticity of neurons.

Mitochondria