Major Shared and Multi-Institute Research Resources

The NIH Intramural Research Program has a long history of interactions and shared resources among its investigators. These include core facilities that support crucial research activities, such as a sequencing center, a magnetic resonance imaging facility, a mass spectroscopy service, and a protein expression service. The most prominent example is the NIH Clinical Center, the nation’s largest hospital devoted entirely to clinical research, providing comprehensive services and facilities in support of clinical research sponsored by the institutes and centers. In addition, the NIH Office of Intramural Training and Education organizes and sponsors a variety of training and career-development activities for the entire intramural community. Various mechanisms are used to support these resources, including contributions from participating NIH institutes and centers such as the management funds, user fees, and program support from the Office of Intramural Research.

Resources Available to All Institutes and Centers (ICS)
Research Resource Location Participants Governance Contact Research Services Review
Center for Information Technology (CIT) Building 12 complex All ICs CIT Benes Trus, acting scientific director Image processing, bioinformatics, computational methods and algorithms, computer engineering, bioscience, molecular modeling, mathematical and statistical computing, supercomputing, software development; http://www.cit.nih.gov/science.html Shared Resources Subcommittee, ICs
Division of Medical Arts Building 10, B2 level All ICs Office of Research Services Lem Canady, chief Medical illustration, photomicroscopy, photomacroscopy, scientific posters; http://medarts.nih.gov/  
Division of Library Services Building 10 All ICs Office of Research Services Terrie Wheeler, acting director Full-service library, including electronic journals, electronic document desktop delivery and translations; http://nihlibrary.nih.gov/ Users Committee, ICs
Division of Scientific Equipment and Instrumentation Services Building 13 All ICs Office of Research Services Johnny Robbins, chief Maintain scientific equipment and computers; design and fabricate custom instruments; lease and sell scientific and medical equipment; http://dseis.od.nih.gov/ (NIH Intranet only) Shared Resources Subcommittee, ICs
Division of Veterinary Resources Building 14–28 complex; Bethesda; Poolesville All ICs Office of Research Services Charmaine Foltz, director Veterinary services (surgery, radiology, pharmacy, nutrition, animal behavior and enrichment); animal husbandry, procurement, quarantine, and health surveillance; diagnostics (pathology, bacteriology, parasitology, serology, mouse phenotyping) Shared Resources Subcommittee, ICs
Multi-Institute Shared Services
Research Resource Location Participants Governance Contact Research Services Review
Biomedical Engineering and Physical Science Building 13 Available to all ICs Steering Committee Henry Eden, Acting Chief Micro analytical immunochemistry; microfabrication and microfluidics; transmission and scanning electron microscopy; scanning probe microscopy; quantitative methods for molecular interactions; clinical/basic infrared imaging; http://www.nibib.nih.gov/Research/Intramural/SharedResource Shared Resources Subcommittee, ICs, Steering Committee
Biotechnology Core Laboratory Building 6, Room B1–33 Lead IC: NIDDK; major client: NICHD   Joseph Shiloach, director Production and purification of biological material, especially scale-up protein production and purification; http://www2.niddk.nih.gov/NIDDKLabs/AllLabs/CoreFacilities/BiotechnologyCoreLaboratory.htm Board of Scientific Counselors, ICs
Bone Marrow Stromal Cell Transplantation Center Building 10 Steering Committee: CC, NIDCR, NIAID, NIAMS, NIBIB, NCI, NINDS Oversight Committee: NINDS, NIAID, NCI, NIDCR Harvey Klein (CC), Pamela Robey (NIDCR) Production facility for bone marrow stromal (mesenchymal) stem cells for clinical research  
Center for Human Immunology (CHI) CC Available to all ICs Steering Commitee Neal Young, director Translational research in immunology, autoimmunity, and inflammation; http://www1.od.nih.gov/oir/sourcebook/ir-communictns/chi.htm IC Director Steering Committee
Center for Inherited Disease Research Bayview Research Campus, Baltimore Lead contracting IC: NHGR; all ICs may participate Review: CIDR Board of Governors David Valle, Johns Hopkins University Genotyping, DNA banking, statistical genetics consultation, mouse genotyping; http://www.cidr.jhmi.edu/ CIDR Access Committee (Camilia Day, NHGRI)
NIH Clinical Center Building 10 complex Available to all ICs Clinical Center Governing Board John Gallin, director Research hospital that accommodates 234 inpatients, 80 day-hospital stations, and outpatients and provides comprehensive services and facilities in support of clinical research sponsored by the ICs; http://www.cc.nih.gov/ Joint Comm.; Board of Scientific Counselors; NIH Advisory Board for Clinical Research
Imaging Probe Development Center (IPDC) 9800 Medical Center Dr., Building B, Room 3042, Rockville, Md. Lead IC: NHLBI Roadmap Initiative Gary Griffiths, director Production of new imaging probes for the intramural NIH research community; http://www.nhlbi.nih.gov/research/intramural/researchers/programs/imaging-probe-development-center  
Mouse Imaging Facility Building 10, In Vivo NMR Center Lead ICs: NINDS, NHLBI; Participants, all ICs but NIEHS are paid charter members Steering Committee Alan Koretsky, director Mouse radiologic imaging; 7T rodent MRI, microCT, high-frequency ultrasound, laser Doppler; http://intranet.nmrf.nih.gov/ (NIH Intranet only) Shared Resources Subcommittee, ICs, Steering Committee
NIH Chemical Genomics Center (NCGC) 9500 Medical Center Drive, Rockville, Md. Lead IC: NHGRI   Chris Austin, director Ultrahigh-throughput screening center of the Molecular Libraries Screening Center Network that generates chemical probes for understanding molecular and cellular functions and serve as starting points for drug development, particularly for rare and orphan diseases; http://www.ncgc.nih.gov/  
NIH Intramural Sequencing Center (NISC) 5625 Fishers Lane, 5th Floor, Rockville, Md. Participants: NHGRI, NCBI, NIDCD, NIAAA, NIDA, NHLBI, NIDDK, NICHD, NEI, NIAMS, NINDS, NIDCR, NIEHS, NIMH Users Committee Eric Green, director Production-scale DNA sequencing, assimilation and analysis of sequence data, instrumentation, sequence analysis software; http://www.nisc.nih.gov/  
NIH Magnetic Resonance Imaging Facility Building 10, In Vivo NMR Center Lead IC: NINDS; all ICs except NIEHS Steering Committee Alan Koretsky, director Human and animal MRI; other IC MRI instruments available; http://intranet.nmrf.nih.gov/ (NIH Intranet only) Shared Resources Subcommittee, ICs, Steering Committee
PET Imaging Building 10, Room 1C401 Lead IC: CC Steering Committee Peter Herscovitch, director State-of-the-art facility with three medical cyclotrons and ten hot cells to produce positron-labeled radiopharmaceuticals, as well as four PET scanners; Good Manufacturing Practice facility with additional hot cells under construction; http://www.cc.nih.gov/pet/index.html  
Protein Expression Lab Building 6B, Room 1B130 Lead IC: NIAMS; Participants: NHGRI, NCBI, NIDCD, NIAAA, NIDA, NHLBI, NIDDK, NICHD, NEI, NIAMS, NINDS, NIDCR, NIEHS, NIMH; any IC may request service   Paul Wingfield, chief Expression, purification, and structural characterization of HIV and HIV-related proteins via a variety of techniques; protein EXE software; supply HIV-1 protease; http://www.niams.nih.gov/Research/Ongoing_Research/Branch_Lab/Protein_Expression/default.asp Intramural AIDS Targeted Antiviral Program, ICs
Stem Cell Unit Building 35, Room 3A201 Lead IC: NINDS Steering Committee Pam Robey, acting director Facility uses a standardized paradigm to conduct side-by-side comparisons of the available cell lines on the NIH Human Embryonic Stem Cell Registry and shares the results with the scientific community; http://stemcells.nih.gov/research/nihresearch/scunit  
Synchrotrons:            
1. Advanced photon source Argonne National Lab DOE   http://www.aps.anl.gov/ High-brilliance X-ray beams  
Core Facilities on a Space-Available Basis
Research Resource Location Participants Governance Contact Research Services Review
Facility for Biotechnology Resources (FBR): CBER Biotechnology Core Facility Building 29, Rooms 200-208 Participants: NHGRI, NIDCD, NHLBI, NIDDK, NICHD, NEI, NIAMS, NIDCR, CC, NCI – fee-for-service FDA’s Center for Biologics Evaluation and Research (CBER) Nga Y. Nguyen, CBER FDA Services include: amino acid sequence analysis; DNA sequencing; oligonucleotide synthesis; peptide synthesis; mass spectrometry services; analytical and preparative HPLC services; capillary electrophoresis; http://128.231.52.66/default.htm (NIH Intranet only) CBER
Mass Spectroscopy Building 8A, Room B2A19–21; Building 10 Lead ICs: NIDDK, NHLBI, NIMH, NIAID, NINDS Advisory Group   QTOF–LCMS; high-resolution magnetic sector; MALDI, LC-ion trap Board of Scientific Counselors, ICs
Structural Biology NMR Buildings 5, 6A, and 50 All ICs Steering Committee Lead ICs: Ad Bax (NIDDK), Nico Tjandra (NHLBI) Study of macromolecular structure and interaction; 500-, 600- and 800-MHz cryoprobe NMR spectrometers; 900-MHz spectrometer ICs