Research advances from the National Institutes of Health (NIH) Intramural Research Program (IRP) often make headlines. Read the news releases that describe our most recent findings:
Whether you’re shedding pounds with the help of effective new medicines, slimming down after weight loss surgery or cutting calories and adding exercise, there will come a day when the numbers on the scale stop going down, and you hit the dreaded weight loss plateau.
In a recent study, Kevin Hall, a researcher at the National Institutes of Health who specializes in measuring metabolism and weight change, looked at when weight loss typically stops depending on the method people were using todrop pounds. He broke down the plateau into mathematical models using data from high-quality clinical trials of different ways to lose weight to understand why people stop losing when they do. The study published Monday in the journal Obesity.
Sooner than almost anyone expected, a new, genome-based technology for demystifying undiagnosed illnesses — particularly rare childhood diseases — is moving from research laboratories into general medical practice. Now, two leading scientists have sketched out what doctors need to know in order to use the new technology effectively.
Public website promotes health and science applications of 3D printing
The National Institutes of Health has launched the NIH 3D Print Exchange, a public website that enables users to share, download and edit 3D print files related to health and science. These files can be used, for example, to print custom laboratory equipment and models of bacteria and human anatomy.
Study may advance understanding of how brain cell tubes are modified under normal and disease conditions
In a new study, scientists at the National Institutes of Health took a molecular-level journey into microtubules, the hollow cylinders inside brain cells that act as skeletons and internal highways. They watched how a protein called tubulin acetyltransferase (TAT) labels the inside of microtubules. The results, published in Cell, answer long-standing questions about how TAT tagging works and offer clues as to why it is important for brain health.
NIH study reveals way to improve bone health for young women with POI
Researchers have found that hormone replacement therapy in young women with primary ovarian insufficiency (POI) led to increases in their bone mineral density, restoring levels to normal. The study was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health.
New report outlines initiative goals, budget, and timeline
A federal report calls for $4.5 billion in funding for brain research over the next 12 years. The long-term scientific vision of the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative was presented today to National Institutes of Health Director Francis S. Collins, M.D., Ph.D., by his Advisory Committee to the Director (ACD). Dr. Collins accepted the recommendations, calling the report bold and game changing.
Stunning scientific images of blood, brain, bacteria, viruses and more, enlarged by as much as 50,000 times, are on display in an exhibit called “Life: Magnified,” on view through November 2014 at Washington Dulles International Airport’s Gateway Gallery. The gallery, en route to Concourse C, is in a two-level walkway through which about 2.5 million passengers pass each year.
Comprehensive review published in the New England Journal of Medicine also discusses why risks are greatest for teen users
The current state of science on the adverse health effects of marijuana use links the drug to several significant adverse effects including addiction, a review reports. The article, published today in the New England Journal of Medicine, is authored by scientists from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.
NIH preclinical study suggests higher risk of death is associated with warmer brain temperature
A moderate dose of MDMA, commonly known as Ecstasy or Molly, that is typically nonfatal in cool, quiet environments can be lethal in rats exposed to conditions that mimic the hot, crowded, social settings where the drug is often used by people, a study finds. Scientists have identified the therapeutically-relevant cooling mechanism to enable effective interventions when faced with MDMA-induced hyperthermia. The study, publishing tomorrow in the Journal of Neuroscience, was conducted by researchers at the National Institute on Drug Abuse’s Intramural Research Program (NIDA IRP). NIDA is a part of the National Institutes of Health.
Finding offers insight into how sensory cells find their position
Researchers at the National Institutes of Health have uncovered a molecule in an animal model that acts as a key player in establishing the organization of the auditory system. The molecule, a protein known as Bmp7, is produced during embryonic development and acts to help sensory cells find their ultimate position on the tonotopic map, which is the fundamental principle of organization in the auditory system. The tonotopic map groups sensory cells by the sound frequencies that stimulate them. The study is the first to identify one of the molecular mechanisms that determines position.
Couples with highest cholesterol took longest to achieve pregnancy
High cholesterol levels may impair fertility in couples trying to achieve a pregnancy, according to a study by researchers at the National Institutes of Health, the University at Buffalo (New York), and Emory University in Atlanta.
