An Interview with Hynda Kleinman
The Matrigel-Maker’s Story
BY LAURA STEPHENSON CARTER
Hynda Kleinman, who worked at NIH from 1975 to 2006, revolutionized cell-culture research when she co-invented Matrigel at NIH in the 1980s. Until then, scientists mainly grew cells in a flat layer in plastic culture dishes, but Matrigel made it possible to grow cells in a three-dimensional matrix that closely resembles the natural environments in which most mammalian cells grow. In a recent interview with the NIH Catalyst, Kleinman shared some of the secrets of her success, including how she came to be listed in the credits of a classic movie.
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